Biological Activity of Naturally Derived Naphthyridines

Abstract

Marine and terrestrial environments are rich sources of various bioactive substances, which have been used by humans since prehistoric times. Nowadays, due to advances in chemical sciences, new substances are still discovered, and their chemical structures and biological properties are constantly explored. Drugs obtained from natural sources are used commonly in medicine, particularly in cancer and infectious diseases treatment. Naphthyridines, isolated mainly from marine organisms and terrestrial plants, represent prominent examples of naturally derived agents. They are a class of heterocyclic compounds containing a fused system of two pyridine rings, possessing six isomers depending on the nitrogen atom’s location. In this review, biological activity of naphthyridines obtained from various natural sources was summarized. According to previous studies, the naphthyridine alkaloids displayed multiple activities, i.a., antiinfectious, anticancer, neurological, psychotropic, affecting cardiovascular system, and immune response. Their wide range of activity makes them a fascinating object of research with prospects for use in therapeutic purposes.

Systematic Review on Thiazole Compounds as Nanoparticles: Chemistry, Synthesis, Antimicrobial Activities, Therapeutic Investigation

“…Among the target compounds, imidazol derivative, 1-[ (2-(4-chlorophenyl) thiazol-4-yl) methyl]-1Himidazole and triazolyl derivative, 1-[ (2-phenylthiazol-4-yl)methyl]-1H-1,2,4-triazole and its 4-chlorophenyl analog showed the highest anticonvulsant activity in both models with percentage protection range of 33-100%. The structure-activity relationship and druglikeness studies revealed that thiazole-incorporated (arylalkyl)azoles which showed good protection in both models of epilepsy (PTZ and MES) can be regarded as promising candidate for future investigations [113,114]: (12). Structure of some thiazole derivatives with anticonvulsant activity.…”

“…As one of basic five-membered heterocycles, the thiazole substructure is widely found in many bioactive natural products including the cytology compound thiazole [6][7][8][9]. On the other hand, the thiazole ring is present in various marine or terrestrial natural compounds that have useful biological activities [10][11][12][13]. In the recent years, experimental researches have introduced some thiazole derivatives as the multitherapeutic effect compounds including anticancer, anti-inflammatory, and inhibitor of the parasites like Leishmania and the fungi such as Candida [14][15][16][17].…”

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

“…Aaptamines, 75 are a group of bioactive benzo[de[1,6]]-naphthyridine alkaloids, isolated from marine sponges mostly belonging to the genus Aaptos [ 95 ]. Aaptamine, 75 , possesses antioxidative, antimicrobial, antifungal, and antiretroviral activity.…”

Silver Catalyzed Cascade Strategy for the Synthesis of Diversely Substituted Polycyclic Fused 1,7‐Naphthyridine Scaffolds

“…[2] Moreover, these scaffolds are also found in a number of natural products such as Canthin-6-one, Cimiciduphytine, Jasminine, Aaptamine, Suberitines, and Bisleuconothine as shown in Figure 1(a). [3] Fused naphthyridine skeletons are particularly active as Tpl2 kinase inhibitors, [4] NK1 antagonists, [5] anticancer, [6] PIP4K2A inhibitors as shown in Figure 1(b). [7] Their fused adducts can be found in natural products like indolo [1,7]naphthyridine alkaloids ex-tracted from Incarvillea mairei var.…”

“…In addition, their synthetic derivatives have various biological activities, such as antioxidative, antimalarial, anticonvulsant, antihypertensive, platelet inhibition, antiallergic, antihypertensive, pesticide, and antagonist activities [2] . Moreover, these scaffolds are also found in a number of natural products such as Canthin‐6‐one, Cimiciduphytine, Jasminine, Aaptamine, Suberitines, and Bisleuconothine as shown in Figure 1(a) [3] . Fused naphthyridine skeletons are particularly active as Tpl2 kinase inhibitors, [4] NK1 antagonists, [5] anticancer, [6] PIP4K2A inhibitors as shown in Figure 1(b) [7] .…”