Biological activity of sophorolipids and their possible use as antiviral agents

Borsanyiova, Maria; Patil, Abhijit; Mukherji, Ruchira; Prabhune, Asmita; Bopegamage, Shubhada

doi:10.1007/s12223-015-0413-z

Cited by 83 publications

(48 citation statements)

References 32 publications

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“…; Borsanyiova et al . ). A study using natural SL mixtures with a variety of sugar head groups reported antimicrobial activity against a range of predominately Gram‐positive bacteria (Shah and Prabhune ).…”

Section: Antimicrobial and Antifungal Properties Of Biosurfactantsmentioning

confidence: 97%

“…Lactonic forms are more hydrophobic (Borsanyiova et al . ) and have been reported to have better biocide activities (Ito et al . ) as well as spermicide, cytotoxic and pro‐inflammatory activities.…”

Section: Classification and Structure Of Microbial Biosurfactants Of mentioning

confidence: 99%

“…These results were in accordance with previously reported antibacterial, antifungal and antiviral activity of biosurfactants (Gomaa ; Borsanyiova et al . ; Jemil et al . ).…”

Section: Antimicrobial and Antifungal Properties Of Biosurfactantsmentioning

confidence: 99%

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Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

et al. 2019

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Synthetic surfactants are becoming increasingly unpopular in many applications due to previously disregarded effects on biological systems and this has led to a new focus on replacing such products with biosurfactants that are biodegradable and produced from renewal resources. Microbially derived biosurfactants have been investigated in numerous studies in areas including: increasing feed digestibility in an agricultural context, improving seed protection and fertility, plant pathogen control, antimicrobial activity, antibiofilm activity, wound healing and dermatological care, improved oral cavity care, drug delivery systems and anticancer treatments. The development of the potential of biosurfactants has been hindered somewhat by the myriad of approaches taken in their investigations, the focus on pathogens as source species and the costs associated with large‐scale production. Here, we focus on various microbial sources of biosurfactants and the current trends in terms of agricultural and biomedical applications.

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Section: Antimicrobial and Antifungal Properties Of Biosurfactantsmentioning

confidence: 97%

Section: Classification and Structure Of Microbial Biosurfactants Of mentioning

confidence: 99%

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Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

et al. 2019

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“…Sophorolipids (SLs), produced by a number of yeasts such as Candida bombicola , are a class of naturally derived glycolipid compounds containing a hydrophilic moiety and a hydrophobic moiety (Borsanyiova et al, 2016). They are biodegradable, exhibit low-toxicity and are environmentally friendly.…”

Section: Introductionmentioning

confidence: 99%

Inactivation of Salmonella spp. and Listeria spp. by Palmitic, Stearic, and Oleic Acid Sophorolipids and Thiamine Dilauryl Sulfate

et al. 2016

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Food contaminated with human pathogens, such as Salmonella spp. and Listeria monocytogenes, frequently causes outbreaks of foodborne illness. Consumer concern over the use of synthesized antimicrobials to enhance microbial food safety has led to a search of natural alternatives. The objectives of this study were to evaluate the antimicrobial activity of various types of sophorolipids (SLs) and thiamine dilauryl sulfate (TDS) against pathogenic Salmonella spp. and Listeria spp. Both free and lactonic forms of SLs were synthesized from Candida bombicola using palmitic, stearic, and oleic acids as co-feedstocks. TDS and purified SLs were used to treat cocktails of Salmonella spp. and Listeria spp. Results showed that lactonic SLs had higher antimicrobial activity than the free-acid form, and Gram-positive Listeria spp. were more susceptible to SLs and TDS than Gram-negative Salmonella spp. Listeria populations were reduced from an initial concentration of 7.2 log CFU/mL to a non-detectible level within a 1 min treatment of 0.1% (w/v) lactonic SLs and TDS in the presence of 20% ethanol, which itself did not significantly reduce the populations. There were no significant differences in the antimicrobial efficacy among palmitic, stearic, and oleic acid-based SLs against Salmonella or Listeria spp. Ethanol was utilized to improve the antimicrobial activity of free-acid SLs against Gram-negative bacteria. In general, TDS was more effective than the SLs against Salmonella and Listeria spp. scanning electron microscopy and transmission electron microscopy images showed that SLs and TDS damaged Listeria cell membranes and resulted in cell lysis. Overall, our results demonstrated that SLs and TDS in the presence of ethanol can be used to inactivate foodborne pathogens, especially Gram-positive bacteria.

