Biological Aging: From the Boolean Networks, To the Geometric Phase

Barragán, Jorge; Sánchez, Silvia Barrientos

doi:10.19026/crjbs.7.5207

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…Bearing in mind that these are oscillatory systems (Tourigny, 2014;Cao et al, 2016), with an initially flat geometry parameter space (Carollo et al, 2003) and that such planarity is lost because it undergoes slow changes during puberty (Barragán and Sánchez, 2015). The concept of the geometric phase can be considered as a possible general explanation of the aging process.…”

Section: Resultsmentioning

confidence: 99%

“…In previous publications regarding the aging process in human beings, we have tried to understand this process as a consequence of the changes in the geometrics of the system (Barragán and Sánchez, 2015). We studied the relationship between the basal metabolism rate by unit of dry weight (BMR/kg DW) and the dry weight or the water-free weight DW in human beings.…”

Section: Introductionmentioning

confidence: 99%

“…After puberty, the capacity to self organize begins to slowly decline and from the point of view of the geometric system, this implies a gradual loss of the planarity thereof (Barragán and Sánchez, 2015). The parameter space suffers slow changes, which are seen in the behavior of the variables: cycle after cycle they no longer return to their original values.…”

Section: Introductionmentioning

confidence: 99%

“…Beyond the current theories of aging (Jin, 2010;Sergiev et al, 2015), we consider that, in a general mode, the same could be interpreted as the result of a geometric phase change that occurs in the system when it reaches a certain point in its evolution, that we identify as puberty (Barragán and Sánchez, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Human Biological Aging: A Vector Model

Barragán¹,

Sánchez²

2019

CRJBS

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Keeping in mind the relationship between the basal metabolic rate and the change in weight in the aging process, we propose to generate a model of the same. As a result of data transformation, we obtained a graphic representation that is consistent with the original data. This representation manifested that after puberty, the parameter space loses its initial planarity. Thus, the model helps to sustain that the geometric phase changes that occur when the parameter space undergoes a gradual curvature, can contribute to explaining the biological aging process.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human Biological Aging: A Vector Model

Barragán¹,

Sánchez²

2019

CRJBS

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“…Living things are complex physical systems coupled with oscillators [1] [2]. In a general way, they consist of a dissipative system, such as the enzymatic system of the Krebs cycle, associated with a self-organizing system, such as that of nucleic acids [3].…”

Section: Introductionmentioning

confidence: 99%

Aging and Biological Oscillation: A Question of Geometry

Barragán¹,

Sánchez²

2023

AAR

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Previous studies in different ethnic groups show changes in heart rate, respiratory rate, cortisol cycle, and sleep-wake cycle throughout life. Our purpose is to verify such changes by comparing the values of each variable before and after puberty. Puberty is associated with the end of growth and is an important point in our theoretical framework: when growth ends, changes occur in the geometry of the biological system. At the same time, this causes phase changes in the oscillatory variables, which are seen as chronodisruption. The results confirm the changes found by other authors in the evolution of the variables throughout life. Then, we can conclude that the variables studied present phase changes when growth ends, in accordance with the proposed theoretical framework.

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General determinants of aging: The size and geometry of living beings

Jorge,

Sebastián

2023

Arch Gerontol Geriatr Res

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The relationship between basal metabolic rate and weight changes which are a normal part of the human aging process can be represented in holographic form. The purpose of the study is to verify the validity of said representation through the development of the objectives, which are to examine the relationship between the total amount of energy lost and the amount of energy lost per unit of body mass, as well as the relationship that exists between the total amount of energy lost and body mass. There are previous studies that relate the size of living beings with their metabolic rate. Our study provides the foundation for the holographic description of that relationship. The analysis of the data allowed us to generate a coherent description of our notion using the tools at our disposal. According to the results of the study, there is a correlation that can be considered statistically significant between the basal metabolic rate per dry kilogram of an organism and the total amount of energy it expends. Based on this observation, we can conclude that the biological system in question satisfies the conditions of the holographic principle.

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Biological Aging: From the Boolean Networks, To the Geometric Phase

Cited by 4 publications

References 24 publications

Human Biological Aging: A Vector Model

Human Biological Aging: A Vector Model

Aging and Biological Oscillation: A Question of Geometry

General determinants of aging: The size and geometry of living beings

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