2004
DOI: 10.1007/s00018-004-4302-x
|View full text |Cite
|
Sign up to set email alerts
|

Biological actions of the oligomers of ribonuclease A

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
44
0

Year Published

2006
2006
2012
2012

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 23 publications
(44 citation statements)
references
References 65 publications
0
44
0
Order By: Relevance
“…3) similarly to monomeric RNase A. Therefore, an improved interaction of the oligomers with the polyanionic cell surface followed by an efficient endocytosis was proposed for the nonetheless observed cytotoxicity (Libonati 2004). Like ?S-RNase, however, these artificial oligomers can dissociate which leads to the loss of their cytotoxic activity.…”
Section: Bs-rnase and Oligomeric Rnase Amentioning
confidence: 98%
See 2 more Smart Citations
“…3) similarly to monomeric RNase A. Therefore, an improved interaction of the oligomers with the polyanionic cell surface followed by an efficient endocytosis was proposed for the nonetheless observed cytotoxicity (Libonati 2004). Like ?S-RNase, however, these artificial oligomers can dissociate which leads to the loss of their cytotoxic activity.…”
Section: Bs-rnase and Oligomeric Rnase Amentioning
confidence: 98%
“…Artificial oligomerization of RNase A molecules as the consequence of an intermolecular exchange of their N-and/or C-termini ('domain swapping') results in higher-order, linear or cyclic multimers, which display antitumor and aspermatogenic but no embryotoxic activity (Libonati 2004). Analogously to BS-RNase one would expect that a disturbance of the RNase-RI interaction is responsible for the acquired cytotoxicity.…”
Section: Bs-rnase and Oligomeric Rnase Amentioning
confidence: 98%
See 1 more Smart Citation
“…7,8 Thus, despite some notable exceptions, such as that provided by a human-frog ribonuclease chimera, 9 RI action and cytotoxicity appear to be strongly anticorrelated. 6,10 In keeping with this indication, the production of aggregated forms of ribonucleases that are not amenable to RI binding for steric hindrance [11][12][13][14] may provide a way to produce proteins possessing enhanced cytotoxic effects. In this scenario, bovine seminal ribonuclease (BS-RNase) occupies a special position (Fig.…”
Section: Introductionmentioning
confidence: 93%
“…25 Surprisingly, these dimers display a detectable cytotoxic activity, although significantly smaller in comparison to BS-RNase. [11][12][13] However, it should be pointed out that the two units of NDRNaseA molecule 23,26 are not related by a 2-fold symmetry. Therefore, while the binding of one chain in the RI binding site can easily occur, the binding of the second subunit gives rise to severe interpenetration of the partner chain on the inhibitor molecule.…”
Section: Introductionmentioning
confidence: 97%