Biological applications of chiral inorganic nanomaterials

Fan, Yuan; Ou-Yang, Shaobo; Zhou, Dong; Wei, Junchao; Lan, Lei

doi:10.1002/chir.23428

Cited by 29 publications

(18 citation statements)

References 127 publications

(249 reference statements)

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“…Yield: 39.5%. 1 (4). A solution of AgNO 3 (17 mg, 0.1 mmol) in acetonitrile (40 mL) was added dropwise to ligand L 1 (53 mg, 0.1 mmol) in chloroform (30 mL).…”

Section: Methodsmentioning

confidence: 99%

“…Chirality is considered a fundamental feature in natural processes and plays an integral role in many chemical and biological processes. − Currently, chiral metal complexes are widely used in asymmetric synthesis and catalysis, , enantiomeric separation, and supramolecular chemistry due to their ability to create asymmetric environments. − They are also widely used in chiral liquid crystals, chiral luminescent materials, − enantioselective sensors, , magnetic chiral compounds, and chiral reagents. , Typically, enantiomerically pure chiral ligands are used to construct chiral metal complexes. , However, metal complexes prepared from racemic ligands create more complex situations in which the possibility of chiral self-discrimination (heterochiral aggregation) and chiral self-recognition (homochiral aggregation) is feasible. Therefore, their self-assembly can be significantly different with racemic ligands having the potential to form novel and interesting molecular materials. − Helicity is one important origin of chirality.…”

Section: Introductionmentioning

confidence: 99%

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Coordination-Driven Self-Assembly of Complexes Constructed from Two Helical Ligands: Synthesis, Structures, and Selective Gas Adsorption Properties

Huang

Tian

et al. 2022

Inorg. Chem.

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Two helical ligands (L 1 and L 2 ) were designed and synthesized by a Schiff base condensation reaction. Eight complexes, {[Zn(L, were synthesized and characterized based on these two ligands. The crystal structures show that both Schiff base compounds exist as racemic ligands with equal amounts of P-and M-helicity, and the assembly of these racemic ligands with metal ions can lead to homochiral or heterochiral complexes via a chiral self-recognition or self-discrimination process. Complexes 2, 3, and 5 exist as heterochiral metallomacrocycles with a figure-eight conformation. Complexes 1, 6, and 8 exist as one-dimensional (1D) homochiral helical chain coordination polymers, while complexes 4 and 7 exist as 1D heterochiral helical chain coordination polymers. Furthermore, gas and vapor adsorption measurements show that all of the synthesized complexes exhibit good selective adsorption capacities toward methanol and ethanol vapor over N 2 , H 2 , and O 2 .

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“…Yield: 39.5%. 1 (4). A solution of AgNO 3 (17 mg, 0.1 mmol) in acetonitrile (40 mL) was added dropwise to ligand L 1 (53 mg, 0.1 mmol) in chloroform (30 mL).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Coordination-Driven Self-Assembly of Complexes Constructed from Two Helical Ligands: Synthesis, Structures, and Selective Gas Adsorption Properties

Huang

Tian

et al. 2022

Inorg. Chem.

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“…Chiral inorganic nanomaterials may be applied for various biomedical and bioengineering applications, such as sensing, photothermal and photodynamic cancer therapy, and neurodegenerative disease therapy 211 . The handedness-dependent physicochemical properties of chiral inorganic nanomaterials can be exploited to modulate biological components at the nanoscale, such as site-selective biocatalytic activities or immune response activation.…”

Section: Discussionmentioning

confidence: 99%

Bioinspired chiral inorganic nanomaterials

et al. 2023

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From small molecules to entire organisms, evolution has refined biological structures at the nanoscale, microscale and macroscale to be chiral-that is, mirror dissymmetric. Chirality results in biological, chemical and physical properties that can be influenced by circularly polarized electromagnetic fields. Chiral nanoscale materials can be designed that mimic, refine and advance biological chiral geometries, to engineer optical, physical and chemical properties for applications in photonics, sensing, catalysis and biomedicine. In this Review, we discuss the mechanisms underlying chirality transfer in nature and provide design principles for chiral nanomaterials. We highlight how chiral features emerge in inorganic materials during the chemical synthesis of chiral nanostructures, and outline key applications for inorganic chiral nanomaterials, including promising designs for biomedical applications, such as biosensing and immunomodulation. We conclude Nature Reviews Bioengineering Review article nanostructures). We describe hierarchical multiscale chirality in biological systems (for example, cytoskeleton hypothesis and chirality in biominerals), and analyse the most abundant chirality transfer mechanisms in biology, including enantioselective interaction between surfaces and chiral molecules, template-induced synthesis and chirality transfer, and photon-induced chiral nanomaterials. However, as in many natural systems 54 , these transfer mechanisms cannot be analysed separately because a concomitance of effects is responsible for the resulting chiral morphologies, in particular for highly crystalline nanomaterials, for which template-induced and photon-induced syntheses cannot be entirely decoupled from enantioselective interactions at high Miller index surfaces. Finally, we present potential applications in photonics (for example, polarization-control, non-linear optics), sensing (enantiomer discrimination), catalysis (chemical and pharmaceutical) and biomedicine (for example, photothermal and photodynamic therapies). Chirality in biologyChirality exists across multiple size scales in biological entities, dictating their geometries, properties and behaviour. For example, aminoacyl-tRNA synthases, enzymes involved in the selection of amino acids in protein synthesis, preferentially bind to l-amino acids by steric exclusion of d-amino acids 55 . Peptide elongation of d-amino acids at the ribosomes is slow owing to the large distance between the reaction sites 56 , limiting the production of peptides with incorporated d-amino acids 57,58 . The incorporation of some d-amino acids, such as d-Asp and d-Ser, has been linked to amyloid-β peptides present in the brains of patients with Alzheimer disease 59 , indicating that chirality at the molecular level could extend its influence to the organism and its behaviour.Chirality also offers survival advantage(s) for organisms. Fan-like petal arrangements of mutated Arabidopsis thaliana show left-handed chirality and clockwise twisting. The handedness of their asymmetric g...

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“…The extraordinary chiral-optical (chiroptical) effects and chiralitydependent biological responses of chiral nanomaterials have facilitated their wide use in therapeutic applications. 94,95 Given the different recognition capabilities of nanomaterials and the different phagocytosis mechanisms and immunological responses of organisms toward chiral conformations, some chiral nanomaterials exert chirality-dependent effects that can be used in disease therapies. 96 It is worth mentioning that we have made great breakthroughs in cancer treatment, alleviating the progression of degenerative diseases and delaying the aging of the body.…”

Section: Chiral Nanomaterials For Disease Therapiesmentioning

confidence: 99%

Chiral nanomaterials for biosensing, bioimaging, and disease therapies

2022

Chem. Commun.

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Biological applications of chiral inorganic nanomaterials

Cited by 29 publications

References 127 publications

Coordination-Driven Self-Assembly of Complexes Constructed from Two Helical Ligands: Synthesis, Structures, and Selective Gas Adsorption Properties

Coordination-Driven Self-Assembly of Complexes Constructed from Two Helical Ligands: Synthesis, Structures, and Selective Gas Adsorption Properties

Bioinspired chiral inorganic nanomaterials

Chiral nanomaterials for biosensing, bioimaging, and disease therapies

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