Biological Activities of Organic Extracts of the Genus Aristolochia: A Review from 2005 to 2021

Lerma-Herrera, Martín A; Beiza-Granados, Lidia; Ochoa‐Zarzosa, Alejandra; López‐Meza, Joel E.; Navarro-Santos, Pedro; Herrera-Bucio, Rafael; Aviña-Verduzco, Judit A.; García-Gutiérrez, Hugo A.

doi:10.3390/molecules27123937

Cited by 12 publications

(5 citation statements)

References 112 publications

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“…The informative data obtained from the analysis are summarized in Table S1 and Supplementary HPLC-UV and HRMS data. Magnoflorine (2), an aporphine derivative, and two aristolochic acids (AA)-I (7) and AA-II (6) were identified by complete concurrence with standard compounds. The mass spectrometric behavior of AAs was studied using standard compounds (AA-I and AA-II) and previously published information [56][57][58].…”

Section: The Effect Of Rolc and Rolb On Accumulation Of Phenanthroic ...mentioning

confidence: 99%

“…Consequently, Aristolochia plants are considered "natural factories" for producing these phytochemicals [5]. For centuries, Aristolochia species have been utilized in traditional medicine across Asia to treat various ailments, such as arthritis, rheumatism, angina, and myocardial infarction, alone or in combination with other herbs [6]. Studies have also suggested their potential as analgesics, antimalarials, antibacterial agents, and antidotes for snake bites [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…For centuries, Aristolochia species have been utilized in traditional medicine across Asia to treat various ailments, such as arthritis, rheumatism, angina, and myocardial infarction, alone or in combination with other herbs [6]. Studies have also suggested their potential as analgesics, antimalarials, antibacterial agents, and antidotes for snake bites [6,7]. However, certain Aristolochia species have been associated with an elevated risk of urinary tract cancer and renal interstitial fibrosis [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Production of Nitrogenated Metabolites with Anticancer Potential in Aristolochia manshuriensis Hairy Root Cultures

Shkryl,

Tchernoded,

Yugay

et al. 2023

IJMS

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Aristolochia manshuriensis is a relic liana, which is widely used in traditional Chinese herbal medicine and is endemic to the Manchurian floristic region. Since this plant is rare and slow-growing, alternative sources of its valuable compounds could be explored. Herein, we established hairy root cultures of A. manshuriensis transformed with Agrobacterium rhizogenes root oncogenic loci (rol)B and rolC genes. The accumulation of nitrogenous secondary metabolites significantly improved in transgenic cell cultures. Specifically, the production of magnoflorine reached up to 5.72 mg/g of dry weight, which is 5.8 times higher than the control calli and 1.7 times higher than in wild-growing liana. Simultaneously, the amounts of aristolochic acids I and II, responsible for the toxicity of Aristolochia species, decreased by more than 10 fold. Consequently, the hairy root extracts demonstrated pronounced cytotoxicity against human glioblastoma cells (U-87 MG), cervical cancer cells (HeLa CCL-2), and colon carcinoma (RKO) cells. However, they did not exhibit significant activity against triple-negative breast cancer cells (MDA-MB-231). Our findings suggest that hairy root cultures of A. manshuriensis could be considered for the rational production of valuable A. manshuriensis compounds by the modification of secondary metabolism.

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Section: The Effect Of Rolc and Rolb On Accumulation Of Phenanthroic ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced Production of Nitrogenated Metabolites with Anticancer Potential in Aristolochia manshuriensis Hairy Root Cultures

Shkryl,

Tchernoded,

Yugay

et al. 2023

IJMS

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“…Various species of Aristolochia have been reported to show antimicrobial activities [20]. Table 2 shows a varying degree of antimicrobial activity demonstrated by the four A. albida root extracts when investigated against the five microorganisms.…”

Section: Key: (+) = Slightly Present (++) = Moderately Present (+++) ...mentioning

confidence: 99%

Phytochemical Analysis and Investigation of the Antibacterial and Antioxidant Activities of Aristolochia albida Root Extracts

N. N.,

I.Y.,

H.M.

et al. 2024

Chem. Sci. Int. J.

