“…However, the findings of these studies are variable and conflicting. Some studies reported regional cerebral atrophy in frontal, parietal, and temporal lobes (Brenneis et al., 2003; Goel et al., 2011; Hernandez‐Castillo et al., 2015; Mercadillo et al., 2014; Nave, Ginestroni, Tessa, Salvatore et al., 2008), while some studies found brain volume reductions limited in the infratentorial regions such as cerebellum and pons (D'Agata, Caroppo, Boghi et al., 2011; Jacobi et al., 2013; Nave, Ginestroni, Tessa, Cosottini et al., 2008; Olivito et al., 2018). The atrophy of mesencephalon and thalamus was also detected in a few studies (Brenneis et al., 2003; Nave, Ginestroni, Tessa, Salvatore et al., 2008), and significant parahippocampal atrophy was demonstrated in one study (Mercadillo et al., 2014).…”