Biological activities and chemical composition of Morus leaves extracts obtained by maceration and supercritical fluid extraction

Radojković, Marija; Zeković, Zoran; Mašković, Pavle; Vidović, Senka; Mandić, Anamarija; Mišan, Aleksandra; Đurović, Saša

doi:10.1016/j.supflu.2016.05.004

Cited by 51 publications

(46 citation statements)

References 64 publications

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“…Concerning MAE, of the 12 identified and quantified compounds, these four correspond to 98% of the total quantified phenolic compounds in M. nigra extracts. These data are in accordance with previous work, which reported that the main contributors to the phenolic content of M. nigra products were rutin and chlorogenic acid. Sánchez‐Salcedo et al .…”

Section: Resultssupporting

confidence: 93%

“…This physical–chemical characteristic of the solvent expresses its capability to absorb microwave radiation and convert it to thermal energy . Bearing this in mind, and based also on previous studies, different pure solvents, i.e. water, methanol and ethanol, and mixtures of these solvents in several ratios (1:4, 1:1, 4:1 v/v; organic solvent:water) were tested using a sample weight of 0.50 g and a solvent volume of 20 mL at 100 °C for 20 min.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have demonstrated that mulberries are polyphenol‐rich plants with a large variety of positive health effects such as hyperglycemic, antinephritis, and anti‐inflammatory properties . In fact, there is information about M. nigra fruits, but very little about their leaves . Thus, the need of new sources of antioxidants, as feasible, natural and inexpensive alternatives to synthetic antioxidants, associated with the recognized health benefits reported for mulberry plants, promote interest in the exploitation of mulberry leaves for the agro‐food and other related industries.…”

Section: Introductionmentioning

confidence: 99%

“…Also, extraction in closed vessels can be accomplished at high temperatures, which increases the mass transfer of the analyte from the sample matrix, allowing rapid processes without deterioration of thermally unstable compounds . Supercritical CO 2 extraction is also a novel technique that has been explored for extraction of valuable compounds, which may be of importance for food and pharmaceutical industries, due to the several advantages (non‐toxic and non‐explosive properties, readily‐available and easy removable from the products) of using CO 2 as solvent . Recently, several groups have been investigating different extraction techniques to isolate bioactive components from mulberries .…”

Section: Introductionmentioning

confidence: 99%

“…9 In fact, there is information about M. nigra fruits, 5,10-14 but very little about their leaves. 10,12,15,16 Thus, the need of new sources of antioxidants, as feasible, natural and inexpensive alternatives to synthetic antioxidants, associated with the recognized health benefits reported for mulberry plants, promote interest in the exploitation of mulberry leaves for the agro-food and other related industries. Extraction is usually the limiting analytical step in the yield of bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

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Microwave‐assisted extraction of phenolic compounds from Morus nigra leaves: optimization and characterization of the antioxidant activity and phenolic composition

Radojković

Moreira

Soares

et al. 2018

J of Chemical Tech & Biotech

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BACKGROUND Morus nigra (mulberry) fruit has been reported as a source of bioactive compounds, although information about their leaves is very limited. Usually, they are considered wastes and have been traditionally used only for tea preparation. The main objective of this work was to explore the valorization of mulberry leaves by polyphenols microwave‐assisted extraction (MAE) and characterization of their antioxidant activity and phenolic composition. A 23 factorial design combined with response surface methodology were applied to characterize the effect of main microwave parameters on total phenolic content (TPC). RESULTS The optimized MAE conditions were 20 mL of ethanol:water (1:1; v/v), 120 °C, 28 min, 0.414 g and medium stirring speed. Under these conditions, TPC was 19.7 ± 2.0 mg gallic acid equivalents (GAE) g‐1 dry plant (DP), and antioxidant activity was 15.3 ± 1.0 mg ascorbic acid (AA) g‐1 DP (ferric reduction activity power –FRAP– assay), 18.6 ± 1.3 mg Trolox equivalents (TE) g‐1 DP (2,2‐diphenyl‐1‐picrylhydrazyl –DPPH– assay) and 186 ± 15 mg TE g‐1 DP (oxygen radical absorbance capacity –ORAC– assay). When compared with ultrasound extraction and Pharmacopeia reference method, MAE was more efficient, representing a valuable technology. Of the 13 compounds identified by HPLC, the most abundant were rutin, chlorogenic, β‐resorcylic and caffeic acids. CONCLUSION These results indicate that mulberry leaves are of potential interest for agro‐food industries as a new source of natural antioxidants. © 2017 Society of Chemical Industry

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Microwave‐assisted extraction of phenolic compounds from Morus nigra leaves: optimization and characterization of the antioxidant activity and phenolic composition

Radojković

Moreira

Soares

et al. 2018

J of Chemical Tech & Biotech

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Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts

Filip

Đurović

Blagojević

et al. 2020

Archiv der Pharmazie

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The main goal of this study was to establish the chemical profile of Osage orange (Maclura pomifera) leaf extracts, obtained by conventional maceration technique, and to examine its antimicrobial activity. The identification and quantification of the extract compounds were done using ultra‐high‐performance liquid chromatography, with a diode array detector coupled with triple‐quadrupole mass spectrometer and gas chromatography–mass spectrometry techniques. Thirty‐one polyphenolic compounds were detected and identified in the ethanolic extracts, whereby 5‐O‐caffeoylquinic acid was found to be the dominant compound. Among other compounds, pentacosane and palmitic acid were the most abundant compounds in the dichloromethane extract. The preliminary antimicrobial activity screening shows that Gram‐positive bacteria tend to be more sensitive to the investigated extracts. The highest antimicrobial activity was determined against Enterococcus faecalis ATCC 19433 and Listeria monocytogenes ATCC 35152. From these results, Osage orange leaves can be considered as plant material with significant antimicrobial properties.

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Supercritical Fluid and Ultrasound‐assisted Green Extraction Technologies for Catechin Recovery

et al. 2021

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The epimers of catechin include epicatechin, epigallocatechin and epigallocatechin gallate, and others. They are important bioactives that have salutary effects, and hence are valuable. For ascertaining biologically-safe and green extraction methods that are non-thermal, this review evaluates the efficiencies of ultrasound assisted extraction (UAE) and supercritical (SC) fluid extraction (with CO 2 ). Standalone SC-CO 2 could be preferred over UAE, given its selectivity (purer product, no co-extracts) and absence of downstream processing. GRAS solvents as water and ethanol or a hydro-alcoholic mix are preferable for UAE. However, considering the core competency of ultrasound in disrupting cell organelles, a tandem approach with sequential SC extraction is recommended to justify process economics and ensure quality yield of catechin using green technologies.

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Biological activities and chemical composition of Morus leaves extracts obtained by maceration and supercritical fluid extraction

Cited by 51 publications

References 64 publications

Microwave‐assisted extraction of phenolic compounds from Morus nigra leaves: optimization and characterization of the antioxidant activity and phenolic composition

Microwave‐assisted extraction of phenolic compounds from Morus nigra leaves: optimization and characterization of the antioxidant activity and phenolic composition

Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts

Supercritical Fluid and Ultrasound‐assisted Green Extraction Technologies for Catechin Recovery

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