Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Zheng, Ruihong; Li, Shoujie; Zhang, Xuan; Zhao, Changqi

doi:10.3390/ijms22020959

Cited by 96 publications

(56 citation statements)

References 139 publications

(330 reference statements)

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“…Due to their unique ecological niche, endophytic fungi have become important sources of natural products to be screened for with unique chemical structures and biological activity [ 3 , 4 ]. Therefore, the natural product screening of endophytic fungi is currently a hot research topic [ 5 , 6 , 7 , 8 , 9 ]. In this sense, it is worth undertaking a constant search for novel compounds from endophytic fungal sources and paying attention to discovering potential drug candidates.…”

Section: Introductionmentioning

confidence: 99%

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Yang

Liang

Zhang

et al. 2022

JoF

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The secondary metabolites of Phaeosphaeria sp. LF5, an endophytic fungus with acetylcholinesterase (AChE) inhibitory activity isolated from Huperzia serrata, were investigated. Their structures and absolute configurations were elucidated by means of extensive spectroscopic data, including one- and two-dimensional nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) analyses, and calculations of electronic circular dichroism (ECD). A chemical study on the solid-cultured fungus LF5 resulted in 11 polyketide derivatives, which included three previously undescribed derivatives: aspilactonol I (4), 2-(1-hydroxyethyl)-6-methylisonicotinic acid (7), and 6,8-dihydroxy-3-(1′R, 2′R-dihydroxypropyl)-isocoumarin (9), and two new natural-source-derived aspilactonols (G, H) (2, 3). Moreover, the absolute configuration of de-O-methyldiaporthin (11) was identified for the first time. Compounds 4 and 11 exhibited inhibitory activity against AChE with half maximal inhibitory concentration (IC50) values of 6.26 and 21.18 µM, respectively. Aspilactonol I (4) is the first reported furanone AChE inhibitor (AChEI). The results indicated that Phaeosphaeria is a good source of polyketide derivatives. This study identified intriguing lead compounds for further research and development of new AChEIs.

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Section: Introductionmentioning

confidence: 99%

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Yang

Liang

Zhang

et al. 2022

JoF

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“…All of these applications evidence an extremely high diversity in the nature of the metabolites produced by fungal endophytes, many of them with antifungal properties. A complete description of the active metabolites produced by fungal endophytes and the nature of their bioactivity can be found in the review carried out by Zheng et al [ 93 ].…”

Section: Secondary Metabolites From Fungal Organismsmentioning

confidence: 99%

Metabolites Produced by Fungi against Fungal Phytopathogens: Review, Implementation and Perspectives

Rodrigo

García-Latorre

Santamaría

2021

Plants

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Many fungi, especially endophytes, have been found to produce multiple benefits in their plant hosts, with many of these benefits associated with the protection of plants against fungal diseases. This fact could be used in the development of new bio-products that could gradually reduce the need for chemical fungicides, which have been associated with multiple health and environmental problems. However, the utilization of the living organism may present several issues, such as an inconsistency in the results obtained and more complicated management and application, as fungal species are highly influenced by environmental conditions, the type of relationship with the plant host and interaction with other microorganisms. These issues could be addressed by using the bioactive compounds produced by the fungus, in cases where they were responsible for positive effects, instead of the living organism. Multiple bioactive compounds produced by fungal species, especially endophytes, with antifungal properties have been previously reported in the literature. However, despite the large amount of these metabolites and their potential, extensive in-field application on a large scale has not yet been implemented. In the present review, the main aspects explaining this limited implementation are analyzed, and the present and future perspectives for its development are discussed.

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“…Members of the genus Alternaria are known to produce a wide range of phytotoxic secondary metabolites which affect a large number of plants on which the fungus is found [26]. These phytotoxins include alternariol, alternariol monomethyl ether (AME), altenuene, altenuic acid, tenuazonic acid (TA), tentoxin, alternaric acid, AKtoxin and AAL-toxin and posses a broad range of biological and metabolic effects [27,28]. The metabolites produced by Alternaria exhibit a wide variety of biological activities ranging from phytotoxic, cytotoxic, and antimicrobial activities.…”

Section: Alternaria Sp Secondary Metabolites and Their Biological Activitiesmentioning

confidence: 99%

Allergen, pathogen, or biotechnological tool? The dematiaceous fungi Alternaria what’s for it and what’s on it?

Elkhateeb¹,

Kolaibe²,

Elkhateeb³

et al. 2021

JPPR

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Fungi are rich sources of biologically active natural compounds, which are used in the manufacturing of wide range of clinically important drugs. Alternaria is a fungal genus that belongs to family Pleosporaceae, and has been known as a promising secondary metabolites producer. However the same fungus showed harmful pathogenicity against different plants causing crops economical losses, and is a common allergen in humans, growing indoors and causing hay fever or hypersensitivity reactions. Alternaria is a multicultural fungal genus widely distributing in soil and organic matter. It includes saprophytic, endophytic and pathogenic species. This review aims to briefly summarize the structurally different metabolites produced by Alternaria fungi, as well as their occurrences, biological activities and functions.

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Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Cited by 96 publications

References 139 publications

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Polyketide Derivatives from the Endophytic Fungus Phaeosphaeria sp. LF5 Isolated from Huperzia serrata and Their Acetylcholinesterase Inhibitory Activities

Metabolites Produced by Fungi against Fungal Phytopathogens: Review, Implementation and Perspectives

Allergen, pathogen, or biotechnological tool? The dematiaceous fungi Alternaria what’s for it and what’s on it?

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