Biological activities of derivatized d-glucans: A review

Kagimura, Francini Yumi; Cunha, Mário Antônio Alves da; Barbosa, Aneli M.; Dekker, Robert F. H.; Malfatti, Carlos Ricardo Maneck

doi:10.1016/j.ijbiomac.2014.09.008

Cited by 107 publications

(67 citation statements)

References 125 publications

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“…Furthermore, some chemical modifications, such as sulfonylation, carboxymethylation, phosphorylation and acetylation, can determine an intensification of beneficial properties (Tranquilan-Aranilla et al, 2012;Jindal et al, 2013). Each of these aforementioned factors could influence a particular biological activity, including anticoagulant, antithrombotic, antioxidant, cholesterol reducing, anti-inflammatory, anti-cancer activities (Kagimura et al, 2015).…”

Section: β-Glucans and Their Physiological Activitiesmentioning

confidence: 99%

“…The efficacy of fungal glucans has been investigated also in the treatment of Alzheimer's disease, AIDS (Acquired Immunodeficiency Syndrome), multiple sclerosis and cardiovascular diseases (Kagimura et al, 2015). β-Glucans are even able to enhance the host defense against protozoa, bacteria, yeast and virus infections, such as those determined by Leishmania major, Candida albicans, Toxoplasma gondii, Staphylococcus aureus, Escherichia coli and Swine Influenza Virus (SIV) (Wiater et al, 2012;Vetvicka and Novak, 2011;Jung et al, 2004).…”

Section: β-Glucans and Their Physiological Activitiesmentioning

confidence: 99%

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β-Glucans and Probiotics

Arena¹,

Spano²,

Fiocco³

2017

American Journal of Immunology

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Abstract:In the recent decades, several health-promoting features have been ascribed to β-glucans. Biological properties such as anti-cancer, antiinflammatory and immune-modulating activity have been claimed for these polysaccharides. Moreover, when β-glucans were used in association with probiotic bacteria, prebiotic effects have been demonstrated, due to their ability to enhance growth, metabolism and/or beneficial activities of probiotics. This review shall present an overview of those studies, which have documented the diverse health-benefits of β-glucans and their association with probiotics.

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Section: β-Glucans and Their Physiological Activitiesmentioning

confidence: 99%

Section: β-Glucans and Their Physiological Activitiesmentioning

confidence: 99%

β-Glucans and Probiotics

Arena¹,

Spano²,

Fiocco³

2017

American Journal of Immunology

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“…Some biological properties have been identified for lasiodiplodan, including antiproliferative activity on MCF-7 breast cancer cells mediated by oxidative stress, AMP-Activated Protein Kinase (AMPK) and the Forkhead transcription factor (FOXO3a) Queiroz et al, 2015), hypoglycemic activity (Túrmina et al, 2012), antioxidant ability in vitro (Giese et al, 2015;Kagimura et al, 2015b) and protective activity against DNA damage induced by doxorubicin (Mello et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

“…Considering that the biological properties of polysaccharides are associated with their chemical structures, specific chemical modifications in the primary structure of these macromolecules may contribute to the potentiation of their functionalities (Kagimura et al, 2015b). In this context, in the present study lasiodiplodan was derivatized by carboxymethylation and characterized by FT-IR spectroscopy, carboxymethylation degree (DS), TG-DTA thermal analysis, X-ray diffraction and Scanning Electron Microscopy (SEM).…”

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confidence: 99%

Exocellular (1→6)-β-D-Glucan (Lasiodiplodan): Carboxymethylation, Thermal Behavior, Antioxidant and Antimicrobial Activity