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Introduction: The increasing prevalence of antibacterial resistance has led to the deliberate laborious exploration of plants for new potent drugs. Over the years, plants have served as rich reservoirs of medicinal components that are used for the management of various ailments because of the belief that they exhibit minimal side effects and improved efficacy than other synthetic counterparts. Aim: The aim of this research is to evaluate the phytochemical content, antimicrobial and antioxidant activities of the root extracts of A. albida; a shrub that is commonly used in North Central Nigeria for the management of some microbial infections, snakebite, stomach ailments and pain. Methods: The roots of A. albida were harvested, washed with clean water, dried, ground, and extracted with hexane, ethyl acetate, methanol and water using the Soxhlet extractor. The phytochemical screening which indicated the presence of alkaloids, anthraquinones, flavonoids, terpenes, cardiac glycosides and tannins was done using standard methods. The antimicrobial activity was tested using agar well diffusion technique against five human pathogens namely: Staphylococcus aureus, Escherichia coli, Salmonella typhi, Streptococcus pneumonae and Pseudomonas aeruginosa while the antioxidant activities were tested using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. Results: All extracts showed the antibacterial activity against all test organisms at all concentrations used. At 50 mg/cm3, S. aureus showed high sensitivities with 23.00 mm, 20.50 mm, 22.00 mm and 18.50 mm diameter of zone of inhibition for hexane, ethyl acetate, methanol and water extracts respectively. The results obtained in this study indicated that the MICs of the four extracts were weak (12.50-200.0 mg/cm3) when compared to the MIC range of most commonly available antibiotics having a range of 0.015-0.107 mg/cm3. The extracts demonstrated minimum bactericidal concentration (MBC) range of 400-50 mg/cm3. All the extracts showed a DPPH scavenging activity which increased with increase in sample concentration. Among the solvents used, hexane extract gave the highest antioxidant activity, IC50 = 0.032 mg/cm3. Ethyl acetate and water extracts of A. albida had IC50 = 0.05 mg/cm3. Conclusion: The results reported in this research work highlighted the potential use of A. albida extract as a source of phytochemicals with promising antimicrobial and antioxidant activities.

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“…Aristolochia is used especially in cases of gout, arthritis, rheumatism, and skin diseases, and can also be used to treat snakebites (Gifford et al, 2017;Perry & Metzger, 1980). A recent review on biological activities of the Aristolochia genus recognizes an even larger spectrum of effects of traditional preparations from different species, including anticancer, antibacterial and antiparasitic activities, among others (Lerma-Herrera et al, 2022). The phytochemistry of the genus has been widely investigated but lacks a systematic approach, usually including various organs from different plant species.…”

Section: Introduction 1the Genus Aristolochia: Between Poison and Med...mentioning

confidence: 99%

Ethnomedical uses of Yawar Panga (Aristolochia didyma) in a therapeutic community dedicated to the treatment of drug addiction in the Peruvian Amazon

Politi¹,

Simonet²,

Kube³

et al. 2023

NRFHH

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Aristolochia didyma (Yawar Panga) and other Aristolochia species are used as traditional herbal remedies with potent emetic properties. Scientific data for such Yawar Panga species, however, are scarce in the literature. The aim of this study was to describe the use of Yawar Panga within the context of the therapeutic community Takiwasi, in which the plant is used as part of the protocol for the rehabilitation of individuals with drug addiction. Fieldwork with experts in the administration of Yawar Panga at Takiwasi Center, as well as a retrospective qualitative analysis of experiences with this plant remedy in a residential inpatient population were performed. In-silico analysis of the main constituents of A. didyma as represented in the literature was completed in order to identify its putative pharmacological targets. The therapists interviewed consider Yawar Panga to be the most potent purga at Takiwasi and consider it especially useful in attenuating addiction withdrawal syndrome. From the patient’s perspective, this plant induces strong physical effects, and commonly precipitates effects in the oneiric and emotional dimensions. GABA B seems to be the receptor involved in the emesis induced by the phytochemicals contained in this plant species. Despite some relevant concerns related to the safety of the genus Aristolochia in modern western pharmacopoeias, some species, including A. didyma, are routinely used in the context of traditional herbal medicine in the Peruvian Amazon. Further phyto-pharmacological investigations would be helpful to elaborate this species’ medical utility, especially within the context of addiction treatment.

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Biological Activities of Organic Extracts of the Genus Aristolochia: A Review from 2005 to 2021

Cited by 12 publications

References 112 publications

Enhanced Production of Nitrogenated Metabolites with Anticancer Potential in Aristolochia manshuriensis Hairy Root Cultures

Enhanced Production of Nitrogenated Metabolites with Anticancer Potential in Aristolochia manshuriensis Hairy Root Cultures

Phytochemical Analysis and Investigation of the Antibacterial and Antioxidant Activities of Aristolochia albida Root Extracts

Ethnomedical uses of Yawar Panga (<i>Aristolochia didyma</i>) in a therapeutic community dedicated to the treatment of drug addiction in the Peruvian Amazon

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