Biological Activity of Alantolactones in Experiments on Cells

Клочков, С. Г.; Pukhov, S. A.; Neganova, Margarita E.; Dubrovskaya, E. S.; Anikina, L.A.; Afanasyeva, S. V.; Semakov, A. V.

doi:10.18097/bmcrm00047

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Fig 2 Structures Of Isomeric Alantolactones1

Polyhydroxyl-containing α-Methylene-γ-lactones1

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2021

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“…Lactones 1 and 2 (as well as 5α-epoxyalantolactone 10) cause a significant increase in the activity of quinone reductase (chemopreventive biomarker) in Hepa1c1c7 and BPRc1 cells [58]. Our research group determined IC50 data for alantolactones on the following cell lines: MCF7, MS, HCT116 [59], A549, RD и HEK293 [60].…”

Section: Fig 2 Structures Of Isomeric Alantolactonesmentioning

confidence: 99%

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Eudesmane Sesquiterpene Lactones of the Genus Inula and Their Biological Activity

Pukhov

Клочков

Afanasyeva

2021

JCPRM

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Sesquiterpene lactones (SL) are widely distributed in nature (formed biosynthetically in plants from farnesyl pyrophosphate) and are a structurally diverse class of terpenoids with 15 carbon atoms in the skeleton and, in addition to the lactone cycle, can contain various functional groups. Some of them exhibit biological activity both in a rather wide range and in relation to a specific target. An increase in the number of undescribed natural plant compounds of this class, as well as detection in various plant species, opens up new possibilities for their use for the purposes of medical chemistry, phytochemistry, pharmacognosy, chemotaxonomy, and related fields. Using the example of SL of the eudesmane structural type found in plants of the genus Inula, this review attempts to show the relevance of studies of such compounds that investigate the mechanism of action on various biological models, including the goal of developing new effective antitumor agents.

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Section: Fig 2 Structures Of Isomeric Alantolactonesmentioning

confidence: 99%

“…10, lactones 60-62 lack an axial OH group at position 1. These compounds include the vicinal diol pulchellin C (60). It was first isolated from the plant Gaillardia pulchella Foug.…”

Section: Polyhydroxyl-containing α-Methylene-γ-lactonesmentioning

confidence: 99%