Biological basis for PCO<sub>2</sub> as a detector of ischemia

Ti, Tønnessen

doi:10.1111/j.1399-6576.1997.tb04764.x

Cited by 41 publications

(33 citation statements)

References 71 publications

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“…During aerobic conditions, the gradient between tissue and venous PCO 2 should not increase much despite reduced blood flow. However, the more ischemic the tissue the less reliable is a venous PCO 2 sample when it comes to reflecting tissue metabolism [19]. The gradient between subcutaneous and venous PCO 2 during hyperoxia and initial hypoxia in the present study was 1-2 mm Hg.…”

Section: Discussionmentioning

confidence: 66%

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Effect of Hyperoxia and Hypoxia on Subcutaneous Tissue Gases and pH

Mellström

Hartmann²,

Jedlinska³

et al. 1999

Eur Surg Res

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The effect of different fractions of inspired oxygen on subcutaneous oxygen tension, carbon dioxide tension and pH in relation to arterial and mixed venous blood gases and pH and hemodynamic variables was evaluated in 13 domestic pigs. Subcutaneous, arterial and mixed venous oxygen tensions were closely correlated (r = 0.94). A minor significant increase in subcutaneous carbon dioxide tension was noted during hyperoxia (p < 0.05). A major increase (33%) was noted during the last step of hypoxia, when arterial and mixed venous carbon dioxide tensions increased only 12 and 17%, respectively. A minor decrease in subcutaneous pH was noted during hyperoxia (p < 0.05) and a major decrease during hypoxia (p < 0.05). Measurements of subcutaneous tissue gases and pH are indicators of oxygen utilization during hyper- and hypoxia.

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Section: Discussionmentioning

confidence: 66%

“…However, CO 2 concentration beyond aerobic production is a consequence of protons formed during anaerobic conditions which to a large extent react with bicarbonate to form CO 2 and H 2 O. If blood supply is reduced during metabolic acidosis, CO 2 will accumulate in the tissue [19].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hyperoxia and Hypoxia on Subcutaneous Tissue Gases and pH

Mellström

Hartmann²,

Jedlinska³

et al. 1999

Eur Surg Res

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show abstract

“…The clinical interpretation of the increased CBFV during the postarrythmia period should therefore be made with some caution. However, the concentration of brain tissue pCO 2 presumably increased significantly during ischemia due to intracellular lactic acidosis being buffered by bicarbonate [8]. Furthermore, substantial amounts of adenosine triphosphate were most likely broken down to adenosine which is also a very potent vasodilator.…”

Section: Discussionmentioning

confidence: 99%

Ventricular Fibrillation during Off-Pump Coronary Artery Bypass Grafting: Transcranial Doppler and Clinical Findings

Lund

Lundblad²,

Fosse³

et al. 2001

Cerebrovasc Dis

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A 73-year-old male developed ventricular fibrillation which lasted for 2 min and 24 s, during off-pump coronary artery bypass grafting. Cerebral hemodynamics were assessed by continuous transcranial Doppler monitoring. Ventricular fibrillation resulted in an immediate fall in cerebral blood flow velocities to almost zero with only slight fluctuations. This was then followed by a pronounced reactive hyperperfusion. Cerebral magnetic resonance imaging examinations and detailed neurological and neuropsychological evaluations were performed before and at 3 and 12 months after surgery. No evidence of cerebral damage was found.

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“…Cortical pCO 2 values were calculated from tissue pH measurements, assuming constant ischemic tissue bicarbonate during complete renal circulatory arrest, corresponding to preischemic arterial values. This is a common assumption in acid-base splanchnic physiology, and, although certainly arguable, 8 it should be considered that more precise CO 2 determinations would be needless for the purpose of our study. CO 2 values found were expressed as partial pressures in SI units (kPa).…”

Section: In Vivo Studymentioning

confidence: 99%

“…7 CO 2 values increase as a result of bicarbonate buffering of anaerobic acid generation, coupled with CO 2 retention due to impaired perfusion. 7,8 Hypercapnia influences a number of cell features that have been closely linked to the apoptotic process, such as mitochondrial metabolism and intracellular pH. 9,10 However, until now, cell culture models of renal ischemia/reperfusion (I/R) injury have not considered the possible dependence of apoptosis on ischemic hypercapnia.…”

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confidence: 99%

Low O2 and high CO2 in LLC-PK1 cells culture mimics renal ischemia-induced apoptosis

Hotter

Palacios

Solà

2004

Laboratory Investigation

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Ischemia, absence or loss of blood flow in organs always presents as a dual phenomenon: tissue oxygen deficit and CO 2 excess (hypercapnia). Commonly hypoxic cell culture models kept CO 2 at normal nonischemic values. We report a study of apoptosis in an in vitro model of renal hypoxia that mimics in vivo tissue gas atmosphere composition determined during experimental ischemia in rat kidney (low O 2 plus high CO 2 ). Renal tubular LLC-PK1 cell were transiently exposed to hypoxia, to hypercapnia or to both conditions (simulated ischemia). Exposure to simulated ischemic atmosphere, but not to low O 2 or high CO 2 alone, induced cell apoptosis in vitro. This suggests that ischemia-induced apoptosis in vivo would be dependent on the natural, joint action of hypoxia and hypercapnia. This should be taken into account in cell culture studies that would like to mimic in vivo ischemic conditions.

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Biological basis for PCO₂ as a detector of ischemia

Cited by 41 publications

References 71 publications

Effect of Hyperoxia and Hypoxia on Subcutaneous Tissue Gases and pH

Effect of Hyperoxia and Hypoxia on Subcutaneous Tissue Gases and pH

Ventricular Fibrillation during Off-Pump Coronary Artery Bypass Grafting: Transcranial Doppler and Clinical Findings

Low O2 and high CO2 in LLC-PK1 cells culture mimics renal ischemia-induced apoptosis

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Biological basis for PCO2 as a detector of ischemia

Cited by 41 publications

References 71 publications

Effect of Hyperoxia and Hypoxia on Subcutaneous Tissue Gases and pH

Effect of Hyperoxia and Hypoxia on Subcutaneous Tissue Gases and pH

Ventricular Fibrillation during Off-Pump Coronary Artery Bypass Grafting: Transcranial Doppler and Clinical Findings

Low O2 and high CO2 in LLC-PK1 cells culture mimics renal ischemia-induced apoptosis

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Biological basis for PCO₂ as a detector of ischemia