Biological and Mechanical Properties of Nanohydroxyapatite‐Containing Carbon/Carbon Composites

Mikociak, D.; Błażewicz, S.; Michałowski, J.

doi:10.1111/j.1744-7402.2011.02643.x

Cited by 16 publications

(6 citation statements)

References 24 publications

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“…Spinal fusion is widely used in clinical for intervertebral decompression which aims at complete bony fusion. So, these materials have good performance for intervertebral fusion, especially after being reinforced by fibers such as PLA, PEG, or carbon fibers [ 88 – 90 ]. Though fusion is not the ideal choice for disc repair, FRMs used for fusion materials are also a research hotspot at present.…”

Section: The Application Of Frm In Disc Arthroplastymentioning

confidence: 99%

The Application of Fiber-Reinforced Materials in Disc Repair

Pei

Zhu

et al. 2013

BioMed Research International

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The intervertebral disc degeneration and injury are the most common spinal diseases with tremendous financial and social implications. Regenerative therapies for disc repair are promising treatments. Fiber-reinforced materials (FRMs) are a kind of composites by embedding the fibers into the matrix materials. FRMs can maintain the original properties of the matrix and enhance the mechanical properties. By now, there are still some problems for disc repair such as the unsatisfied static strength and dynamic properties for disc implants. The application of FRMs may resolve these problems to some extent. In this review, six parts such as background of FRMs in tissue repair, the comparison of mechanical properties between natural disc and some typical FRMs, the repair standard and FRMs applications in disc repair, and the possible research directions for FRMs' in the future are stated.

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Section: The Application Of Frm In Disc Arthroplastymentioning

confidence: 99%

The Application of Fiber-Reinforced Materials in Disc Repair

Pei

Zhu

et al. 2013

BioMed Research International

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“…One is that the C/C composites are surrounded by a connective tissue layer, and cannot chemically bond to the surrounding bone tissue. The other is that significant amount of carbon debris is founded in adjacent tissues and in the lymph nodes because of abrasive wear of the surface of the C/C implant [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The effect of electromagnetic heating frequencies on CaHPO4 coatings deposited on the C/C by induction heating deposition technology

Xiong

Miaomiao

Xing

et al. 2015

Surface and Coatings Technology

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“…Therefore, HA/carbon fiber composite is a very promising biomaterial for bone tissue engineering, which combines the advantages of HA and carbon fibers. Many efforts have been put into the fabrication of HA/carbon fiber composite by plasma spraying technique, 22 in situ polymerization with a later solution co-mixing approach, 23 or electrochemical deposition. 24 However, these synthetic scaffolds are different from natural bone in the chemical composition, microstructure, and biological property.…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal fabrication of hydroxyapatite/chitosan/carbon porous scaffolds for bone tissue engineering

et al. 2014

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Porous carbon fiber felts (PCFFs) have great applications in orthopedic surgery because of the strong mechanical strength, low density, high stability, and porous structure, but they are biologically inert. To improve their biological properties, we developed, for the first time, the hydroxyapatite (HA)/chitosan/carbon porous scaffolds (HCCPs). HA/chitosan nanohybrid coatings have been fabricated on PCFFs according to the following stages: (i) deposition of chitosan/calcium phosphate precursors on PCFFs; and (ii) hydrothermal transformation of the calcium phosphate precursors in chitosan matrix into HA nanocrystals. The scanning electron microscopy images indicate that PCFFs are uniformly covered with elongated HA nanoplates and chitosan, and the macropores in PCFFs still remain. Interestingly, the calcium-deficient HA crystals exist as plate-like shapes with thickness of 10-18 nm, width of 30-40 nm, and length of 80-120 nm, which are similar to the biological apatite. The HA in HCCPs is similar to the mineral of natural bone in chemical composition, crystallinity, and morphology. As compared with PCFFs, HCCPs exhibit higher in vitro bioactivity and biocompatibility because of the presence of the HA/chitosan nanohybrid coatings. HCCPs not only promote the formation of bone-like apatite in simulated body fluid, but also improve the adhesion, spreading, and proliferation of human bone marrow stromal cells. Hence, HCCPs have great potentials as scaffold materials for bone tissue engineering and implantation.

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Biological and Mechanical Properties of Nanohydroxyapatite‐Containing Carbon/Carbon Composites

Cited by 16 publications

References 24 publications

The Application of Fiber-Reinforced Materials in Disc Repair

The Application of Fiber-Reinforced Materials in Disc Repair

The effect of electromagnetic heating frequencies on CaHPO4 coatings deposited on the C/C by induction heating deposition technology

Hydrothermal fabrication of hydroxyapatite/chitosan/carbon porous scaffolds for bone tissue engineering

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