Biological Activity of Natural and Synthetic Compounds

Granchi, Carlotta

doi:10.3390/molecules27123652

Molecules

2022

DOI: 10.3390/molecules27123652

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Biological Activity of Natural and Synthetic Compounds

Carlotta Granchi

Abstract: A drug discovery program starts when a disease or clinical condition has no suitable drugs [...]

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2024

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Cited by 2 publications

References 15 publications

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Harnessing Natural Quorum Sensing Inhibitors to Prevent Porphyromonas gingivalis-Induced Oral Squamous Cell Carcinoma: An Innovative Approach

Naseef Pathoor,

Sankar Ganesh

2024

Galician med. j.

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The quest for effective cancer preventive strategies has led researchers to explore novel ways that go beyond conventional treatments. One such innovative method involves using natural quorum sensing inhibitory compounds to target Porphyromonas gingivalis, a periodontal pathogen that plays a major role in the development of oral squamous cell carcinoma. This letter highlights recent research on natural quorum sensing inhibitors and their implications in prevention of oral squamous cell carcinoma, aiming to shift the focus from treatment to prevention. Efficacy assessment and mechanistic insights are discussed to emphasize the significance of this approach.

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Harnessing Natural Quorum Sensing Inhibitors to Prevent Porphyromonas gingivalis-Induced Oral Squamous Cell Carcinoma: An Innovative Approach

Naseef Pathoor,

Sankar Ganesh

2024

Galician med. j.

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Exosomes as Novel Delivery Systems for Application in Traditional Chinese Medicine

Chen

Wang

et al. 2022

Molecules

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Exosomes, as gifts of nature derived from various cell types with a size range from ~40 to 160 nm in diameter, have gained attention recently. They are composed of a lipid membrane bilayer structure containing different constituents, such as surface ligands and receptors, from the parental cells. Originating from a variety of sources, exosomes have the ability to participate in a diverse range of biological processes, including the regulation of cellular communication. On account of their ideal native structure and characteristics, exosomes are taken into account as drug delivery systems (DDSs). They can provide profound effects on conveying therapeutic agents with great advantages, including specific targeting, high biocompatibility, and non-toxicity. Further, they can also be considered to ameliorate natural compounds, the main constituents of traditional Chinese medicine (TCM), which are usually ignored due to the complexity of their structures, poor stability, and unclear mechanisms of action. This review summarizes the classification of exosomes as well as the research progress on exosome-based DDSs for the treatment of different diseases in TCM. Furthermore, this review discusses the advantages and challenges faced by exosomes to contribute to their further investigation and application.

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Biological Activity of Natural and Synthetic Compounds

Abstract: A drug discovery program starts when a disease or clinical condition has no suitable drugs [...]

Cited by 2 publications

References 15 publications

Harnessing Natural Quorum Sensing Inhibitors to Prevent Porphyromonas gingivalis-Induced Oral Squamous Cell Carcinoma: An Innovative Approach

Harnessing Natural Quorum Sensing Inhibitors to Prevent Porphyromonas gingivalis-Induced Oral Squamous Cell Carcinoma: An Innovative Approach

Exosomes as Novel Delivery Systems for Application in Traditional Chinese Medicine

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