Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa)

Suzuki, Koji; Terasawa, Masahiro

doi:10.3390/md18040228

Cited by 29 publications

(22 citation statements)

References 57 publications

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“…Albumin carries sphingosine-1 phosphate to the endothelium, which inhibits syndecan-1 shedding ( 62 ). Further, rhamnan sulfate, a polysaccharide extracted from the green algae M. nitidum has antiviral and antithrombotic properties ( 63 , 64 ). Sevoflurane, which is used during anesthesia, has been shown to be protective against ischemia- reperfusion injury of the glycocalyx ( 65 ).…”

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confidence: 99%

Glycocalyx as Possible Limiting Factor in COVID-19

et al. 2021

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confidence: 99%

Glycocalyx as Possible Limiting Factor in COVID-19

et al. 2021

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“…Suzuki and Terasawa 197 recently reviewed the many beneficial biological activities of rhamnan sulfate (RS), a sulfated polysaccharide extracted from the green algae M. nitidum . RS is found to have antiviral and antithrombotic activities.…”

Section: Part B: the Role Of The Glycocalyx In Vascular Related Diseamentioning

confidence: 99%

The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases

Weinbaum

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et al. 2020

Cardiovasc Eng Tech

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Purpose In 2007 the two senior authors wrote a review on the structure and function of the endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9:121–167, 2007). Since then there has been an explosion of interest in this hydrated gel-like structure that coats the luminal surface of endothelial cells that line our vasculature due to its important functions in (A) basic vascular physiology and (B) vascular related diseases. This review will highlight the major advances that have occurred since our 2007 paper. Methods A literature search mainly focusing on the role of the glycocalyx in the two major areas described above was performed using electronic databases. Results In part (A) of this review, the new formulation of the century old Starling principle, now referred to as the Michel–Weinbaum glycoclayx model or revised Starling hypothesis, is described including new subtleties and physiological ramifications. New insights into mechanotransduction and release of nitric oxide due to fluid shear stress sensed by the glycocalyx are elaborated. Major advances in understanding the organization and function of glycocalyx components, and new techniques for measuring both its thickness and spatio-chemical organization based on super resolution, stochastic optical reconstruction microscopy (STORM) are presented. As discussed in part (B) of this review, it is now recognized that artery wall stiffness associated with hypertension and aging induces glycocalyx degradation, endothelial dysfunction and vascular disease. In addition to atherosclerosis and cardiovascular diseases, the glycocalyx plays an important role in lifestyle related diseases (e.g., diabetes) and cancer. Infectious diseases including sepsis, Dengue, Zika and Corona viruses, and malaria also involve the glycocalyx. Because of increasing recognition of the role of the glycocalyx in a wide range of diseases, there has been a vigorous search for methods to protect the glycocalyx from degradation or to enhance its synthesis in disease environments. Conclusion As we have seen in this review, many important developments in our basic understanding of GCX structure, function and role in diseases have been described since the 2007 paper. The future is wide open for continued GCX research.

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“…This polysaccharide is extracted by hot water, though is poorly water soluble [98]. Several studies exhibit its biological activities such as antiviral, anticoagulant, antitumor, anti-inflammatory, anti-hypercholesterolemic, anti-obesity and antihypertensive properties.…”

Section: Sulfated Polysaccharidesmentioning

confidence: 99%

“…Several studies exhibit its biological activities such as antiviral, anticoagulant, antitumor, anti-inflammatory, anti-hypercholesterolemic, anti-obesity and antihypertensive properties. Further, M. nitidum-derived rhamnan sulfate is considered to promote the human health [98].…”

Section: Sulfated Polysaccharidesmentioning

confidence: 99%

Innovation in the Seafood Sector through the Valorization of By-Products

Moosavi‐Nasab¹,

Oliyaei²,

Eun³

et al. 2021

Innovation in the Food Sector Through the Valorization of Food and Agro-Food by-Products

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Aquatic, marine and algae, is reservoir of bioactive compounds, which have considerable potential to supply novel ingredients toward the development of commercial functional food products. Meanwhile, several valuable by-products generate during the manufacturing process. Seafood is still an intact reservoir of valuable compounds with significant potential to provide unique compounds applicable in functional food development. Seafood, as an important part of the diet all around the world, can be used as a source of functional components that are positively affecting the human health. Annually, 50–80 percent of the seafood processing is discarded as waste every year. Algae are also the novel natural resources for their biological and pharmacological properties. This chapter will be discussing the innovations in seafood and algae sector through the valorization of their by-products. Firstly, protein production, its characterization and the protein hydrolysates derived from seafood will be reviewed. Subsequently, bioactivity of the peptides obtained from these protein hydrolysates and other bioactive compounds such as carotenoid compounds derived from seafood including fish, shrimp, alga, and so on will be included. Finally, the main components of algae including sulfated polysaccharides, pigments and proteins will be surveyed.

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Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa)

Cited by 29 publications

References 57 publications

Glycocalyx as Possible Limiting Factor in COVID-19

Glycocalyx as Possible Limiting Factor in COVID-19

The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases

Innovation in the Seafood Sector through the Valorization of By-Products

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