Biological and Clinical Significance of Lipids as Modulators of Immune System Functions

Pablo, Manuel A. de; Puertollano, Marı́a A.; Cienfuegos, Gerardo Álvarez de

doi:10.1128/cdli.9.5.945-950.2002

Cited by 37 publications

(36 citation statements)

References 81 publications

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“…Dietary n-3PUFA are incorporated into cellular lipids where they exert essential effects on many biological systems, such as immune reactions, blood platelet aggregation and growth regulation of some cell types (De Pablo et al, 2002). In fact, in poultry, there are conflicting results on the effects of dietary lipids on immune functions (Wang et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

The impact of incorporation of n-3 fatty acids into eggs on ovarian follicular development, immune response, antioxidative status and tibial bone characteristics in aged laying hens

Ebeid

2011

Animal

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The objectives of this study were to investigate the effects of different dietary sources of unsaturated fatty acids (fish oil (FO) and/or linseed oil (LO)) on laying performance, egg yolk fatty acid composition, ovarian follicular development, antioxidative properties, immune response and tibial bone characteristics in aged laying hens. A total of 100 Hisex Brown hens at 56 weeks of age were housed individually in laying cages in an open-sided building under a 16 h light:8 h dark lighting schedule. Hens were randomly divided into four experimental treatments (n 5 25 each). Birds were fed ad libitum diets containing 2.5% vegetable oil (C, control), 2.5% FO, 2.5% LO and a mixture of 1.25% LO 11.25% FO (LO 1 FO) from 56 to 68 weeks of age. Egg production, egg quality characteristics and yolk lipid profile were analyzed. At 68 weeks of age, ovarian follicles were classified and tibial bone characteristics were determined. Serum thiobarbituric acid reactive substance (TBARS), glutathione peroxidase (GSH-Px) activity and total antioxidant capacity were measured. Incorporation of n-3 polyunsaturated fatty acids (n-3PUFA) into the egg yolks has been successful by using dietary FO and/or LO. There were no significant effects of treatments on hen-day egg production, feed intake, egg weight, egg shape index, albumen height, Haugh units and yolk height. However, dietary FO and/or LO supplementation had a significantly positive effect on eggshell percentage, eggshell thickness and yolk color. At 68 weeks of age, there was no significant difference among dietary treatments for tibial bone measurements. Also, no negative effects were detected in ovarian follicular development and weights of the ovary and oviduct, expressed in both absolute terms and relative to body weight. Dietary 2.5% LO, 2.5% FO and a mixture of 1.25% FO 1 1.25% LO enhanced GSH-Px activity, total antioxidant capacity and antibody titers significantly in comparison with control. It could be concluded that inclusion of mixed sources of n-3PUFA in diets at moderate levels (2.5%) increased the n-3PUFA content and decreased the n-6/n-3 ratio content in the yolk, improved the antioxidative status, reduced lipid peroxidation, enhanced the antibody response and did not have any negative influence on ovarian follicular development and tibial bone characteristics in aged laying hens.

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Section: Introductionmentioning

confidence: 99%

The impact of incorporation of n-3 fatty acids into eggs on ovarian follicular development, immune response, antioxidative status and tibial bone characteristics in aged laying hens

Ebeid

2011

Animal

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“…Dietary n-3 PUFA are incorporated into cellular lipids where they exert essential effects on many biological systems, such as immune reactions, blood platelet aggregation and growth regulation of some cell types (De Pablo et al, 2002). In fact, the immunomodulatory functions of dietary n-3 PUFA have been widely studied in mammals, but research on poultry is limited.…”

mentioning

confidence: 99%

Ovarian follicular development, lipid peroxidation, antioxidative status and immune response in laying hens fed fish oil-supplemented diets to produce n-3-enriched eggs

