2024
DOI: 10.3390/jcm13030806
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Biological and Physical Performance Markers for Early Detection of Cognitive Impairment in Older Adults

Hanna Kerminen,
Emanuele Marzetti,
Emanuela D’Angelo

Abstract: Dementia is a major cause of poor quality of life, disability, and mortality in old age. According to the geroscience paradigm, the mechanisms that drive the aging process are also involved in the pathogenesis of chronic degenerative diseases, including dementia. The dissection of such mechanisms is therefore instrumental in providing biological targets for interventions and new sources for biomarkers. Within the geroscience paradigm, several biomarkers have been discovered that can be measured in blood and th… Show more

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Cited by 3 publications
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“…Oxidative stress and inflammation are recognized as pivotal contributors and common features of several chronic degenerative diseases, including cancer, metabolic syndrome, type 2 diabetes, cardiovascular diseases and neurodegenerative disorders, affecting a high percentage of the population [1,2]. Oxidative stress is characterized by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify them or repair the resulting damage [3]; inflammation is a natural and necessary biological response to protect the organism from injury, infection or exposure to harmful stimuli.…”
mentioning
confidence: 99%
“…Oxidative stress and inflammation are recognized as pivotal contributors and common features of several chronic degenerative diseases, including cancer, metabolic syndrome, type 2 diabetes, cardiovascular diseases and neurodegenerative disorders, affecting a high percentage of the population [1,2]. Oxidative stress is characterized by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify them or repair the resulting damage [3]; inflammation is a natural and necessary biological response to protect the organism from injury, infection or exposure to harmful stimuli.…”
mentioning
confidence: 99%