Biological and chemical sensors for cancer diagnosis

Simon, Elaine

doi:10.1088/0957-0233/21/11/112002

Cited by 46 publications

(25 citation statements)

References 99 publications

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“…From the 1980s until nowadays, a huge development in the sol-gel process was achieved. The research conducted allowed them to obtain OIH materials with applications in a wide range of areas, such as chemical and biosensors [13,85,86], in several transduction modes, from electrochemical [87][88][89][90][91] to optical [13,[92][93][94][95]; biomaterials for drug delivery [24,[96][97][98][99][100]; materials for improving bioactivity and biocompatibility of metallic substrates [101][102][103][104][105][106][107][108]; electronics [14]; environment [109][110][111]; optics [13,112,113]; medicine [53,[114][115][116][117]; functional smart coatings [31,38,73,118]; fuel and solar cells [119][120][121]…”

Section: Sol-gel Process: a Historical Perspective And Applicationsmentioning

confidence: 99%

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Figueira

2020

Polymers

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The corrosion process is a major source of metallic material degradation, particularly in aggressive environments, such as marine ones. Corrosion progression affects the service life of a given metallic structure, which may end in structural failure, leakage, product loss and environmental pollution linked to large financial costs. According to NACE, the annual cost of corrosion worldwide was estimated, in 2016, to be around 3%-4% of the world's gross domestic product. Therefore, the use of methodologies for corrosion mitigation are extremely important. The approaches used can be passive or active. A passive approach is preventive and may be achieved by emplacing a barrier layer, such as a coating that hinders the contact of the metallic substrate with the aggressive environment. An active approach is generally employed when the corrosion is set in. That seeks to reduce the corrosion rate when the protective barrier is already damaged and the aggressive species (i.e., corrosive agents) are in contact with the metallic substrate. In this case, this is more a remediation methodology than a preventive action, such as the use of coatings. The sol-gel synthesis process, over the past few decades, gained remarkable importance in diverse areas of application. Sol-gel allows the combination of inorganic and organic materials in a single-phase and has led to the development of organic-inorganic hybrid (OIH) coatings for several applications, including for corrosion mitigation. This manuscript succinctly reviews the fundamentals of sol-gel concepts and the parameters that influence the processing techniques. The state-of-the-art of the OIH sol-gel coatings reported in the last few years for corrosion protection, are also assessed. Lastly, a brief perspective on the limitations, standing challenges and future perspectives of the field are critically discussed.Polymers 2020, 12, 689 The development of OIH sol-gel coatings, based on siloxanes, for corrosion mitigation, has been widely studied in the last few years [2,31,[36][37][38]. Numerous studies have been conducted since the early 1990s [39,40]. The studies performed showed that siloxanes were effective in mitigating the corrosion processes of different metallic substrates. This development was mainly due to the need for alternative environmentally friend materials and processes to replace the traditional chromium-based pre-treatments. Hexavalent chromium (Cr (VI)) is carcinogenic and shows high environmental toxicity and its use has been forbidden since 2006. However, Cr(VI) based pre-treatments improve the coating adherence to the substrate and are effective corrosion inhibitors [41][42][43] which make its replacement challenging. The use of the sol-gel method to produce OIH coatings for corrosion mitigation suits the main requirements of what should be an environmentally friendly process (i.e., excludes washing stages; it is a waste-free method) and allows one to obtain coatings with high purity and specific pore volumes and surface areas. Since it is a mild synthesis...

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Section: Sol-gel Process: a Historical Perspective And Applicationsmentioning

confidence: 99%

Hybrid Sol–gel Coatings for Corrosion Mitigation: A Critical Review

Figueira

2020

Polymers

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“…A symposium held June 2005, "Moving Biosensors to Pointof-Care Cancer Diagnostics", sponsored by the Cancer Diagnostics Program of the National Cancer Institute, highlighted developments in biosensor technologies for detection of important cancer biomarkers [43]. Included are biosensors for proteins, peptides and tumor related metabolites, as well as biosensors to detect DNA mutations in tumor cells to indicate the presence or risk of cancer as well as to monitor therapy [44]. PSA is often used as a model cancer marker for demonstration of biosensor measurement principles.…”

Section: Biosensors For Cancer Biomarkersmentioning

confidence: 99%

Biosensors in clinical chemistry — 2011 update

D’Orazio¹

2011

Clinica Chimica Acta

159

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Research activity and applications of biosensors for measurement of analytes of clinical interest over the last eight years are reviewed. Nanotechnology has been applied to improve performance of biosensors using electrochemical, optical, mechanical and physical modes of transduction, and to allow arrays of biosensors to be constructed for parallel sensing. Biosensors have been proposed for measurement of cancer biomarkers, cardiac biomarkers as well as biomarkers for autoimmune disease, infectious disease and for DNA analysis. Novel applications of biosensors include measurements in alternate sample types, such as saliva. Biosensors based on immobilized whole cells have found new applications, for example to detect the presence of cancer and to monitor the response of cancer cells to chemotherapeutic agents. The number of research reports describing new biosensors for analytes of clinical interest continues to increase; however, movement of biosensors from the research laboratory to the clinical laboratory has been slow. The greatest impact of biosensors will be felt at point-of-care testing locations without laboratory support. Integration of biosensors into reliable, easy-to-use and rugged instrumentation will be required to assure success of biosensor-based systems at the point-of-care.

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“…Piezoelectric immunosensors are used primarily to identify markers associated with oncological, cardiovascular, autoimmune, allergic and infectious diseases. The nature of molecular markers is quite diverse -they are specific proteins (antibodies, enzymes) and non-specific protein molecules, glycoproteins and glicoconjugates, modified alkaloids, hormones, steroids, drugs and other high-or low-molecular metabolites (Wu et al 2007, Simon 2010, Martínez-Rivas et al 2010, Bohunicky et al 2011, Keusgen 2002, Malhotra et al 2003, Georganopoulou et al 2000, Mascini et al 2008). In addition, sensors can be used to identify microorganisms -bacteria, viruses, and phages.…”

Section: Application Of Piezoelectric Immunosensors For Medical Diagnmentioning

confidence: 99%