Biological Activities of Carrageenan from Red Algae: a Mini Review

Udayakumar, Saranya; Girigoswami, Agnishwar; Girigoswami, Koyeli

doi:10.1007/s40495-023-00348-6

Cited by 7 publications

(1 citation statement)

References 81 publications

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“…They are anionic sulfated polysaccharides composed of alternating units of D-galactose and 3,6-anhydro-D-galactose linked by α-(1,3) and β-(1,4) glycosidic bonds and depending on the sulfation degree and the 3,6anhydro-D-galactose content, they are classified into three principal forms, namely kappa (κ)-, iota (ι)-, and lambda (λ)-carrageenans [10,15,[39][40][41][42][43]. Due to their low cost, resemblance to native glycosaminoglycans, and significant biological activities (antioxidant, anti-hyperlipidemic, anticoagulant, antiviral, antitumor, and immunomodulatory), they are widely used in the food, cosmetics, and pharmaceutical sectors [39,40,44,45]. Among them, κ-carrageenansexhibiting enhanced gelling properties, are considered a promising biopolymer for tissue regeneration and wound healing applications [10,44,46,47].…”

Section: Introductionmentioning

confidence: 99%

Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second Degree Burns

Statha,

Papaioannou,

Kikionis

et al. 2024

Preprint

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The bioactive marine sulfated polysaccharides ulvan and carrageenan, formulated in gels at 1.5, 5.0 and 10% w/w concentrations, were evaluated for their wound healing potential on second-degree burn wounds. The polysaccharide-based gels were administered on the burn-inflamed skin of hairless female SKH-hr2 mice, and the therapeutic effect of the various treatments was assessed based on histopathological analysis, the clinical condition of mice, photo-documentation, evaluation of biophysical skin parameters, and FT-IR spectroscopy.Clinical and histopathological assessment, as well as the reduction rate of the burn wound area, indicated that the 10% w/w carrageenan gel significantly enhanced wound healing, especially at the early stages of the healing process, recovering both the α-helix of collagen and the glycosaminoglycans configuration as evidenced by the FT-IR absorption bandsof skin in vivo and ex vivo. At later stages, the healing effect of the 5% w/w ulvan gel was also notably significant, indicating that carrageenan and ulvan wound dressing gels could potentially contribute to the efficient wound healing of burn wounds.

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