Biological activity of electrochemically synthesized silver doped polyvinyl alcohol/graphene composite hydrogel discs for biomedical applications

Abudabbus, Mohamed M.; Jevremović, Ivana; Janković, Ana; Perić-Grujić, Aleksandra A.; Matić, Ivana Z.; Vukašinović-Sekulić, Maja; Hui, David; Rhee, Kyong Yop; Mišković‐Stanković, Vesna

doi:10.1016/j.compositesb.2016.08.024

Cited by 51 publications

(55 citation statements)

References 51 publications

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“…[24] In brief, an aqueous solution of the PVA (10 wt%) was prepared by dissolving the PVA powder in hot dH2O (90 °C …”

Section: Electrochemical Synthesis Of Composite Hydrogelmentioning

confidence: 99%

“…[24] In brief, the experimental procedure involved seeding PBMC suspension in a 24-well plate in nutrient medium. Control was cell suspension without biomaterial samples.…”

Section: Cytotoxicity Peripheral Blood Mononuclear Cells (Pbmcs)mentioning

confidence: 99%

“…[24] The number of viable colonies (CFU mL −1 ) of S. aureus and E. coli was determined using a colony counter at the start of the experiment and after incubation at 37 °C for up to 24 h.…”

Section: Cytotoxicity Peripheral Blood Mononuclear Cells (Pbmcs)mentioning

confidence: 99%

“…The effect of polymer matrix on stabilization of nanoparticles and hindering the undesired deposition of a silver layer at the cathode surface has been explained elsewhere. [24,36] Namely, -OH groups of PVA chain interact with Ag + , allowing for the formation of Agm m+ -PVA complex, which undergoes electrochemical reduction at the cathode surface. Resulting Agm 0 -PVA complex is then stabilized by PVA chains.…”

Section: Preparation Of Pva/gr Hydrogelsmentioning

confidence: 99%

“…[23] This was also confirmed for PVA/Gr and Ag/PVA/Gr nanocomposites in our previous work. [21,24,25] Additionally, several studies indicated that graphene possesses a certain degree of antibacterial activity, with the ability to induce membrane rupture and oxidative stress of bacterial cells. [26,27] This could be an important property, especially in the initial period of Ag/PVA/Gr wound dressing application, when Gr presence could enhance the antibacterial properties of AgNPs and help prevent wound infection and biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

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Graphene Based Composite Hydrogel for Biomedical Applications

Nešović¹,

Abudabbus²,

Rhee³

et al. 2017

Croat. Chem. Acta

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In this work, composite hydrogel consisting of poly(vinyl alcohol), graphene and silver nanoparticles, (Ag/PVA/Gr), was prepared by the immobilization of silver nanoparticles (AgNPs) in PVA/Gr hydrogel matrix in two steps. The first step was cross linking of the PVA/Gr colloid solution by the freezing/thawing method, while in the second step, in situ electrochemical method was used to incorporate AgNPs inside the PVA/Gr hydrogel matrix. We used UV-vis spectroscopy, cyclic voltammetry, Raman spectroscopy, DSC analysis, as well as test of cytotoxicity and antibacterial activity, to characterize obtained Ag/PVA/Gr hydrogel. It was shown that graphene-based composite hydrogel with incorporated AgNPs is non toxic biomaterial with antibacterial activity, with a potential for use in biomedical purposes.

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“…[24] In brief, an aqueous solution of the PVA (10 wt%) was prepared by dissolving the PVA powder in hot dH2O (90 °C …”

Section: Electrochemical Synthesis Of Composite Hydrogelmentioning

confidence: 99%

“…[24] In brief, the experimental procedure involved seeding PBMC suspension in a 24-well plate in nutrient medium. Control was cell suspension without biomaterial samples.…”

Section: Cytotoxicity Peripheral Blood Mononuclear Cells (Pbmcs)mentioning

confidence: 99%

Section: Cytotoxicity Peripheral Blood Mononuclear Cells (Pbmcs)mentioning

confidence: 99%

Section: Preparation Of Pva/gr Hydrogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Graphene Based Composite Hydrogel for Biomedical Applications

