1958
DOI: 10.1099/00221287-19-1-23
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Biological and Physical Properties of the Ryan Strain of Filamentous Influenza Virus

Abstract: SUMMARY: An influenza A strain, Ryan, isolated in Melbourne in 1954 contains on a particle basis about 20% filaments. By using the electron microscope for particle counting, the efficiency as haemagglutinin of Ryan 'long' filaments (particles in which length : width > 6) was estimated to be about 6 times greater than that of spheres of PR8 virus. Allantoic fluid preparations of Ryan virus have high values for the ratio (log) EID50:AD and estimates indicate that a maximum of 6 'long' filaments are equivalent to… Show more

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Cited by 31 publications
(24 citation statements)
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“…The demonstration of virus rods in cells infected with VS virus bears some similarity to observations made in studies of influenza virus. Besides spherical influenza virus particles, filamentous forms of this virus are often detected in preparations of recently isolated strains (12)(13)(14)(15), and evidence was reported that these filaments are infective (14)(15)(16). However, the filaments seem to be formed by extrusion from the virus-infected cell (17)(18)(19)(20)(21)(22).…”
Section: Figures ~ Andmentioning
confidence: 99%
“…The demonstration of virus rods in cells infected with VS virus bears some similarity to observations made in studies of influenza virus. Besides spherical influenza virus particles, filamentous forms of this virus are often detected in preparations of recently isolated strains (12)(13)(14)(15), and evidence was reported that these filaments are infective (14)(15)(16). However, the filaments seem to be formed by extrusion from the virus-infected cell (17)(18)(19)(20)(21)(22).…”
Section: Figures ~ Andmentioning
confidence: 99%
“…Considerable evidence has now been obtained to show that the filament forms by extrusion from the virus-infected cell (7)(8)(9)(10)(11)(12)(13), and there are indications that the filament may contain host cell as well as viral constituents (14,15). Evidence has been reported that filaments are infective (15)(16)(17).…”
mentioning
confidence: 99%
“…An estimate of the amount and localization within the filament of these and of specific virus components would throw light on the structure of a filament. Due to the large difference in their properties, spherical virus type RNA and host cell type RNA are suitable markers in such an investigation, The finding (Ada, Perry & Abbot, 1958) of the infectious nature of Ryan filaments enhanced the interest attached to a study of the amount, type and properties of nucleic acid present in purified preparations of Ryan filaments. The results of such an investigation are reported in this paper.…”
mentioning
confidence: 99%