Biological Activity of Complex Ions

Dwyer, Francis Patrick John; Gyarfas, E C; Rogers, W. P.; Koch, J. H.

doi:10.1038/170190a0

Cited by 263 publications

(277 citation statements)

References 9 publications

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“…It has .been found in earlier experiments (Dwyer et al 1952) that the injection of atropine prior to the complexes potentiated the toxic action of both isomers. It was postulated that atropine increases the permeability of certain tissues to small cations (Kirschner 1953).…”

Section: (D) the Effect Of Atropine On Lobru(phenls ++ Levels In Bloomentioning

confidence: 96%

“…The biological activity of certain inorganic coordination complexes has been the subject of previous communications (Dwyer et al 1952;Koch et al 1956). The complex cations investigated were coordinately saturated and of high chemical stability and did not contain any specific active groups or centres.…”

Section: Introductionmentioning

confidence: 99%

“…The complex cations investigated were coordinately saturated and of high chemical stability and did not contain any specific active groups or centres. Experiments on enzyme systems (Dwyer et al 1952;Koch et al 1956), rat diaphragm and frog sartorius preparations (Shulman, unpublished data), and estimation of their toxicity to mice after intraperitoneal administration (Koch et al 1956) showed that they are potent inhibitors of acetylcholinesterase and possess curare-like activity. The anticholinesterase activity and the toxic action of series of metal complexes of phenanthroline, bipyridine, and terpyridine have been investigated in detail.…”

Section: Introductionmentioning

confidence: 99%

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The Metabolic Fate of Tris-1,10-Phenanthroline 106Ruthenium (II) Perchlorate, a Compound With Anticholinesterase and Curare-Like Activity

Koch¹,

Rogers²,

Dwyer³

et al. 1957

Aust. Jnl. Of Bio. Sci.

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SummaryTris-l,IO-phenanthroline ruthenium(II) perchlorate is a representative of a group of stable inorganic complex compounds with anticholinesterase and curarelike activities.The labelled ruthenium complex has been prepared and resolved into its optical antipodes. The metabolic fate of the stereoisomers and the racemate was investigated.The complex administered intraperitoneally was not metabolized by the tissues of mice and rats. It was excreted mainly in the urine. No traces of it could be found in nervous tissues, It accumulated appreciably in kidney and liver but the amounts found in other tissues were below that in blood.After intraperitoneal administration the (+) and (±) forms of the complex appeared at a greater rate in blood and urine than the (-) form.Atropine, which 'has been found to enhance the toxicity of the complex, raised the rate of appearance of the (-) form in blood and urine but had little effect on the passage of the (+) isomer.

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Section: (D) the Effect Of Atropine On Lobru(phenls ++ Levels In Bloomentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Metabolic Fate of Tris-1,10-Phenanthroline 106Ruthenium (II) Perchlorate, a Compound With Anticholinesterase and Curare-Like Activity

Koch¹,

Rogers²,

Dwyer³

et al. 1957

Aust. Jnl. Of Bio. Sci.

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“…(NAMI-A) and sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) are currently undergoing clinical trials with promising results [1][2][3]; however, antitumor properties of Ru complexes were already reported in the 1950s [4]. In the last decade, numerous organometallic ruthenium(II)- 6 -arene complexes mainly with piano-stool structure were synthesized and tested in in vitro assays regarding their bioactivity.…”

Section: The Two Ru(iii) Complexes Imidazolium Trans-[tetrachlorido(dmentioning

confidence: 99%

Solution equilibria of anticancer ruthenium(II)-(η6-p-cymene)-hydroxy(thio)pyr(id)one complexes: Impact of sulfur vs. oxygen donor systems on the speciation and bioactivity

Enyedy

Sija

Jakusch

et al. 2013

Journal of Inorganic Biochemistry

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“…Early work by the group of Dwyer demonstrated that coordination complexes of Ru(II), Ni(II), Cu(II), Fe(II) or Co(II) with ligands such as 1,10-phenanthroline or 2,2'-bipyridine have activity against both Gram-positive and Gram-negative bacteria [12,13]. As recently reviewed by us, these complexes interact with DNA through intercalation [14].…”

Section: Introductionmentioning

confidence: 99%

The antimicrobial and antibiofilm activities of copper(II) complexes

Beeton

Aldrich‐Wright

Bolhuis

2014

Journal of Inorganic Biochemistry

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Gram-positive and Gram-negative bacteria, albeit that activity was generally higher for the former. The antibiofilm activity was then determined against a clinical isolate of meticillin-resistant Staphylococcus aureus (MRSA). Strikingly, the copper complexes tested showed significant activity against biofilms, and were better in the removal of biofilms than vancomycin, an antibiotic that is currently used in the treatment of MRSA infections.

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Biological Activity of Complex Ions

Cited by 263 publications

References 9 publications

The Metabolic Fate of Tris-1,10-Phenanthroline 106Ruthenium (II) Perchlorate, a Compound With Anticholinesterase and Curare-Like Activity

The Metabolic Fate of Tris-1,10-Phenanthroline 106Ruthenium (II) Perchlorate, a Compound With Anticholinesterase and Curare-Like Activity

Solution equilibria of anticancer ruthenium(II)-(η6-p-cymene)-hydroxy(thio)pyr(id)one complexes: Impact of sulfur vs. oxygen donor systems on the speciation and bioactivity

The antimicrobial and antibiofilm activities of copper(II) complexes

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