Biological Activity of Organogermanium Compounds

Lukevics, É.; Игнатович, Л.

doi:10.1002/9780470682531.pat0275

Cited by 6 publications

(2 citation statements)

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“…Most likely, no bonds with such groups were formed in the case of C. albidus, hence most of the compounds were inactive towards it. The data presented differ from the previously reported results on citrate-germanate complexes as α-L-rhamnosidase modifiers [16] and indicate the essential role of the composition of complex germanium-containing anion, as the complex cations were the same.…”

Section: Resultscontrasting

confidence: 99%

“…As α-L-rhamnosidase modifiers , coordination compounds of germanium, an essential ultratrace element, with various biologically active ligands have received increasing interest recently [10][11][12]. Due to the peculiarities of electronic configuration, germanium is able to promote tissue oxygenation, enhance blood circulation, strengthen the immune system, promote γ-interferon induction, normalize metabolism, and exhibit antitumor effect [13][14][15][16]. A lack of germanium can cause pathological conditions linked to reducing in immunity.…”

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The influence of coordinative tartrate and malatogermanate compounds on the activity of ?-L-rhamnosidase preparations from Penicillium tardum, Eupenicillium erubescens and Cryptococcus albidus

Гудзенко¹,

Varbanets²,

Сейфулліна³

et al. 2020

Ukr.Biochem.J

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recently enzyme preparations of microbial origin become increasingly important in different industries. Preparations of α-L-rhamnosidase are used in the pharmaceutical industry as well as in scientific work as a tool for analytical research. We have obtained purified α-L-rhamnosidase preparations from Penicillium tardum, eupenicillium erubescens and Cryptococcus albidus microorganism strains which are effective enzyme producers. the aim of the study was to estimate the ability of germanium coordination compounds to enhance enzyme catalytic activity. the effects of 11 heterometal mixed ligand tartrate (malate-)germanate compounds at 0.01 and 0.1% concentration on the activity of α-L-rhamnosidase preparations from Penicillium tardum IMV f-100074, eupenicillium erubescens and Cryptococcus albidus 1001 were studied at 0.5 and 24 h exposition. the inhibitory effect of [ni(bipy) 3 ] 4 [{Ge 2 (oh) 2 (tart) 2 } 3 Cl 2 ]•15h 2 on P. tardum α-L-rhamnosidase was revealed. all studied compounds except [CuCl(phen) 2 ][Ge(oh)(hMal) 2 ] were shown to increase activity of P. tardum α-L-rhamnosidase at a longer term of exposition. activity of e. erubescens α-L-rhamnosidase was shown to be stimulated by d-metal cation-free compounds. C. albidus α-L-rhamnosidase occurred to be insensitive to all compounds studied.

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confidence: 99%

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confidence: 99%