Biological and mutational analyses of CXCR4–antagonist interactions and design of new antagonistic analogs
Qian Meng,
Ruohan Zhu,
Yujia Mao
et al.
Abstract:The chemokine receptor CXCR4 has become an attractive therapeutic target for HIV-1 infection, hematopoietic stem cell mobilization, and cancer metastasis. A wide variety of synthetic antagonists of CXCR4 have been developed and studied for a growing list of clinical applications. To compare the biological effects of different antagonists on CXCR4 functions and their common and/or distinctive molecular interactions with the receptor, we conducted head-to-head comparative cell-based biological and mutational ana… Show more
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