Nešović¹,

Abudabbus²,

Rhee³

et al. 2017

Croat. Chem. Acta

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Comparative analysis of PVA hydrogels incorporating two natural antimicrobials: Punica granatum and Arnica montana tinctures

Oliveira

Paranhos

Moreira

et al. 2017

J of Applied Polymer Sci

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Poly(vinyl alcohol) (PVA) hydrogels are biocompatible materials that retain relatively high amounts of aqueous fluids in their network. The incorporation of antimicrobial natural products, such as pomegranate and arnica, is a strategy for coupling their bactericidal effects with the favorable properties of the gels for wound healing treatment. The goal of this work was to investigate the microstructural, mechanical, and release properties of PVA-pomegranate and PVA-arnica samples. Physical interactions were observed by Fourier transform infrared spectra in PVA-pomegranate samples. The addition of pomegranate to PVA led to high T g , probably related to the physical interactions, and low T m and X c , possibly due to the pomegranate location between PVA chains. Increased levels of arnica were associated with a slight decrease in samples' X c , probably due to a physical barrier imposed by arnica to the interaction of PVA chains. PVA samples presented higher swelling than the samples containing natural products. High amounts of pomegranate in the samples led to high weight loss and high phenols and flavonoids delivery. Arnica release seemed to be more difficult than the pomegranate release. All samples presented relative high mechanical properties. In addition, pomegranate samples present higher potential to deliver active compounds than arnica samples.

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Antibacterial efficacy of poly (vinyl alcohol) nanocomposites reinforced with graphene oxide and silver nanoparticles for packaging applications

Gautam

Sharma

et al. 2021

Polymer Composites

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Antibiotic resistance is a major threat to public health and food security. Attributable to the heightening occurrence and proliferation of antibiotic‐resistant pathogenic microorganisms, the development of antimicrobial packaging has emerged as a promising technology. Poly (vinyl alcohol) (PVA), a water‐soluble synthetic polymer is contemplated as a promising biocompatible, biodegradable, and low cytotoxic material for various medical, industrial, and commercial applications. To stretch its applications, the polymer material was doped with graphene oxide (GO) decorated with silver nanoparticles (Ag). In this study, an eco‐friendly, facile, one‐step chemical reduction route was employed for the synthesis of nanocomposites by an Ag nanoparticle anchored on GO nanoparticle. The polymer nanocomposite thin film was prepared by solution casting technique. Homogeneity of dispersion and surface morphology was examined by scanning electron microscope investigation. The inclusion of GO‐Ag nanocomposite in the polymer matrix increases the roughness of the film confirmed by atomic force microscopy analysis. The increment in properties was attributable to excellent H bonding between PVA and GO wherein molecules are strongly intercalated with each other. The tensile strength, as well as thermal stability of the PVA/GO/Ag thin films, was significantly enhanced on the incorporation of GO/Ag nanoparticles confirmed by TGA analysis. PVA/GO/Ag nanocomposites exhibited effective antibacterial activity against gram‐positive bacteria Staphylococcus aureus and gram‐negative bacteria Escherichia coli. In contrast, no inhibition around pristine PVA was observed. The prepared films proffered an effective antibacterial activity against contagious microorganisms that qualify them for food packaging and different biomedical applications.

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Biological activity of electrochemically synthesized silver doped polyvinyl alcohol/graphene composite hydrogel discs for biomedical applications

Cited by 51 publications

References 51 publications

Graphene Based Composite Hydrogel for Biomedical Applications

Graphene Based Composite Hydrogel for Biomedical Applications

Comparative analysis of PVA hydrogels incorporating two natural antimicrobials: Punica granatum and Arnica montana tinctures

Antibacterial efficacy of poly (vinyl alcohol) nanocomposites reinforced with graphene oxide and silver nanoparticles for packaging applications

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