2011
DOI: 10.5114/aoms.2011.26611
|View full text |Cite
|
Sign up to set email alerts
|

Biological artificial valve dysfunction – single-centre, observational echocardiographic study in patients operated on before age 65 years

Abstract: IntroductionPatients with implanted bioprostheses are at risk of structural dysfunction which results from the limited durability of biological valves. The aim of this study was to analyse the mechanism of bioprosthesis degeneration and to evaluate the usability of transthoracic and transoesophageal echocardiography in determining the indications for reoperation in 117 patients with a bioprosthesis implanted before 65 years old.Material and methodsThe study comprised 117 consecutive patients (M – 27, F – 90, a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2014
2014
2021
2021

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 22 publications
0
3
0
Order By: Relevance
“…The most common mechanism of SVD of mitral bioprostheses is regurgitation as an effect of leaflet prolapse or perforation. Degeneration of aortic bioprostheses usually causes AS (39). Tissue calcification (passive or phospholipid-directed) of fixed biological tissue is believed to occur passively in the bloodstream by recruitment processes taking advantage of calcium binding to tissue-fixed negatively-charged phospholipids.…”
Section: Structural Valve Degenerationmentioning
confidence: 99%
See 2 more Smart Citations
“…The most common mechanism of SVD of mitral bioprostheses is regurgitation as an effect of leaflet prolapse or perforation. Degeneration of aortic bioprostheses usually causes AS (39). Tissue calcification (passive or phospholipid-directed) of fixed biological tissue is believed to occur passively in the bloodstream by recruitment processes taking advantage of calcium binding to tissue-fixed negatively-charged phospholipids.…”
Section: Structural Valve Degenerationmentioning
confidence: 99%
“…These results suggest that antibody-mediated inflammation may contribute to BHV calcification and that the antibody originates from a carbohydrate source as the tissue is heavily fixed with glutaraldehyde to eliminate the antigenicity proteins via cross-linking. Several studies have generated alpha-1,3-galactosyltransferase-1 (GT1) knockout (GT1KO) pigs by mutating pigs' alpha-1,3-galactosyltransferase-1 (GGTA-1) to abolish the enzyme function, where the synthesis of α-Gal moieties on glycoproteins is blocked when homozygous (3739). The tissue from GTKO pigs do not bind to anti-Gal antibody and no specific anti-Gal antibody response is elicited when GTKO cells, tissue, and organs are transplanted (3739).…”
Section: Immune Injurymentioning
confidence: 99%
See 1 more Smart Citation