Biological and Clinical Aspects of Hyperthermia in Cancer Therapy

Oleson,; Calderwood, SK; Ct, Coughlin; Mw, Dewhirst; Le, Gerweck; Fa, Gibbs; Ds, Kapp

doi:10.1097/00000421-198806000-00013

Cited by 93 publications

(24 citation statements)

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“…2 In a clinical setting, hyperthermia is predominantly used in conjunction with other forms of cancer therapy, such as radiation therapy and chemotherapy. [3][4][5][6] Magnetic nanoparticle (MNP) hyperthermia as a cancer therapy operates on the principle that magnetic nanoparticles introduced into a tumor produce heat when subjected to an alternating magnetic field (AMF). There are a number of MNPs with different shapes and magnetic properties for Hyperthermia applications.…”

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confidence: 99%

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Shubitidze

Kekalo

Stigliano

et al. 2015

Journal of Applied Physics

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Magnetic nanoparticles (MNPs), referred to as the Dartmouth MNPs, which exhibit high specific absorption rate at low applied field strength have been developed for hyperthermia therapy applications. The MNPs consist of small (2-5 nm) single crystals of gamma-FeO with saccharide chains implanted in their crystalline structure, forming 20-40 nm flower-like aggregates with a hydrodynamic diameter of 110-120 nm. The MNPs form stable (>12 months) colloidal solutions in water and exhibit no hysteresis under an applied quasistatic magnetic field, and produce a significant amount of heat at field strengths as low as 100 Oe at 99-164 kHz. The MNP heating mechanisms under an alternating magnetic field (AMF) are discussed and analyzed quantitatively based on (a) the calculated multi-scale MNP interactions obtained using a three dimensional numerical model called the method of auxiliary sources, (b) measured MNP frequency spectra, and (c) quantified MNP friction losses based on magneto-viscous theory. The frequency responses and hysteresis curves of the Dartmouth MNPs are measured and compared to the modeled data. The specific absorption rate of the particles is measured at various AMF strengths and frequencies, and compared to commercially available MNPs. The comparisons demonstrate the superior heating properties of the Dartmouth MNPs at low field strengths (<250 Oe). This may extend MNP hyperthermia therapy to deeper tumors that were previously non-viable targets, potentially enabling the treatment of some of the most difficult cancers, such as pancreatic and rectal cancers, without damaging normal tissue.

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confidence: 99%

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Shubitidze

Kekalo

Stigliano

et al. 2015

Journal of Applied Physics

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“…The cytotoxic effect of hyperthermia is situated at several levels. At the cell level, hyperthermia induces the destruction of the lipid membranes, the disorganization of the cytoskeleton, a denaturation of intracellular proteins and formation of free radicals [25,26]. At the tissue level, hyperthermia induces microthrombosis that disrupts vascularization [27] and activates mechanisms of antitumor immune defense [28].…”

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confidence: 99%

Cytotoxic Effect of Hyperthermia and Chemotherapy with Platinum Salt on Ovarian Cancer Cells: Results of an in vitro Study

Muller

Chérel²,

Dupré

et al. 2011

Eur Surg Res

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Purpose: Hyperthermic intraperitoneal chemotherapy is continuously under evaluation in ovarian cancer. The purpose of the present study was to evaluate the effect of chemotherapy, drug concentration and temperature. Materials and Methods: A human ovarian carcinoma cell line was used. The effect of hyperthermia combined with chemotherapy was analyzed. Results: When hyperthermia was combined with chemotherapy, the 50% lethal dose (LD₅₀) decreased with the duration of exposure. The effect of temperature was similar between 39 and 43°C for a 30-min exposure. For a 60- to 90-min exposure, the LD₅₀ was equivalent between 38 and 43°C. Beyond 40°C, an increase in platinum salt concentration was necessary to obtain similar results according to the duration of exposure. Conclusions: The cytotoxic effect of the combination seemed to be potentiated and limited at 40°C.

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“…L'hyperthermie a son propre effet cytotoxique et potentialise l'effet de la CIP en augmentant notamment la pénétration intracellulaire des médicaments [36,37]. L'hyperthermie seule joue un rôle à la fois au niveau cellulaire, avec destruction des lipides membranaires, désorganisation du cytosquelette, dénaturation des protéines intracellulaires et formation de radicaux libres, et au niveau tissulaire, avec création de microthromboses qui perturbent la vascularisation et activent les défenses immunitaires antitumorales [38][39][40][41]. L'hyperthermie agit également par une augmentation de la perméabilité tissulaire [42,43].…”

Section: La Chimiothérapie Hyperthermique Intrapéritonéaleunclassified