Biological agents and cell therapies in periodontal regeneration

Abstract

Regeneration of periodontal structures is a complex challenge for periodontal wound healing. As by Wikesjö et al. in this issue, wound space provision, primary stability, and healing by primary intention serve as critical factors for attempts to regenerate the periodontium. Barrier membranes for space maintenance can be cumbersome to use in a clinical setting and have proven to provide only partial success in regenerative therapies. Not surprisingly, investigators and clinicians have started to search for biological molecules and cell technologies that could help to either speed up or modify the healing process that depends on migration and differentiation of several different cell populations. In this chapter, we will briefly review the technologies that are currently in use or in clinical trials. Readers are welcome to review in‐depth publications for further details on this complex and evolving area of research.

Nanotechnology for Dentistry: Prospects and Applications

“…or modifying the healing process, which depends on the migration and differentiation of several different cell populations [152]. The primary therapy of choice is scaling and root planning SRP, often in combination with antimicrobial therapies and host modulation therapy [151].…”

“…The wound healing process is exposed to bacterial biofilms and mechanical forces. Plenty of growth factors and cytokines are involved in either speeding up or modifying the healing process, which depends on the migration and differentiation of several different cell populations [ 152 ]. The primary therapy of choice is scaling and root planning SRP, often in combination with antimicrobial therapies and host modulation therapy [ 151 ].…”