Biological Activity of Thiazole Derivatives on Some Pathogenic Microorganisms

Abstract

The thiazole derivatives were prepared by the reaction of benzaldehyde derivatives with (2-thiooxamide-5-(p-bromobenzene)-1,3-thiazole) that was readily prepared by heating dithiooxamide with 4-bromophenacylbromide. Within invitro study the the effect of the prepared compounds on the growth of two types of fungi geotrichum cadidum and Trichophyton rubrum and the bacteria Escherichia coli, pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiella pneumoniae was evaluated. Incubation time and concentration were studied to find the optimal conditions for the activity. Compound II with the concentration 20 mg/ml found to be the most active compound toward geotrichum and Trichophyton rubrum. Statistical analysis of the values of colonial diameter shows low percentage error for the studied fungi with regard to incubation time.

Improving the sensory and rheological properties of yogurt using aqueous extract of basil (Ocimum basilicum L.)

“…This is consistent with Mohammed, [36] who studied the effectiveness of basil extract as an antidote to some pathogenic bacteria, including Escherichia coli and Staphylococcus aureus, and he found that higher concentrations show greater effectiveness on these bacteria compared to lower concentrations. This may be due to the nature of the main components present in the aqueous basil extract, the characteristics of these compounds, and the degree of their polarity [37].…”

Review of the synthesis and biological activity of thiazoles

“…[41] Hassan et al synthesized a group of thiazole derivatives (53, 57 and 58) and studied their biological properties (Scheme 18). [42] The thiazoles 61 were obtained by the acylation of thiosemicarbazide 60 reacted with a series of a-halogenocarbonyls 59a-f (Table 1) in acetone or DMF/acetone (Scheme 19). [43,44] Bueno et al used the Hantzsch method to construct the thiazole 65 (Scheme 20).…”