Biological and Hemodynamic Effects of Low Doses of Fludrocortisone and Hydrocortisone, Alone or in Combination, in Healthy Volunteers With Hypoaldosteronism

Laviolle, Bruno; Maguet, Pascale Le; Verdier, M. C.; Massart, Catherine; Donal, Erwan; Lainé, Fabrice; Lavenu, Audrey; Pape, Danielle

doi:10.1038/clpt.2010.83

Cited by 12 publications

(24 citation statements)

References 37 publications

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“…The concentration response curves to BUC(NO) 2 were significantly shifted to the right in the presence of ODQ 5 lM (pD 2 4.7 AE 0.1) and bacitracin 100 lM (pD 2 6.8 AE 0.2). Conclusion: We successfully synthesized the new dinitrosothiol BUC(NO) 2 with a satisfactory purity degree and stability.…”

Section: -10mentioning

confidence: 97%

“…Conclusion: We successfully synthesized the new dinitrosothiol BUC(NO) 2 with a satisfactory purity degree and stability. Our data showed that BUC(NO) 2 releases a large amount of…”

Section: -10mentioning

confidence: 98%

“…C De Bisschop 2 were observed at maximal exercise in highlanders likely due to lower ventilation. Overall these findings do not favor the hypothesis of a blood shift to respiratory muscles.…”

Section: -07mentioning

confidence: 99%

“…Results: Expressed as means AE SEM, one way ANOVA test. Synthesized BUC(NO) 2 was structurally characterized, exhibited a high purity (99.5 AE 0.1 %, n = 6 batches) and was stable during 4 days when prepared in ultra-pure water and stored at 4°C, pH < 0.5. BUC(NO) 2 induced a higher concentration-dependent vasodilatation than the mixture of SNAP + NACNO (pD 2 7.8 AE 0.1 and 6.7 AE 0.2, respectively P < 0.05).…”

Section: -10mentioning

confidence: 99%

“…The release of • NO from BUC(NO) 2 into the aorta was measured using 4,5-diaminofluorescein diacetate. Effects of BUC(NO) 2 were compared to an equimolar mixture of NACNO plus SNAP. Involvement of cytosolic soluble guanylate cyclase (sGC) and membrane protein disulfide isomerase (PDI), an enzyme involved in…”

Section: -10mentioning

confidence: 99%

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2013

Fundamemntal Clinical Pharma

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Bone is the only tissue of the vertebrate body that contains a cell type, the osteoclast, whose only function is to destroy the host tissue. This does not occur at random but rather in the context of a well ordered physiological process called bone modeling during childhood and remodeling during adulthood. We hypothesized that this process requires a daily delivery of a large amount of energy to bone cells; a large body of clinical observations supports this hypothesis. Testing this hypothesis led us to reveal the bone endocrine nature of bone and to identify osteocalcin as an osteoblast-derived hormone affecting multiple aspects of energy metabolism. We will review during this lecture the functions and mode of action of osteocalcin and address its overall importance in the control of whole body glucose homeostasis. SESSION 1: GS MIXTE RESPIRATIONBitter taste receptors in the lung: a new pharmacological target? S Grassin-Delyle a a UPRES EA220, Hôpital Foch, Universit e Versailles Saint Quentin en Yvelines, Saint Quentin en Yvelines Bitter taste receptors (TAS2Rs) are known for long for their role in taste as sensors of the presence of toxic compounds in foods, but their unexpected expression in airways epithelium and smooth muscle cells or in peripheral blood leucocytes has been recently documented. This family of GPCRs includes about 25 members in humans and each subtype has a variable selectivity towards bitter compounds, some of them being restrictedly selective to a unique molecule and others responding to a wider range. More than a hundred molecules such as chloroquine, caffeine, strychnine, colchicine or erythromycin have thus been described as TAS2R agonists while TAS2R19, 41, 42, 45 and 60 are considered as orphans since no agonist has been identified. In the airways, the initial observation by Desphandes et al. (2010) described the relaxation of pre-contracted mouse trachea following exposure to chloroquine, denatonium, quinine or saccharine, which was suggested to be even more pronounced that the relaxation obtained with the reference relaxing agents b2 -adrenoreceptor agonists. Interestingly, an original intracellular signaling pathway in the response of airway smooth muscle cells to bitter-taste receptor agonists was proposed, involving the G-protein bc subunit and leading to a localized increase in intracellular calcium, which in turn causes membrane hyperpolarisation through an activation of large conductance potassium channels (BK Ca). In addition to these results in cell cultures or airways preparations, inhaled bitter tastants were shown effective in decreasing airway resistance in ovalbumin-sensitized mice, but very little is known in humans to date. However, transcriptome analysis revealed upregulation of TAS2R signaling in peripheral blood leucocytes from patients with severe asthma, as well as a correlation between clinical markers of asthma severity and TAS2R expression. Overall, these works suggest that bitter taste receptors may constitute a new pharmacological target for obstructive l...

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Section: -10mentioning

confidence: 97%

“…Conclusion: We successfully synthesized the new dinitrosothiol BUC(NO) 2 with a satisfactory purity degree and stability. Our data showed that BUC(NO) 2 releases a large amount of…”

Section: -10mentioning

confidence: 98%

Section: -07mentioning

confidence: 99%

Section: -10mentioning

confidence: 99%

Section: -10mentioning

confidence: 99%

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2013

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Neuroendocrine Dysfunction in the Critically Ill Patients

Roquilly

Asehnoune

2017

Metabolic Disorders and Critically Ill Patients

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Bildgebung und präoperative Planung bei perigenikulären Osteotomien

Pape

Hoffmann

Seil

2017

Oper Orthop Traumatol

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Physiologic alignment of the human lower leg is well defined. The etiology for malalignment comprises constitutional, degenerative and posttraumatic conditions. Osteotomies around the knee can correct the malalignment, provided that the origin of deviation is in proximity of the knee center. Crucial factors for the evaluation of axis deviation are the weight-bearing line, the mechanical axes of femur and tibia, the joint line angles and the center of the hip, knee and upper ankle joint. Careful preoperative planning is mandatory for reproducible clinical results. For the treatment of varus osteoarthritis of the knee, a slight overcorrection to the 62% width of the lateral tibial plateau is frequently advocated. In valgus knees, a correction of the postoperative weight-bearing line to physiologic conditions (44% of the lateral tibial width) is regarded to be sufficient. Recently, individualized planning of the correction angle is advocated to better address the underlying pathology of each patient.

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Biological and Hemodynamic Effects of Low Doses of Fludrocortisone and Hydrocortisone, Alone or in Combination, in Healthy Volunteers With Hypoaldosteronism

Cited by 12 publications

References 37 publications

Untitled

Untitled

Neuroendocrine Dysfunction in the Critically Ill Patients

Bildgebung und präoperative Planung bei perigenikulären Osteotomien

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