Theis¹,

Calegari²,

Santos³

et al. 2017

American Journal of Immunology

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β-Glucans are biomacromolecules of industrial interest for its biological and technological properties, including ability to modify the rheology of food systems and different biological functionalities. In this study, lasiodiplodan an exocellular polysaccharide of the (1→6)-β-Dglucan type produced by the fungus Lasiodiplodia theobromae MMPI was obtained in a bench-scale bioreactor operated in discontinuous mode. Lasiodiplodan produced was derivatized by carboxymethylation and characterized by Fourier Transform Infrared spectroscopy (FT-IR), Thermogravimetry and Differential Thermal Analysis (TG-DTA), X-Ray Diffraction (XRD), scan electron microscopy (SEM) and their antioxidant and antimicrobial potential also was assessed. Two strong absorption bands in the regions of 1422 to 1598 cm −1 , resulting from symmetric and asymmetric stretching vibrations of the -COO-group respectively, were observed in the FT-IR spectrum of the derivatized sample and indicated the carboxymethylation of the macromolecule. TG-DTA curves indicated that native (LAS-N) and carboxymethylated (LAS-C) lasiodiplodan did not suffer significant changes in relation to the heating rates. Native and carboxymethylated lasiodiplodan demonstrated high thermal stability considering the usual standards of the pharmaceutical industry. The final temperature of thermal decomposition increased when the heating rate was increased and less number of steps for thermal decomposition was observed when air was substituted for nitrogen. XRD analysis showed the LAS-N and LAS-C have no crystalline structure, but carboxymethylation led to the arising of regions with certain molecular orientation in biopolymer structure. SEM analysis showed that the carboxymethylation promoted changes in biopolymer macrostructure, including breaking of the polymeric structure and arising of bubbles on the surface area. Carboxymethylation contributed to improving the polysaccharide's antioxidant capacity and LAS-C demonstrated antimicrobial activity against Candida tropicalis.

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“…β-Glucans are polysaccharides composed of D-glucose units linked by β-glucosidic bonds and may have linear or branched structures [1,2]. These biomacromolecules present peculiar physical, chemical and biological characteristics that are associated with their molecular structure and conformation, type of branching and glycosidic bonds, which makes them interesting for different applications in the medical, pharmaceutical, cosmetic and food sectors [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

Sulfonation of (1→6)-β-D-Glucan (Lasiodiplodan) and Its Antioxidant and Antimicrobial Potential

Calegari¹,

Santos²,

Teixeira³

et al. 2017

JPP

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Abstract:The objective of this study was to investigate the sulfonation of (1→6)-β-D-glucan (lasiodiplodan) as a potentiating mechanism for biological functionalities. Lasiodiplodan was sulfonated by the chlorosulfonic acid-pyridine method. The modified exopolysaccharide was characterized by FT-IR and 13 C NMR spectroscopy, X-ray diffraction and SEM. Antioxidant activity was assessed by the methods of H 2 O 2 and OH radical removal and reducing power. Antimicrobial potential was evaluated by the broth-microdilution method. Sulfonation resulted in a derivative with DS of 0.24. FT-IR analysis indicated the introduction of sulfonyl groups in the macromolecule structure through specific bands in the regions of 1,240 cm -1 and 810 cm -1 . 13 C NMR analysis suggested that sulfonation occurred at carbon 2 of the glucose residue. Sulfonation led to morphological changes in the structure of the biopolymer resulting in a heterogeneous structure with the presence of fibrils. Derivatization promoted an increase in the antioxidant ability of the macromolecule, with a high OH removal potential (74.32%). Bacteriostatic activity against E. coli (Escherichia coli) and S. enterica (Salmonella enterica) typhimurium and fungicidal activity against C. albicans (Candida albicans) and C. tropicalis (Candida tropicalis) were found in the sulfonated sample. Sulfonation potentiated the antioxidant and antimicrobial activities of the biomacromolecule, suggesting that it is a potentiating mechanism of biological functions.

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Biological activities of derivatized d-glucans: A review

Cited by 107 publications

References 125 publications

β-Glucans and Probiotics

β-Glucans and Probiotics

Exocellular (1→6)-β-D-Glucan (Lasiodiplodan): Carboxymethylation, Thermal Behavior, Antioxidant and Antimicrobial Activity

Sulfonation of (1→6)-β-D-Glucan (Lasiodiplodan) and Its Antioxidant and Antimicrobial Potential

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Biological activities of derivatized d-glucans: A review

Cited by 107 publications

References 125 publications

&beta;-Glucans and Probiotics

&beta;-Glucans and Probiotics

Exocellular (1&rarr;6)-&beta;-D-Glucan (Lasiodiplodan): Carboxymethylation, Thermal Behavior, Antioxidant and Antimicrobial Activity

Sulfonation of (1→6)-β-D-Glucan (Lasiodiplodan) and Its Antioxidant and Antimicrobial Potential

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β-Glucans and Probiotics

β-Glucans and Probiotics

Exocellular (1→6)-β-D-Glucan (Lasiodiplodan): Carboxymethylation, Thermal Behavior, Antioxidant and Antimicrobial Activity