Biological Aging and Its Modification of Drug Activity

Pharmacodynamic Principles of Drug Therapy in the Aged*

“…Over the past ten years, evidence has accumulated which supports an already generally accepted view that the probability of experiencing adverse drug reactions increases with age (1, 2). During this same period, it has become increasingly appreciated that the activities of some drugs are modified in the geriatric patient and that these variations should be acknowledged in therapeutic regimens prescribed for patients in this age group (3)(4)(5)(6)(7)(8)(9)(10)(11).…”