Bi̇ologi̇cal and Phytochemi̇cal İnvesti̇gati̇ons of Extracts From Pterocarpus Eri̇naceus Poi̇r (Fabaceae) Root Barks

Abstract

Background: Pterocarpus erinaceus Poir. belonging to Fabacae familly is used as medicinal plant in Burkina Faso's folk medicine.Roots of P. erinaceus are used to treat ulcer, stomach ache and inflammatory diseases. The objective of the present study was to carry out phytochemical composition of methanol (MeOH) and dichloromethane (DCM) extracts from Pterocarpus erinaceus roots, to isolate pure compounds, and to evaluate their pharmacological activities. Methods:Chromatographic fractionation led to the isolation of active components of the extracts. The structures were established by NMR analysis and comparison with data from literature. The anti-inflammatory activity was evaluated using croton oil-induced edema of mice ear as well as the effect of extracts against lipoxygenase and lipid peroxidation was evaluated. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Cupric-reducing antioxidant capacity (CUPRAC) methods were used to evaluate the antioxidant activity of the extracts.Results: Friedelin (1), 3α-hydroxyfriedelan-2-one (2), α-sophoradiol (3) and stigmasterol (4) were isolated from DCM extract and maltol-6-O-apiofuranoside-glucopyranoside (5) isolated from MeOH. DCM extract and friedelin, 3α-hydroxyfriedelan-2-one, α-sophoradiol showed a significant anti-inflammatory effect against ear edema. Friedelin (1), α-sophoradiol (3) and maltol-6-Oapiofuranoside-glucopyranoside (5) exhibited lipoxygenase inhibition. MeOH extract (100 µg/mL) inhibited lipoxygenase and lipid peroxidation activities at 45.1 ± 3% and 30.7 ± 0.5% respectively. MeOH extract, ethyl acetate fraction and butanol fraction exhibited antioxidant property with both two methods used. Conclusion:The results suggested that the extracts and compounds from roots of Pterocarpus erinaceus possessed local antiinflammatory effect, antioxidant properties and inhibitor effect against lipoxygenase and lipid peroxidation activities.

Integrating Chemical Profiling, In Vivo Study, and Network Pharmacology to Explore the Anti-inflammatory Effect of Pterocarpus dalbergioides Fruits and Its Correlation with the Major Phytoconstituents

“…Alcoholic extracts of flowers, bark, and wood demonstrated anti-diabetic effect. Numerous studies have been conducted on the anti-inflammatory activities of phytochemicals found in the genus Pterocarpus. − These findings are consistent with the plant’s traditional use in the treatment of inflammation and boils . Only one report was found about the anti-inflammatory activity of the bark; however, nothing has been reported about the biological activity and compounds of Andaman padauk fruits.…”

study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases

“…18 Other authors also report that antioxidant substances can prevent and delay lipid oxidation by acting on the reduction of ROS and the production of other free radicals. 19 The antiradical activity of the extracts varied between 7.29 ± 0.61 and 43.31 ± 0.25 µg/mL and 2.69 ± 0.25 µg/mL for gallic acid. Recurrently, the hydroethanolic extracts gave the best antiradical activities.…”

Ethno-veterinary practice for the treatment of cattle diseases in the Eastern highlands of Nigeria

“…The widespread use of some of these plant species could be related to the chemical Diseases/Ailment Recorded compounds they contain (such as sterols, carbohydrates, proteins, amino acids, alkaloids coumarins, saponins, tannins, flavonoids, phenols, and saponins) and/or their antimicrobial, digestive or laxative capacity. These chemicals are also known to have important anthelmintic activities or contribute to healing of the ailments mentioned above (Akinpelu et al 2009;Aliyu and Chedi 2010;Noufou et al 2016;Ouachinou et al 2019).…”