2022
DOI: 10.3389/fphar.2022.830103
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Biological activities of meroterpenoids isolated from different sources

Abstract: Meroterpenoids are natural products synthesized by unicellular organisms such as bacteria and multicellular organisms such as fungi, plants, and animals, including those of marine origin. Structurally, these compounds exhibit a wide diversity depending upon the origin and the biosynthetic pathway they emerge from. This diversity in structural features imparts a wide spectrum of biological activity to meroterpenoids. Based on the biosynthetic pathway of origin, these compounds are either polyketide-terpenoids o… Show more

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Cited by 26 publications
(11 citation statements)
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“…Synthesized by diverse organisms, including algae, meroterpenoids exhibit structural diversity based on their origin and biosynthesis. This diversity underpins their broad spectrum of biological activities, encompassing anti-cholinesterase, anti-diabetic, antioxidative, anti-inflammatory, and antineoplastic properties, alongside renal, cardioprotective, and neuroprotective effects [ 7 ]. Sargassum species are also rich sources of meroterpenoid compounds, including sargahydroquinoic acid (SHQA), sargachromenol (SCM), and sargaquinoic acid (SQA) [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Synthesized by diverse organisms, including algae, meroterpenoids exhibit structural diversity based on their origin and biosynthesis. This diversity underpins their broad spectrum of biological activities, encompassing anti-cholinesterase, anti-diabetic, antioxidative, anti-inflammatory, and antineoplastic properties, alongside renal, cardioprotective, and neuroprotective effects [ 7 ]. Sargassum species are also rich sources of meroterpenoid compounds, including sargahydroquinoic acid (SHQA), sargachromenol (SCM), and sargaquinoic acid (SQA) [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Chromane/chromene meroterpenoids have displayed cytotoxic activity against different tumor cell lines, as well as antioxidant and antimicrobial activities. Furthermore, they have been reported to inhibit various enzymes, including protein tyrosine phosphatase 1B (PTP1B), butyrylcholinesterase (BChE), β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and protein farnesyl transferase (PFTase). , …”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, they have been reported to inhibit various enzymes, including protein tyrosine phosphatase 1B (PTP1B), butyrylcholinesterase (BChE), β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and protein farnesyl transferase (PFTase). 1 , 18 …”
Section: Introductionmentioning
confidence: 99%
“…Thus, PGE 2 and its mediated activities are the specific target for pain relief, and anti-inflammation treatments [ 9 ]. Fuloria et al have discussed about 590 meroterpenoids (polyketide or non-polyketide terpenoids) and their biological activities (anticholinesterase, COX-2 inhibition, antioxidative, and antibacterial), in which 39%, 36%, and 25% were from fungi, plants and marine sources including sponges and algae [ 10 ].…”
Section: Introductionmentioning
confidence: 99%