Biological activity and enzymatic hydrolysis of retinoates in vitro

Salo, Maija-Liisa; Kiviranta, J.; Knuutila, V.; Kangas, Lauri; Vuorela, Heikki

doi:10.1016/0928-0987(94)00076-c

Cited by 1 publication

(1 citation statement)

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“…It was observed that the injected malignant lymphoma cells failed to survive in the guinea pig, and that guinea pig serum prevented the survival of lymphoma cells injected into mice. The explanation lied on the fact that the guinea pig serum contains the enzyme L-asparaginase which destroys the amino acid L-asparagin, which is necessary for the formation of nucleic acids by hydrolysis L-asparagine to aspartic acid and ammonia [1].…”

Section: Introductionmentioning

confidence: 99%

Amino Acids Diets as Model for Investigating Cancer Induced by Acrylamide Produced during Wrong Food Cooking

Hamad¹,

Hafez²,

Khaled³

et al. 2018

SOJB

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Starvation could be the cheapest solution for cancer treatment. Alternatively, controlled amino acids diets could be another solution. Starving the body from certain amino acids as well as changing the amount of some used amino acids controlled diet is the main idea of this study. In this study, acrylamide was used to induce cancer in the rats. Acrylamide is a cancer causative agent. We utilize it through a diet containing potato. To evaluate the effect of such change in the cancer cells induced by acrylamide in rats, five diets different in their amino acids constituents were designed. Rats were feed on the different amino acids diets to investigate their effect on the cancer induced by the acrylamide. Biochemical analysis for the liver functions represented by GOT, GPT and ALP assays as well as the amount of the produced billirubin and cholesterol were performed. Additionally the weight and the histo-pathological changes in each of the liver, lung and kidney tissues were investigated. To evaluate the effect of the treatments on the molecular level P 53 , expression level as a cancer genetic marker were investigated. The results were subjected to logical and statistical analysis. Statistical analyses for the data using LSD were generated. The data obtained from this study prove that the amino acids controlled diets could incapsitate for some extend the development of the cancer cells. In this study, protection against the formation of the cancer is also reported. The main explanation is that such controlled diet might be able to reduce the growth rate of the cancer cells or give suitable time to the cell self-killing mechanism to be complement with the cancer cells replication rate and growing time. Depleting seven amino acids from the diet show the best result (group E). The study prove that vegetarian, those how fasting or starving are safer and can resist cancer. However they are more susceptible to exogenous source of toxins such as the acrylamide than those who include amino acids in their diets. Controlled amino acids diets show different results according to the amino acids composition. This study recommended use of controlled amino acids to save our health. And more study for the role of the controlled amino acids diets either in cancer protection, prevention or treatment as well as which amino acid(s) should be depleted from which cancer cells should be conducted.

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Section: Introductionmentioning

confidence: 99%