Biological activity evaluation of dibenzilbutirolactones lignans derivatives against Leishmania braziliensis

In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae)

“…1) were in agreement with the data published previously, allowing the identification of lignans: machilin-G (1a) antimalarial (Zhang et al, 2001), antitumor (Bastos et al, 1996) and antiinflammatory (Souza et al, 2004) activities. Recently, our group reported significant trypanocidal and antileishmanial activities of dibenzylbutyrolactone lignans Royo et al, 2003;Bastos et al, 1999).…”

In vitro and in vivo anthelmintic activity of (−)-6,6′-dinitrohinokinin against schistosomula and juvenile and adult worms of Schistosoma mansoni

“…Among the several classes of plant-derived secondary metabolites, lignans constitute a class that displays a wide spectrum of biological activities (Apears et al, 2003), including their action against parasites that cause neglected tropical diseases such as trypanosomiasis (Saraiva et al, 2007;Esperandim et al, 2010) and leishmaniasis (Royo et al, 2003). In a previous work, our group found that (-)-cubebin from Piper cubeba (used in the semi-synthesis of DNK in the present work) did not kill Schistosoma mansoni but minimized the movement that occurred at concentrations of 100 and 200…”

Avaliação da atividade leishmanicida in vitro de plantas medicinais

“…Já foi relatada a atividade leishmanicida de terpenóides Camacho et al, 2000), aminoglicosteróides e aminosteróides (Kam et al, 1997), naftoquinonas (Fournet et al, 1992;Kayser et al, 2000), chalconas (Chen et al, 1993;Boeck et al, 2006), glicosídios iridóides (Mittal et al, 1998), fl avonóides (Araújo et al, 1998), lignanas (Barata et al, 2000;Royo et al, 2003) e de alcalóides (Mahiou et al, 1994;Fournet et al, 1996;Queiroz, et al, 1996). Apesar dos vários estudos nesta área, ainda existem muitas espécies vegetais com potencial atividade leishmanicida a serem avaliadas.…”