Biological activity of quaternary ammonium salts and resistance of microorganisms to these compounds

Obłąk, Ewa; Futoma-Kołoch, Bożena; Wieczynska, Anna

doi:10.1007/s11274-020-02978-0

Cited by 48 publications

(23 citation statements)

References 109 publications

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“…As for the individual components AC2AC6N and H-MMA-C10, they did not exhibit significant bactericidal activity and cytotoxicity even at 200 μM (Figures S4 and S5). In general, ammonia or ammoniums with long hydrophobic chains are toxic, as ammonia can permeate cell membranes and ammoniums with hydrophobic chains can disrupt cell membranes, while AC2AC6N does not contain long hydrophobic chains. − Negatively charged surfactants are also generally considered nontoxic at low concentrations. Therefore, the safety of H-AMC-10 is guaranteed.…”

Section: Resultsmentioning

confidence: 99%

Degradable Bactericide Constructed Using a Charge-Reversal Surfactant against Plant Pathogenic Bacteria

Zeng

Zhang

2022

ACS Appl. Mater. Interfaces

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Plant bacterial diseases are serious problems in agriculture, posing threats to global food security and the agricultural economy. Here, a degradable agricultural bactericide AMC-10 constructed using a charge-reversal surfactant, from being positively charged to negatively charged, was designed and synthesized. AMC-10 possessed high bactericidal activity toward plant pathogenic bacteria, consequently being able to inhibit the corresponding plant bacterial diseases. After degradation by water, the hydrolyzed products were nontoxic to bacteria and human cells. Such a degradable bactericide provides new ideas for the design of environmentally friendly agricultural bactericides. It is anticipated that degradable bactericides such as AMC-10 can be applied in the prevention and control of plant bacterial diseases, being less likely to produce toxicity or drug resistance.

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Section: Resultsmentioning

confidence: 99%

Degradable Bactericide Constructed Using a Charge-Reversal Surfactant against Plant Pathogenic Bacteria

Zeng

Zhang

2022

ACS Appl. Mater. Interfaces

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“…The cationic surfactants were once supposed to be impervious to resistance. However, after huge accumulation in the environment over the past decades, bacteria have acquired surfactant resistance [ 67 , 68 , 69 ]. Moreover, it is a great challenge to design highly antibacterial surfactants with high selectivity, as the essential factors for antibacterial activity also predominate their cytotoxicity.…”

Section: Supramolecular Self-assembly Of Cationic Surfactants and Pol...mentioning

confidence: 99%

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Guo

Yuan-yuan

et al. 2022

Pharmaceuticals

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Antibiotic resistance has posed a great threat to human health. The emergence of antibiotic resistance has always outpaced the development of new antibiotics, and the investment in the development of new antibiotics is diminishing. Supramolecular self-assembly of the conventional antibacterial agents has been proved to be a promising and versatile strategy to tackle the serious problem of antibiotic resistance. In this review, the recent development of antibacterial agents based on supramolecular self-assembly strategies will be introduced.

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“…Due to this structure, QACs are able to effectively concentrate on the surface or at the interface, significantly reducing the surface tension [ 13 ]. The same feature of the QAC structure is also responsible for their antimicrobial effects [ 14 , 15 , 16 ]. These substances are biocidal against a number of microorganisms, including fungi, Gram-negative and Gram-positive bacteria, and lipophilic viruses [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Didecyldimethylammonium Chloride- and Polyhexamethylene Guanidine-Resistant Bacteria Isolated from Fecal Sludge and Their Potential Use in Biological Products for the Detoxification of Biocide-Contaminated Wastewater Prior to Conventional Biological Treatment

Лойко

Kanunnikov²,

Serdyukov

et al. 2022

Biology

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Toxic shock caused by the discharge of biocide-contaminated fecal sludge (FS) from chemical toilets to conventional wastewater treatment plants (WWTP) can be a major problem in activated sludge operation. It is necessary to develop new environmental approaches to mitigate the toxicity of biocides in order to avoid degrading the performance of WWTP. “Latrina”, a chemical toilet additive containing didecyldimethylammonium chloride and polyhexamethylene guanidine, is widely used in environmentally safe toilet complexes (ESTC) on Russian railway trains to deodorize FS and control microbial activity. In this work, seven biocide-resistant bacterial strains were isolated and identified from the FS of ESTC. The values of the minimum inhibitory and bactericidal concentrations of biocides for the isolated strains were 4.5–10 times higher than for the collection microorganisms. The bacterium Alcaligenes faecalis DOS7 was found to be particularly resistant to “Latrina”, the minimum inhibitory concentration of which was almost 30 times higher than recommended for ESTC. Biological products based on isolated bacterial strains proved to be effective for FS biodegradation under both aerobic and anaerobic conditions. The results of the biochemical oxygen demand test and the newly developed disk-diffusion bioassay confirmed that isolated strains contribute to reducing toxicity of biocidal agents in FS. Hyper-resistance, non-pathogenicity, and potential plant growth-promoting ability make A. faecalis DOS7 promising for use in various biological products for wastewater treatment and bioremediation of soils contaminated with biocides, as well as in agriculture to increase plant productivity.

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Biological activity of quaternary ammonium salts and resistance of microorganisms to these compounds

Cited by 48 publications

References 109 publications

Degradable Bactericide Constructed Using a Charge-Reversal Surfactant against Plant Pathogenic Bacteria

Degradable Bactericide Constructed Using a Charge-Reversal Surfactant against Plant Pathogenic Bacteria

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Didecyldimethylammonium Chloride- and Polyhexamethylene Guanidine-Resistant Bacteria Isolated from Fecal Sludge and Their Potential Use in Biological Products for the Detoxification of Biocide-Contaminated Wastewater Prior to Conventional Biological Treatment

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