Biological Activity of Crude Extract and Saponin Pseudoginsenoside-RT1 Derived from the Fruit of Randia siamensis

Cardiovascular Effects of an n-Butanol Extract from Fresh Fruits of Randia siamensis

“…These results differ from our previous report on the effect of the pseudoginsenoside-RT 1 on blood pressure and heart rate, when it was found that the pseudoginsenoside-RT 1 caused a decrease in the mean arterial blood pressure with an increase in heart rate in a dose-dependent manner 6) similar to those produced by isoproterenol, a non-specific b-adrenergic receptor agonist. Whereas in the present study it was found that the R. siamensis extract caused an increase in both MAP and heart rate similar to that of adrenaline, whereas the hypotensive activity was found only when the rats were pretreated with phentolamine or phentolamine plus propranolol.…”

“…However, the activity of the purified compound was much less potent than that of the crude extract. Jansakul et al 6) tested the activities of the pseudoginsenoside-RT 1 , isolated by Aukkanibutra, 4) on the cardiovascular system and found that the pseudogensenoside-RT 1 (4-32 mg/kg) caused a decrease in mean arterial blood pressure, with an increased heart rate in a dose-dependent manner in anesthetized rats. However, the mechanisms for these effects have not yet been elucidated due to the limited availability of the substance.…”

An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis

“…During the course of this study, limonoids were identified as Phe508del-CFTR correctors. In previous studies with the extract from another medicinal plant, Randia siamensis, we also found effects on ion transport properties in mouse trachea (Jansakul et al, 1999). Extracts from R. siamensis induced Cl Ϫ secretion by activation of Ca 2ϩ -dependent Cl Ϫ channels.…”

“…The n-butanol phase was collected and evaporated in vacuo and lyophilized. The extract was further purified by column chromatography as described previously (Jansakul et al, 1999). Identification was made by Prof. P. Sirirugsa (Department of Biology, Faculty of Science, Prince of Songkla University) and Prof. K. Hostettmann (Laboratoire de Pharmacognosie et Phytochimie, Ecole de Pharmacie, Universite de Geneve, Geneve, Switzerland).…”

Saponins from Fresh Fruits of Randia siamensis (Lour) Roem. & Schult. (Rubiaceae)

“…The authors also found that pseudoginsenoside-RP 1 might partly contribute to the anti-nociceptive action of the extract [4]. Studies on rats showed that pseudoginsenoside RT 1 decreased blood pressure, increased heart rate and increased spontaneous contractility of the uterus [5].…”