Biological Actions of CCK in the Gastrointestinal Tract

Solomon, Travis E.

doi:10.1007/978-3-642-76362-5_4

Cholecystokinin Antagonists in Gastroenterology 1991

DOI: 10.1007/978-3-642-76362-5_4

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Biological Actions of CCK in the Gastrointestinal Tract

Travis E. Solomon

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Cited by 2 publications

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Effect of Cholecystokinin on Gastric Motility in Humansa

Beglinger

1994

Annals of the New York Academy of Sciences

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Gastric emptying after food ingestion is regulated by neural and hormonal factors. However, the relative contributions of each pathway is not yet clearly defined. The classic gut hormone CCK seems to be involved in the regulation of gastric emptying in humans. Experimental evidence is best for gastric emptying of liquid meals that release CCK from the duodenum: (1) CCK infused at postprandial plasma concentrations inhibits gastric emptying of a liquid and a semisolid meal. (2) Administration of the CCK antagonist loxiglumide significantly accelerated gastric emptying of a liquid mixed meal and a glucose meal. Discrepant results with the antagonist MK329 are difficult to explain considering the marked acceleration of gastric emptying rates by the specific and potent antagonist MK329 shown in several animal studies. Taken together, current information favors the conclusion, however, that CCK mainly controls gastric emptying of the liquid but not the solid components. Thus, CCK is involved in the physiologic regulation of gastric emptying and gastric motility in man. Blocking CCK-A receptors accelerates gastric emptying of liquid meals and abolishes the gastrocolonic reflex. Therefore, CCK may play a role as a common regulator of postprandial gallbladder contraction and pancreatic enzyme secretion as well as of gastric emptying rates under certain conditions. Such common control would optimize the nutrient-to-digestive juices concentration ratio. The importance of endogenous CCK on gastric emptying of solid meals, however, is poorly understood and remains to be defined. Only very limited information is available on gastric motility. Much more work has to be done before a clear concept can be developed.

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Effect of Cholecystokinin on Gastric Motility in Humansa

Beglinger

1994

Annals of the New York Academy of Sciences

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Comparison of the Effects of Two Cholecystokinin-Receptor Antagonists, Loxiglumide and L-364,718, on the Pancreatic Secretory Response to Intraduodenal Tryptophan in Dogs

Niebergall-Roth

Teyssen

Wetzel

et al. 1996

Scandinavian Journal of Gastroenterology

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These findings indicate that in dogs 1) the pancreatic bicarbonate response to secretin is augmented by the hormone CCK; 2) L-364, 718 but not loxiglumide decreases pancreatic protein output during secretin; 3) endogenous released CCK is involved in the pancreatic bicarbonate response and is a major mediator of pancreatic protein response to intraduodenal tryptophan; and 4) the release of CCK by intraduodenal tryptophan is not influenced by loxiglumide and L-364, 718.

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Biological Actions of CCK in the Gastrointestinal Tract

Cited by 2 publications

References 31 publications

Effect of Cholecystokinin on Gastric Motility in Humansa

Effect of Cholecystokinin on Gastric Motility in Humansa

Comparison of the Effects of Two Cholecystokinin-Receptor Antagonists, Loxiglumide and L-364,718, on the Pancreatic Secretory Response to Intraduodenal Tryptophan in Dogs

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