Biological background of dermal substitutes

Veen, Vincent C. van der; Wal, Martijn B. A. van der; Leeuwen, Michiel C. E. van; Ulrich, Magda M. W.; Middelkoop, Esther

doi:10.1016/j.burns.2009.07.012

Cited by 217 publications

(172 citation statements)

References 167 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…They act as matrices or scaffolds and promote new tissue growth and enhance wound healing (1,2), with enhanced pliability and a more favourable scar. Dermal substitutes play a major role in repairing full thickness skin defects, both in acute and chronic wounds (3), and there is evidence that they improve scar quality (4).…”

Section: Definition Of Dermal Substitutesmentioning

confidence: 99%

“…It is important to have an effective dermal replacement because dermal tissue does not regenerate into normal dermis in vivo after full thickness dermal injuries. Application of a dermal substitute underneath the autologous skin graft may improve the wound healing process (8) in the treatment of burns, skin ulcers, various deep wounds, and unstable scar replacement (3,4,7). In addition, dermal substitutes play a role in control of scarring (2).…”

Section: History Of Dermal Substitutesmentioning

confidence: 99%

“…In a porcine full-thickness wound model, elastincoated collagen matrices reduced granulation tissue formation, fibrosis, and contraction, and stimulated collagen deposition by fibroblasts (3). Clinical trials with a long-term clinical evaluation showed no difference in scar elasticity between the described dermal substitute and split thickness grafts alone (49).…”

Section: Matriderm ®mentioning

confidence: 99%

“…It is more readily removed than allograft, with significantly higher level of patient satisfaction (3,56). There have been no reported adverse reactions to Dermagraft ® , with no evidence of rejection, early deterioration, or separation from wound [Hansbrough et al 1997].…”

Section: Synthetic Materials Dermagraft ®mentioning

confidence: 99%

See 3 more Smart Citations

The Use of Dermal Substitutes in Burn Surgery: Acute Phase

Arno¹,

Jeschke²

2013

Dermal Replacements in General, Burn, and Plastic Surgery

View full text Add to dashboard Cite

Dermal substitutes are increasingly becoming an essential part of the burn care strategy. During the acute phase of burn treatment, dermal substitutes improve functional and cosmetic results long-term and thus increase quality of life. In the chronic wound setting, dermal substitutes are used to reconstruct and improve burn scars and other defects. Despite some successes in the use of dermal substitutes there are more needs and requirements to further improve outcomes and hence further research is required not only to strengthen scientific evidence regarding their effects but also to develop new technology and products. Dermal substitutes also emerge as pivotal research strategies to develop adequate scaffolds for stem cells, tissue engineering and regenerative medicine applications to obtain long-lasting and scarless artificial skin. This review discusses status-quo of dermal substitutes and novel strategies in the use of dermal substitutes with a focus on burn care.

show abstract

Section: Definition Of Dermal Substitutesmentioning

confidence: 99%

Section: History Of Dermal Substitutesmentioning

confidence: 99%

Section: Matriderm ®mentioning

confidence: 99%

Section: Synthetic Materials Dermagraft ®mentioning

confidence: 99%

See 2 more Smart Citations

The Use of Dermal Substitutes in Burn Surgery: Acute Phase

Arno¹,

Jeschke²

2013

Dermal Replacements in General, Burn, and Plastic Surgery

View full text Add to dashboard Cite

show abstract

“…PHSRN (proline-histidine-serinearginine-glutamate), a cell binding peptide sequence has been found to act synergistically with RGD sequence for cell adhesion. (van der Veen, 2010;Davis, 2001) When applied individually it can stimulate invasion of ECM by keratinocytes and fibroblasts in vitro and it can enhance the re-epithelialization and concentration of dermal wounds in healingimpaired diabetic mice. (Livant, 2000) Other peptides sequences such as laminin-derived YIGSR (tyrosine-isoleucine-glycine-serine-arginine), LRE (leucine-arginine-glutamic acid) or www.intechopen.com IKVAV (isoleucine-lysine-valine-alanine-valine) have potential application in nerve regeneration.…”

Section: Bioactive Peptides and Peptide Amphiphiles For Regeneration mentioning

confidence: 99%