Biological and Nonbiological Antioxidant Activity of Some Essential Oils

Pérez-Rosés, Renato; Risco, Ester; Vila, Roser; Peñalver, Pedro; Cañigueral, Salvador

doi:10.1021/acs.jafc.6b00986

Cited by 85 publications

(54 citation statements)

References 45 publications

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“…Thymol (250 and 500 μM) strongly inhibited nicotinamide adenine dinucleotide phosphate reduced (NADPH)-cytochrome-c reductase mediated lipid peroxidation isolated from detergent solubilized liver microsomes of rats (Kamataki et al, 1978). Thymol attenuated the production of reactive oxygen species (ROS) and showed myeloperoxidase inhibitory activity in human neutrophils (Perez-Roses et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

et al. 2017

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Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline monoterpene phenol. It is one of the most important dietary constituents in thyme species. For centuries, it has been used in traditional medicine and has been shown to possess various pharmacological properties including antioxidant, free radical scavenging, anti-inflammatory, analgesic, antispasmodic, antibacterial, antifungal, antiseptic and antitumor activities. The present article presents a detailed review of the scientific literature which reveals the pharmacological properties of thymol and its multiple therapeutic actions against various cardiovascular, neurological, rheumatological, gastrointestinal, metabolic and malignant diseases at both biochemical and molecular levels. The noteworthy effects of thymol are largely attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and chemokines), antioxidant (via scavenging of free radicals, enhancing the endogenous enzymatic and non-enzymatic antioxidants and chelation of metal ions), antihyperlipidemic (via increasing the levels of high density lipoprotein cholesterol and decreasing the levels of low density lipoprotein cholesterol and low density lipoprotein cholesterol in the circulation and membrane stabilization) (via maintaining ionic homeostasis) effects. This review presents an overview of the current in vitro and in vivo data supporting thymol’s therapeutic activity and the challenges concerning its use for prevention and its therapeutic value as a dietary supplement or as a pharmacological agent or as an adjuvant along with current therapeutic agents for the treatment of various diseases. It is one of the potential candidates of natural origin that has shown promising therapeutic potential, pharmacological properties and molecular mechanisms as well as pharmacokinetic properties for the pharmaceutical development of thymol.

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Section: Introductionmentioning

confidence: 99%

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

et al. 2017

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“…Nutmeg oil diminished chronic inflammation and pain through the inhibition of COX-2 expression and substance P release in vivo [16]. In another study, nutmeg oil suppressed reactive oxygen species (ROS) production in human neutrophils stimulated by PMA (phorbol 12-myristate 13-acetate) [17] and mildly inhibited phagocytosis in human neutrophils [18]. However, there is no published research on the effect of nutmeg seed essential oil on virus-triggered inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity

Matulytė

Jekabsone

Jankauskaitė

et al. 2020

Foods

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Nutmeg (Myristica fragrans) essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content and amount of bioactive substances in the oil and hydrolats. In this study, we aimed to compare the antioxidant, antimicrobial, and anti-inflammatory activity of hydrolats and essential oil obtained by hydrodistillation in the presence and absence of magnesium aluminometasilicate as an excipient. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method revealed that magnesium aluminometasilicate did not significantly improved antioxidant activity of both essential oil and hydrolat. Antibacterial efficiency was evaluated by monitoring growth of 15 bacterial strains treated by a range of dilutions of the essential oil and the hydrolats. Essential oil with an excipient completely inhibited the growth of E. faecalis, S. mutans (referent), and P. multocida, whereas the pure oil was only efficient against the latter strain. Finally, the anti-inflammatory properties of the substances were assessed in a fibroblast cell culture treated with viral dsRNR mimetic Poly I:C. The essential oil with an excipient protected cells against Poly I:C-induced necrosis more efficiently compared to pure essential oil. Also, both the oil and the hydrolats with aluminometasilicate were more efficient in preventing IL-6 release in the presence of Poly I:C. Our results show that the use of magnesium aluminometasilicate as an excipient might change and in some cases improve the biological activities of nutmeg essential oil and hydrolats.

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“…Some studies point out that these diseases may be consequences of damages caused by free radicals, besides oxygen and reactive nitrogen species that act as mediators of inflammation as messenger molecules. This shows that essential oils can also act as an anti-inflammatory agent [31][32][33].…”

Section: Antioxidant Activitymentioning

confidence: 87%

“…In addition, they are often treated as foods to enhance the taste and organoleptic properties, and even has the function of decreasing the process of deterioration of food. The latter is mainly due to its antimicrobial and antioxidants activities [31,34,35].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Potential of Medicinal Use of Essential Oils from Aromatic Plants

Oliveira¹,

Almeida²,

Salazar³

et al. 2018

Potential of Essential Oils

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The use of medicinal plants rich in essential oils can represent a viable source for the control of some diseases, being able to constitute a possible therapeutic alternative due to its effectiveness. Essential oils are natural volatile fractions extracted from aromatic plants and formed by classes of substances such as esters of fatty acids, mono and sesquiterpenes, phenylpropanoids, aldehyde alcohols and, in some cases, aliphatic hydrocarbons, among others. Essential oils have been used by mankind for medicinal purposes for several centuries, with reports coming from Ancient Egypt. In this sense, the present work aims to approach the biological activities of essential oils such as antioxidant, anticancer, antiprotozoal, antifungal, antibacterial and anti-inflammatory activities of different plant matrices rich in essential oils.

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Biological and Nonbiological Antioxidant Activity of Some Essential Oils

Cited by 85 publications

References 45 publications

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity

Potential of Medicinal Use of Essential Oils from Aromatic Plants

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