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“…16–18 SLs are also antiviral 19 and can modulate the severity of sepsis. 20 However, their potential for CNS applications has not yet been explored.…”

mentioning

confidence: 99%

Sophorolipid Butyl Ester Diacetate Does Not Affect Macrophage Polarization but Enhances Astrocytic Glial Fibrillary Acidic Protein Expression at Micromolar Concentrations in Vitro

Ziemba¹,

Gottipati

Totsingan³

et al. 2017

ACS Chem. Neurosci.

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Peritoneal macrophages (PMACs) and spinal cord astrocytes were exposed to varying concentrations of soluble sophorolipid butyl ester diacetate (SLBEDA) in vitro. Macrophages and astrocytes demonstrated no decrease in viability in response to SLBEDA. Studying pro-and antiinflammatory genes, PMACs did not show a shift toward a pro-inflammatory phenotype. However, at higher concentrations (3 and 30 μM), astrocytes showed an increase in their expression of glial acidic fibrillary protein. This novel category of compounds poses low risk to PMAC and astrocyte viability; however, the effect on PMAC polarization and astrocyte reactivity requires more elucidation. Graphical abstract Supporting InformationThe Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschemneuro.6b00451. Additional methods and results for SLBEDA synthesis and characterization and plasticity of PMAC polarization test (PDF) Notes Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. The authors declare no competing financial interest. (SCI). 1 The mechanical insult accompanying injury produces hemorrhaging, ischemia, and edema that result in an expanding lesion. 2 After approximately 2 h, the injury progresses to a secondary injury phase characterized by inflammation. Neutrophils first infiltrate the injury site followed by the activation of microglia and the recruitment of blood monocytes that differentiate and respond to the environment by polarizing to a pro-inflammatory or an antiinflammatory phenotype. M1, pro-inflammatory, macrophages are prevalent during the first several days postinjury 3 but persist weeks postinjury. 2,4 These macrophages produce high levels of reactive oxygen species (ROS) and pro-inflammatory cytokines. 3 Ultimately, this M1 macrophage pro-inflammation is neurotoxic and results in axonal dieback 3,4 and causes neuronal and glial necrosis. 5 In addition to macrophages, astrocytes also play an important role post-SCI. Astrocytes are a heterogeneous population of glial cells present in the central nervous system (CNS) and are primarily responsible for the overall maintenance of homeostasis in the CNS. 6 Following SCI, astrocytes at and around the site of the injury are activated, leading to the formation of a glial scar which acts as a chemical and physical barrier to regenerating axons. 7 The activation/reactivity of astrocytes is characterized by an increase in migration/proliferation 8,9 along with an increase in the production of the intermediate filament glial fibrillary acidic protein (GFAP) 10 and extracellular chondroitin sulfate proteoglycans (CSPGs). 11 GFAP synthesis is a meaningful aspect of the developmental plan of astrocyte differentiation, and it is a part of the reactive response to several CNS injuries. 12 After the injury, astrocytes show a decrease in GFAP until 1 day postinjury (dpi) followed by a steady increas...

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Biological activity of sophorolipids and their possible use as antiviral agents

Cited by 83 publications

References 32 publications

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

Inactivation of Salmonella spp. and Listeria spp. by Palmitic, Stearic, and Oleic Acid Sophorolipids and Thiamine Dilauryl Sulfate

Sophorolipid Butyl Ester Diacetate Does Not Affect Macrophage Polarization but Enhances Astrocytic Glial Fibrillary Acidic Protein Expression at Micromolar Concentrations in Vitro

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