Ebeid

Eid

Saleh

et al. 2008

Animal

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The objective of the present study was to research the effect of feeding laying hens fish oil-supplemented diets to produce n-3-enriched eggs on their ovarian follicular development, serum lipid peroxidation, antioxidative status and immune response. A total of 105 white Bovens hens at 24 weeks of age were housed in cages in an open-sided building under a 16 h light : 8 h dark lighting schedule. Birds were randomly divided into five treatments and were fed, ad libitum, diets containing 0% (control), 1.25%, 2.5%, 3.5% or 5.0% fish oil from 24 to 36 weeks of age. Egg production and weight were recorded. By weeks 35 and 36 of age 15 eggs were taken at random from each treatment to determine the yolk lipid profile and cholesterol content. At the end of the experimental period, 10 females from each treatment were randomly chosen, anaesthetised and killed by decapitation. Ovary and oviduct samples were immediately weighted and ovarian follicles were classified. Serum thiobarbituric acid-reactive substance (TBARS), hepatic TBARS and hepatic glutathione peroxidase (GSH-Px) activity were measured. No clear trend was observed concerning egg production and egg yolk cholesterol. As dietary fish oil levels increased, n-3-polyunsaturated fatty acids (n-3 PUFA) increased, whereas n-6 PUFA tended to decrease in yolk lipids. No negative effects were detected in ovary and oviduct weights, expressed in both absolute terms and relative to body weight. The numbers and total weights of large yellow follicles (LYF) in the ovary were not significantly affected by fish oil supplementation. Low levels (1.25% to 2.5%) of fish oil reduced both plasma and hepatic TBARS and enhanced GSH-Px activity. It is also interesting to note that inclusion of 2.5% fish oil in laying hen diets enhanced the antibody titre in laying hens. Therefore, it could be concluded that inclusion of fish oil in laying hen diets at moderate levels increased the n-3 fatty acids content in eggs, improved antioxidative status, enhanced the antibody response and did not have a negative influence on the different reproductive morphology parameters in laying hens.

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“…Studies on dietary lipid and fish immune system have been emphasized on because incorporation of vegetable oils in diets may result in the potential imbalance of n-3 to n-6 fatty acids and thereafter directly or indirectly affect immune system and disease resistance in fish (Pablo et al, 2002;Montero et al, 2003). Recent research has shown that fish immunity is compromised when fish oil is replaced with vegetable oils in Epinephelus malabaricus (Lin and Shiau, 2007), Ictalurus punctatus (Fracalossi and Lovell, 1994), Psetta maxima (Regost et al, 2003), Salmo salar L. (Brandsen et al, 2003) and Sparus aurata (Montero et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary soybean oil inclusion to replace fish oil on growth, muscle fatty acid composition, and immune responses of juvenile darkbarbel catfish, Pelteobagrus vachelli

Jiang¹,

Chen²,

Qin³

et al. 2013

Afr. J. Agric. Res.

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An 80 day feeding trial was conducted to evaluate the effects of dietary inclusion of soybean oil to replace fish oil in the diet on growth, muscle fatty acids and immune responses of Pelteobagrus vachelli. Isonitrogenous and isocaloric diets were formulated with four fish oil to soybean oil ratios at 8:0 (FO, control), 6:2 (MO1), 2:6 (MO2) and 0:8 (SO) in triplicate. Each diet was fed to juvenile darkbarbel catfish (1.0 ± 0.02 g) twice daily. No significant differences were found in weight gain, special growth rate, hepatosomatic index and intraperitoneal fat ratio among all the treatments. Incorporation of soybean oil significantly modified the fatty acid composition and n-3 and n-6 PUFAs ratio in muscle of fish. Fish fed MO1 showed significantly higher serum lysozyme activity, complement C3 and C4 contents and total IgM content than those fed other diets. These results indicate that partial replacement of fish oil with soybean oil does not compromise fish growth, but improve fish immunity. This study suggests that 25% fish oil replacement with soybean oil can be used in the practical diet of this fish.

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Biological and Clinical Significance of Lipids as Modulators of Immune System Functions

Cited by 37 publications

References 81 publications

The impact of incorporation of n-3 fatty acids into eggs on ovarian follicular development, immune response, antioxidative status and tibial bone characteristics in aged laying hens

The impact of incorporation of n-3 fatty acids into eggs on ovarian follicular development, immune response, antioxidative status and tibial bone characteristics in aged laying hens

Ovarian follicular development, lipid peroxidation, antioxidative status and immune response in laying hens fed fish oil-supplemented diets to produce n-3-enriched eggs

Effects of dietary soybean oil inclusion to replace fish oil on growth, muscle fatty acid composition, and immune responses of juvenile darkbarbel catfish, Pelteobagrus vachelli

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