Biologic Therapies in HIV/AIDS Patients with Inflammatory Diseases: A Systematic Review of the Literature

Biological therapies have revolutionized medical treatment by targeting the key mediators or receptors involved in inflammatory responses, thereby effectively suppressing inflammation and achieving beneficial outcomes. They are more advanced than conventional therapies using corticosteroids and immunosuppressants, offering effective solutions for autoimmune diseases, cancer, transplant rejection, and various infectious diseases, including coronavirus disease 2019. Although they exert low immunosuppressive effects, biological therapies can reactivate specific biological targets associated with infections. This review summarizes the currently available biological therapies and discusses their immunosuppressive mechanisms and clinical applications, highlighting the variations in the types and frequencies of infection recurrence induced by different biological agents. Additionally, this review describes the risk factors associated with various biological agents, thus aiding clinicians in selecting the most appropriate biological therapy.

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Successful Biological Treatment of a Patient With Psoriasis and HIV

Ortegon Blanco,

Alonzo Canul

2024

Cureus

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The use of biological agents for the management of chronic dermatological pathologies such as psoriasis is becoming more common every day. Until now, antibodies against tumor necrosis factors (TNF-α) inhibitors, interleukin IL-17 inhibitors, IL-12/23 inhibitors, and IL-23 inhibitors have been marketed as biological therapies for psoriasis, showing excellent results with a minimal number of adverse events. Initially, the first biological treatments were associated primarily with opportunistic infections. Later, specific adverse events were described depending on the biological agent used: TNF-α inhibitors were linked to tuberculosis, while anti-IL-17 agents were associated with candidiasis and worsening of inflammatory bowel disease (IBD). However, such therapies warrant a cautious screening protocol to detect pre-existing infections, mainly tuberculosis and chronic viral infections such as hepatitis. Human immunodeficiency virus (HIV) is only screened in case of suspicion and in some institutional protocols. We present the clinical case of a person living with HIV under optimal virological control, in which the use of biological therapy was imperative to control psoriasis and he also presented with great severity. Until now there is no official statement on the use or not of biologicals in this particular population.

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Biologic Therapies in HIV/AIDS Patients with Inflammatory Diseases: A Systematic Review of the Literature

Cited by 3 publications

References 113 publications

HIV-related exclusion criteria in atopic dermatitis and prurigo nodularis clinical trials

HIV-related exclusion criteria in atopic dermatitis and prurigo nodularis clinical trials

Applications of Biological Therapy for Latent Infections: Benefits and Risks

Successful Biological Treatment of a Patient With Psoriasis and HIV

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