Biological activity of Entada phaseoloides and Entada rheedei

Sugimoto, Sachiko; Matsunami, Katsuyoshi; Otsuka, Hideaki

doi:10.1007/s11418-017-1146-x

Cited by 9 publications

(8 citation statements)

References 36 publications

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“…In the previous reports, many active compounds have been isolated from E. phaseoloides seeds and stems such as quercetin, luteolin, apigenin, and kaempferol. 6 To propose the active compounds in AEP, its profile was analyzed by HPLC.…”

Section: Resultsmentioning

confidence: 99%

“…The seeds of Entada species are utilized as a folk medicine to treat skin disease and as a soap in Indonesia, Thailand, and other tropical countries. 5,6 However, the biological activities of the leaves of E. phaseoloides are barely mentioned. To reduce intracellular ROS levels could be a good way to avoid UVB-induced human epidermal keratinocytes (HaCaT cells) apoptosis and skin damage.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Protective Effect of Acetone Extract of Entada phaseoloides Leaves on UVB-Irradiated Human Epidermal Keratinocytes (HaCaT cells) by Inhibiting COX-2, iNOS, and Caspase-3 Activation

Mittraphab

Matsumoto

Shimizu

2022

Natural Product Communications

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Chronic ultraviolet (UV) exposure produces oxidative stress, molecular damage, and aging-related signal transduction, all of which contribute to skin photoaging. In this study, the antioxidant and anti-inflammatory activities of Entada phaseoloides are reported. High-performance liquid chromatography (HPLC) detected 7 phenolic compounds: gallic acid, protocatechuic acid, 4-hydroxybenzoic acid, quercetin, luteolin, kaempferol, and apigenin. We investigated the antioxidant and protective effect of the acetone extract of E. phaseoloides leaves (AEP) on UVB-irradiated human epidermal keratinocytes (HaCaT cells). AEP showed antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays. AEP at a concentration of 40 μg/mL increased cell survival rate of the UVB-damaged cells. Moreover, AEP blocked gene expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in UVB-induced HaCaT cells and decreased UVB-induced apoptosis in HaCaT cells by regulating the gene expression of caspase-3. These results suggest that AEP has the potential to protect against UVB irradiation and antioxidant.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant and Protective Effect of Acetone Extract of Entada phaseoloides Leaves on UVB-Irradiated Human Epidermal Keratinocytes (HaCaT cells) by Inhibiting COX-2, iNOS, and Caspase-3 Activation

Mittraphab

Matsumoto

Shimizu

2022

Natural Product Communications

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“…Entadamide A showed potential anti melanin inhibition with activity similar to arbutin, a common cosmetic ingredient (Sugimoto et al 2018). Therefore, entadamide A could be responsible for inhibiting tyrosinase as a solute in the ethanol solvent.…”

Section: Anti-tyrosinase Activitymentioning

confidence: 99%

Phenolic Content and Biological Activities of Ethanol Extracts from Medicinal Plants in East Kalimantan, Indonesia

Mariani¹,

Tammachote²,

Kusuma³

et al. 2021

JSM

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The Dayak tribe are the indigenous people of West Kutai, East Kalimantan, Indonesia, and they have experiences in using plants for traditional medicine and the commonly used plants include Baccaurea macrocarpa (Miq.) Müll.Arg., Entada phaseoloides (L.) Merr., Goniothalamus macrophyllus (Blume) Hook.f. & Thomson, Gynura crepidioides Benth., Helicia robusta (Roxb.) R. Br var. robusta, Litsea elliptica, Pogostemon cablin (Blanco) Benth, and Rhodomyrtus tomentosa (Aiton) Hassk. Therefore, the present study aimed to analyze these plant species for their phenolic content, and antioxidant, antibacterial, anti-tyrosinase, and anticancer activities. The total phenolic content and total antioxidant capacity were analyzed using Folin-Ciocalteu reagent and the phosphomolybdenum method, respectively. The antioxidant activities were evaluated by DPPH and ABTS assays. The antibacterial activity was determined by agar well diffusion and microdilution methods against six bacterial strains. The anticancer activity of the plant extracts was assayed against MDA-MB-231 human breast cancer cells. Based on the ethanol extraction, the highest yield was obtained from L. elliptica (10.42%), while H. robusta extract contained the highest phenolic content, antioxidant capacity, and antioxidant activities. All the extracts exhibited antibacterial activities against all the tested strains of bacteria, with the highest activity found in R. tomentosa extract, which also showed the highest activity against the cancer cells. The ethanol extract from E. phaseoloides exhibited tyrosinase inhibition activity (IC50 = 543.83 ± 51.06 µg/mL). The results herein suggested that the ethanol extracts from some medicinal plants from East Kalimantan have potential as antioxidant, antibacterial, anticancer, and anti-tyrosinase agents.

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“…By altering TGF-signalling, lowering MMP-1 and MMP-2 expression, and reducing the synthesis of type I collagen in human dermal fibroblasts, EGCG inhibits TGF- receptors. These characteristics suggested that EGCG may have anti-scarring capabilities [ 100 ].…”

Section: Wound Healing Strategiesmentioning

confidence: 99%

Local Drug Delivery Strategies towards Wound Healing

Tiwari

Pathak

2023

Pharmaceutics

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A particular biological process known as wound healing is connected to the overall phenomena of growth and tissue regeneration. Several cellular and matrix elements work together to restore the integrity of injured tissue. The goal of the present review paper focused on the physiology of wound healing, medications used to treat wound healing, and local drug delivery systems for possible skin wound therapy. The capacity of the skin to heal a wound is the result of a highly intricate process that involves several different processes, such as vascular response, blood coagulation, fibrin network creation, re-epithelialisation, collagen maturation, and connective tissue remodelling. Wound healing may be controlled with topical antiseptics, topical antibiotics, herbal remedies, and cellular initiators. In order to effectively eradicate infections and shorten the healing process, contemporary antimicrobial treatments that include antibiotics or antiseptics must be investigated. A variety of delivery systems were described, including innovative delivery systems, hydrogels, microspheres, gold and silver nanoparticles, vesicles, emulsifying systems, nanofibres, artificial dressings, three-dimensional printed skin replacements, dendrimers and carbon nanotubes. It may be inferred that enhanced local delivery methods might be used to provide wound healing agents for faster healing of skin wounds.

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Biological activity of Entada phaseoloides and Entada rheedei

Cited by 9 publications

References 36 publications

Antioxidant and Protective Effect of Acetone Extract of Entada phaseoloides Leaves on UVB-Irradiated Human Epidermal Keratinocytes (HaCaT cells) by Inhibiting COX-2, iNOS, and Caspase-3 Activation

Antioxidant and Protective Effect of Acetone Extract of Entada phaseoloides Leaves on UVB-Irradiated Human Epidermal Keratinocytes (HaCaT cells) by Inhibiting COX-2, iNOS, and Caspase-3 Activation

Phenolic Content and Biological Activities of Ethanol Extracts from Medicinal Plants in East Kalimantan, Indonesia

Local Drug Delivery Strategies towards Wound Healing

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