Biological, behavioral, and socioeconomic factors associated with death from AIDS in Brasília, Brazil, in 2007

Abstract

Introduction:In the jurisdiction of Brasília, Brazil, significant reductions in mortality rates and lethality resulting from acquired immunodeficiency syndrome (AIDS) were observed shortly after the introduction of highly active antiretroviral therapy. In recent years, however, the decline of these rates has not been as significant. Non-adherence to treatment and delayed diagnosis appear to be the main factors that increase the risk of death from AIDS. Behavioral, socioeconomic, and biological factors could also be associated with increased risk of death due to AIDS. This study aimed to identify which of these factors were associated with deaths from AIDS in Brasília. Methods: A case-control study was undertaken using the data recorded in the Information System of Notifiable Diseases. Cases consisted of AIDS deaths occurring in 2007, residing in Brasília, and over 12 years of age. Controls consisted of AIDS patients who did not die until December 31 2007, also residing in Brasília, and over 12 years of age. For each group, frequency and proportion tables for the variables were prepared. The statistical association of each factor in isolation with the occurrence of the deaths was verified through a model of multivariate analysis using logistic regression. Results: The factors that were associated with an increased risk of death were intravenous drug use, age 50 years or more, and residing in a region whose residents have low per capita income. Conclusions: We identified factors associated with death due to AIDS that can guide health planning.

Impact of public health strategies on reducing AIDS mortality in southern Brazil

“…In contrast to the findings of Lopes et al., 9 we observed a significantly higher number of deaths among men, compared to the number among women. The proportion of death by sex in PLWH in Curitiba (2.6, 2.1, and 2.3 for 2000, 2006, and 2010, respectively) was similar to, although slightly higher than, the ratio for the general Brazilian population (1.9).…”

“…In this context, women are more likely to seek medical care and to have better treatment adherence, which may have affected our findings. 9 Furthermore, men typically exhibit a greater time of infection, compared to women. In the present study, we did not observe any significant sex-related differences in mortality, and the mortality rate remained approximately 2–3-fold higher for men, which is similar to the previously reported findings.…”

“…In 2009, 17 antiretroviral drugs were available through the Brazilian Public Health Service. 5,[7][8][9] The introduction of ART has led to a dramatic reduction in the mortality rate among patients with AIDS-defining conditions. However, there have been no corresponding changes for non-AIDS-defining conditions, which have subsequently become important causes of death.…”

HIV and Substance Use in Latin America: A Scoping Review

“…Higher mortality rates among PLWH in Brazil [ 141 , 142 , 143 , 144 , 145 , 146 , 147 ] and Mexico [ 44 ] have been associated with SU. Brazilian PLWH using drugs had a relative mortality risk of 3.1 compared to non-SU [ 143 ].…”

Factores asociados a la supervivencia, falla inmunológica y virológica en pacientes con VIH en targa en un hospital nacional de referencia durante el periodo 2010 – 2015

“…Aunque este hallazgo es compatible con un estudio realizado en China (25), la mayoría de estudios no encontraron asociación (10,31).…”