2023
DOI: 10.24875/jimids.m22000019
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Biologic therapy and paradoxical reactions

Abstract: Paradoxical reactions are defined as adverse effects that manifest as a de novo appearance or the exacerbation of a condition that commonly responds to a certain class of drug. A well-known example of paradoxical reaction is the debut of psoriatic eruptions when patients undergo anti-tumor necrosis factor-alpha (TNF-α) therapy for inflammatory bowel disease. Initially, they were described as isolated events among patients who received the aforementioned drug agents for inflammatory rheumatic diseases. Later, p… Show more

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