Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health

Denev, Petko; Kratchanova, Maria; Čı́ž, Milan; Lojek, Antonı́n; Vašíček, Ondřej; Nedelcheva, P.; Blazheva, Denica; Toshkova, Reneta; Gardeva, Elena; Yossifova, L.; Hyršl, Pavel; Vojtek, Libor

doi:10.1016/j.foodchem.2014.02.022

Cited by 89 publications

(68 citation statements)

References 26 publications

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“…This finding suggests that the antioxidant components in the blueberry diet play a major role in the cellular defense mechanisms and protect against oxidative damage by scavenging the free radicals. Since blueberries are rich sources of anthocyanin polyphenols, they can act as antioxidant and anti-inflammatory molecules and confer considerable potential protective effects against development of inflammation related diseases [14, 17, 19–21]. …”

Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD)

Ebenezer

Wilson

et al. 2016

PLoS ONE

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Post-traumatic stress disorder (PTSD) is a trauma and stressor-related disorder that results in a prolonged stress response. It is associated with increased oxidative stress and inflammation in the prefrontal cortex (PFC) and hippocampus (HC). The only approved therapy for PTSD is selective serotonin re-uptake inhibitors (SSRIs), but their efficacy is marginal. Recently, we demonstrated that over-production of norepinephrine (NE) as the possible reason for the lack of efficacy of SSRIs. Hence, there is a need for novel therapeutic approaches for the treatment of PTSD. In this study, we investigated the anti-inflammatory role of blueberries in modulating inflammatory markers and neurotransmitter levels in PTSD. Rats were fed either a blueberry enriched (2%) or a control diet. Rats were exposed to cats for one hour on days 1 and 11 of a 31-day schedule to simulate traumatic conditions. The rats were also subjected to psychosocial stress via daily cage cohort changes. At the end of the study, the rats were euthanized and the PFC and HC were isolated. Monoamines were measured by high-performance liquid chromatography. Reactive oxygen species (ROS), gene and protein expression levels of inflammatory cytokines were also measured. In our PTSD model, NE levels were increased and 5-HT levels were decreased when compared to control. In contrast, a blueberry enriched diet increased 5-HT without affecting NE levels. The rate limiting enzymes tyrosine hydroxylase and tryptophan hydroxylase were also studied and they confirmed our findings. The enhanced levels free radicals, gene and protein expression of inflammatory cytokines seen in the PTSD group were normalized with a blueberry enriched diet. Decreased anxiety in this group was shown by improved performance on the elevated plus-maze. These findings indicate blueberries can attenuate oxidative stress and inflammation and restore neurotransmitter imbalances in a rat model of PTSD.

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Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD)

Ebenezer

Wilson

et al. 2016

PLoS ONE

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“…On the other hand, the Folin-Ciocalteu reagent is nonspecific to phenolic compounds and can react with a wide range of thiol derivatives, some vitamins and aromatic amino acids [30]. According to the literature data, proanthocyanidins are the dominant phenolic components of black chokeberry fruit and chokeberry juices [2,3]. Additionally, Wu et al [4] found that chokeberry fruits contained only procyanidins and polymers with DP > 10 accounted for nearly 82 % of total procyanidins content.…”

Section: Discussionmentioning

confidence: 99%

“…Black chokeberry (Aronia melanocarpa) fruit is known as a potent source of phenolic compounds, especially anthocyanins and proanthocyanidins [1][2][3][4]. Nevertheless, chokeberry berries are rarely consumed directly because of their specific organoleptic properties, such as unpleasant astringent taste and their smell of bitter almonds [5].…”

Section: Introductionmentioning

confidence: 99%

Comparison of in vitro anti-lipase and antioxidant activities, and composition of commercial chokeberry juices

Sosnowska

Podsędek

Kucharska

et al. 2015

Eur Food Res Technol

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“…Rose hips contained vanillic acid, p-coumaric acid and ferulic acid in important concentrations, while green tea had high concentrations of syringic acid. Denev et al [40] studied the concentration of major polyphenol and anthocyanin contents of fruit extract and the antioxidant properties of six fruits: rose hip ( Rosa canina ), rowanberry ( Serbus aucuparia ), hawthorn ( Crataegus monogyna ), chokeberry ( Aronia melanocarpa ), blackcurrant ( Ribes nigrum ), and blueberry ( Vaccinium myrtillus ). They found that rose hips had chlorogenic acid but in lower concentrations than rowanberry and chokeberry, and that the rose fruit showed a high concentration of rutin but no anthocyanins were found.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

143

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Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.

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Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health

Cited by 89 publications

References 26 publications

The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD)

The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD)

Comparison of in vitro anti-lipase and antioxidant activities, and composition of commercial chokeberry juices

Therapeutic Applications of Rose Hips from Different Rosa Species

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