Biological applications of copper-containing materials

Wang, Peng; Yuan, Yonghui; Xu, Ke; Zhong, Hongshan; Yang, Yinghui; Jin, Shiyu; Yang, Kè; Qi, Xun

doi:10.1016/j.bioactmat.2020.09.017

Cited by 123 publications

(52 citation statements)

References 139 publications

(89 reference statements)

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“…Copper absorption in mammals occurs predominantly in the small intestine, after digestion in the stomach and duodenum (Gaetke et al 2014 ; Nevitt et al 2012 ) and copper metabolism in human body is depicted in Fig. 1 b (Wang et al 2021 ). Excess copper content as well as its deficiency causes problems in animals (Iakovidis et al 2011 ).…”

Section: Effect Of Copper Content In Human Bodymentioning

confidence: 99%

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Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

et al. 2021

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Copper (Cu) and its alloys are prospective materials in fighting covid-19 virus and several microbial pandemics, due to its excellent antiviral as well as antimicrobial properties. Even though many studies have proved that copper and its alloys exhibit antiviral properties, this research arena requires further research attention. Several studies conducted on copper and its alloys have proven that copper-based alloys possess excellent potential in controlling the spread of infectious diseases. Moreover, recent studies indicate that these alloys can effectively inactivate the covid-19 virus. In view of this, the present article reviews the importance of copper and its alloys in reducing the spread and infection of covid-19, which is a global pandemic. The electronic databases such as ScienceDirect, Web of Science and PubMed were searched for identifying relevant studies in the present review article. The review starts with a brief description on the history of copper usage in medicine followed by the effect of copper content in human body and antiviral mechanisms of copper against covid-19. The subsequent sections describe the distinctive copper based material systems such as alloys, nanomaterials and coating technologies in combating the spread of covid-19. Overall, copper based materials can be propitiously used as part of preventive and therapeutic strategies in the fight against covid-19 virus.

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Section: Effect Of Copper Content In Human Bodymentioning

confidence: 99%

“…b Copper metabolism inside human body upon absorption by stomach and small intestine and the mechanism by which copper compounds being transferred to different parts of human body. Reprinted from (Wang et al 2021 ), with permission from Elsevier …”

Section: Effect Of Copper Content In Human Bodymentioning

confidence: 99%

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

et al. 2021

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“…Most Cu in the body is distributed in the bones and muscles, and that ingested from food is mainly excreted through the bile. Maintaining Cu homeostasis is important because both its deficiency and excess can cause many diseases (Wang et al, 2021). The minimum intake recommended by the US Institute of Medicine to prevent Cu deficiency in adults is 0.9 mg/day, with a tolerable upper limit of 10 mg/d (Trumbo et al, 2001).…”

Section: Cumentioning

confidence: 99%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

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Implants are widely used in orthopedic surgery and are gaining attention of late. However, their use is restricted by implant-associated infections (IAI), which represent one of the most serious and dangerous complications of implant surgeries. Various strategies have been developed to prevent and treat IAI, among which the closest to clinical translation is designing metal materials with antibacterial functions by alloying methods based on existing materials, including titanium, cobalt, tantalum, and biodegradable metals. This review first discusses the complex interaction between bacteria, host cells, and materials in IAI and the mechanisms underlying the antibacterial effects of biomedical metals and alloys. Then, their applications for the prevention and treatment of IAI are highlighted. Finally, new insights into their clinical translation are provided. This review also provides suggestions for further development of antibacterial metals and alloys.

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“…Furthermore, PI has higher affinity to bind DNA than SYTO 9. When bacterial cytoplasmic membrane is damaged and both stains are exposed to the same DNA, PI will replace SYTO 9 resulting in red fluorescent signal and a reduction in the SYTO 9 fluorescence [ 37 , 39 , 40 ]. As Fig.…”

Section: Resultsmentioning

confidence: 99%

Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity

Shi

Feng

Lin

et al. 2021

Bioactive Materials

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Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity. Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches, we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects. Herein, a surface-nanoengineered antimicrobial liposome (SNAL) is developed with the morphological features of enveloped viruses, including a moderate size range, lipid-based membrane structure, and highly lipopeptide-enriched bilayer surface. The SNAL possesses virus-like infection to bacterial cells, which can mediate high-efficiency and high-selectivity bacteria binding, rapidly attack and invade bacteria via plasma membrane fusion pathway, and induce a local “burst” release of lipopeptide to produce irreversible damage of cell membrane. Remarkably, viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations (1.6–6.3 μg mL −1 ), high bactericidal efficiency of >99% within 2 h, >10-fold enhanced selectivity over free lipopeptide, 99.8% reduction in skin MRSA load after a single treatment, and negligible toxicity. This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials.

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Biological applications of copper-containing materials

Cited by 123 publications

References 139 publications

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity

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