Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease

Technologic advances have provided the means to deliver tumoricidal doses of radiation therapy (RT) to patients with unresectable hepatocellular carcinoma (HCC) while avoiding critical normal tissues, providing the opportunity to use RT for curative intent treatment of HCC. For the current report, the expanded role of external beam RT in the setting of HCC from palliation to cure was reviewed. A systematic literature search was undertaken using the MEDLINE data base and secondary references to identify peer-reviewed, English-language articles that re- control response rates ranged from 40% to 90%, and the median survival ranges from 10 months to 25 months. For patients with HCC who had portal vein thrombus, the median survival after RT to treat the thrombus and/or the hepatic tumor with or without TACE ranged from 5.3 months to 9.7 months. Although outcomes after high-dose conformal RT for liver-confined HCC were excellent, the potential survival benefit of RT should be tested in randomized controlled trials that require international collaboration.

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“…36 The tolerance of the liver to radiation was reduced in patients who had hepatitis B compared with patients who had hepatitis C. 36 …”

Section: Liver Tolerance To Radiationmentioning

confidence: 99%

“…Reactivation of viral hepatitis and precipitation of underlying liver disease also can occur after RT for HCC. 36 In addition to liver toxicities, normal tissues adjacent to the liver, including the stomach, duodenum, and kidneys, are at risk of injury from RT if dose cannot be spared from these organs.…”

mentioning

confidence: 99%

Radiation therapy for hepatocellular carcinoma

Hawkins

Dawson

2006

Cancer

221

171

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“…However, RILD is still an important issue in treating HCC patients by radiotherapy. In addition to dose-related factors affecting RILD, such as higher total dose or larger fraction size, Cheng et al 31 reported that patients with CP-B or hepatitis B virus (HBV) are also at a significant risk of developing RILD.…”

Section: Toxicitymentioning

confidence: 99%

“…Patients with HBV have a significantly greater susceptibility to RILD after radiotherapy than patients with HCV. 31 Thus, HBV or HCV infection and liver cirrhosis status must be considered when contemplating SBRT for HCC.…”

mentioning

confidence: 99%

Stereotactic body radiation therapy in hepatocellular carcinoma: Optimal treatment strategies based on liver segmentation and functional hepatic reserve

Wang

Chung

Hsu

et al. 2015

Reports of Practical Oncology & Radiotherapy

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“…16 These projections have been validated in other reports. 17,18 The liver is one of the largest organs of the body; its triangular shape renders different adjacent organs such as the duodenum, colon, small bowels and kidney vulnerable depending on the liver segment involved leading to side-effects like nausea, vomiting, segmental colitis, renal damage and even radiation induced portal vein thrombosis.…”

Section: Radiation Tolerance Of Livermentioning

confidence: 99%

Role of External Beam Radiation Therapy in Management of Hepatocellular Carcinoma

Sharma

2014

Journal of Clinical and Experimental Hepatology

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Diagnosis at advanced disease stage and early vascular invasion are the bane of majority of patients with hepatocellular carcinoma (HCC) in India. The currently standardized curative and palliative treatment modalities [surgery, ablative techniques, trans-catheter chemotherapy, systemic chemotherapy] are suboptimal for a significant proportion of disease stages. Interest in radiotherapy for hepatocellular carcinoma has seen a resurgence with revolutionary improvements in targeting radiation doses safely. Encouraging results have been reported with a host of radiation techniques from conformal radiotherapy, stereotactic whole body radiation therapy to charged particle based therapies. The dissemination of this knowledge has been slow across other specialties involved in care of patients with HCC. However the increasing availability of radiotherapy services predicts a hopeful future for wider evaluation of radiotherapy in HCC. ( J CLIN EXP HEPATOL 2014;4:S122-S125)

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Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease

Cited by 176 publications

References 25 publications

Radiation therapy for hepatocellular carcinoma

Radiation therapy for hepatocellular carcinoma

Stereotactic body radiation therapy in hepatocellular carcinoma: Optimal treatment strategies based on liver segmentation and functional hepatic reserve

Role of External Beam Radiation Therapy in Management of Hepatocellular Carcinoma

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