Biological benefits of an oleic acid–rich lipid emulsion for parenteral nutrition

Pontes-Arruda, Alessandro

doi:10.1016/j.clnu.2009.04.006

Cited by 18 publications

(14 citation statements)

References 47 publications

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“…Several studies have reported that olive oil-based ILE better maintains its physicochemical stability compared with other currently available ILEs [ 111 , 113 ]. Compared with three soybean oil-based ILEs, olive oil-based ILE had the smallest globule size distribution, with the least variation in size between globules [ 2 ]. Another study showed that the physicochemical stability deteriorated substantially over time for soybean and soybean/safflower oils compared with MCT/LCT and olive oil-based ILEs [ 111 ].…”

Section: Stabilitymentioning

confidence: 99%

“…The primary fatty acid in olive oil-based ILE is the omega (n)-9 monounsaturated fatty acid (MUFA), oleic acid. MUFAs have been associated with health benefits [ 2 , 3 ], and diets rich in MUFAs have been associated with a lower risk of inflammatory disease [ 4 ]. Oleic acid contributes approximately 60% of the total fatty acids in the 80% olive oil-based ILE [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Cai¹,

Calder

Cury-Boaventura

et al. 2018

Nutrients

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Intravenous lipid emulsions (ILEs) have been an integral component of parenteral nutrition for more than 50 years. Numerous formulations are available and are based on vegetable (soybean, olive, coconut) and animal (fish) oils. Therefore, each of these formulations has a unique fatty acid composition that offers both benefits and limitations. As clinical experience and our understanding of the effects of fatty acids on various physiological processes has grown, there is evidence to suggest that some ILEs may have benefits compared with others. Current evidence suggests that olive oil-based ILE may preserve immune, hepatobiliary, and endothelial cell function, and may reduce lipid peroxidation and plasma lipid levels. There is good evidence from a large randomized controlled study to support a benefit of olive oil-based ILE over soybean oil-based ILE on reducing infections in critically ill patients. At present there is limited evidence to demonstrate a benefit of olive oil-based ILE over other ILEs on glucose metabolism, and few data exist to demonstrate a benefit on clinical outcomes such as hospital or intensive care unit stay, duration of mechanical ventilation, or mortality. We review the current research and clinical evidence supporting the potential positive biological and clinical aspects of olive oil-based ILE and conclude that olive oil-based ILE is well tolerated and provides effective nutritional support to various PN-requiring patient populations. Olive oil-based ILE appears to support the innate immune system, is associated with fewer infections, induces less lipid peroxidation, and is not associated with increased hepatobiliary or lipid disturbances. These data would suggest that olive oil-based ILE is a valuable option in various PN-requiring patient populations.

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Section: Stabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Cai¹,

Calder

Cury-Boaventura

et al. 2018

Nutrients

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“…In addition, it is being used for parenteral formulations clinically. 19 Therefore, OA was selected in this study to ion-pair with LBT. Due to LBT's instability, it decomposes easily in a strong alkaline environment.…”

Section: Preparation Of Lbt-oamentioning

confidence: 99%

Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

Zhao¹,

Lü²,

Gong³

et al. 2013

IJN

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Background: Intravenous injection of lycobetaine was found to show significant cytotoxic activity against (inter alia) Lewis lung carcinoma, but its therapeutic use is largely limited due to an extremely short half-life in blood. This study aimed at developing a novel lipid nanocarrierbased formulation for lycobetaine delivery. The formulation is feasible for scale-up production, exhibiting good parenteral acceptability and improved circulation characteristics. Methods: To enhance its lipophilicity, oleic acid was selected to form ionic complexes with lycobetaine (LBT). The nanoemulsion loaded with LBT-oleic acid complex (LBT-OA-nanoemulsion) and PEGylated LBT-OA-nanoemulsion (NE) (LBT-OA-PEG-NE) were prepared by a simple high-pressure homogenization method. Results: A high-encapsulation efficiency of around 97.32% ± 2.09% was obtained for LBT-OA-PEG-NE under optimized conditions. Furthermore, the in vivo pharmacokinetics and biodistribution of LBT-OA-NE, LBT-OA-PEG-NE, and free LBT were studied in rats. Free LBT and LBT-OA-PEG-NE displayed AUC 0-10h (area under the concentration-time curve from 0 to 10 hours) of 112.99 mg/L*minute and 3452.09 mg/L*minute via intravenous administration (P , 0.005), respectively. Moreover, LBT-OA-PEG-NE showed significantly lower LBT concentration in the heart, liver, and kidney, while achieving higher concentration of LBT in the lung when compared to free LBT at the same time (P , 0.005). The LBT-OA-PEG-NE exhibited higher growth inhibitory effect and longer survival time than free LBT in both heterotopic and lung metastatic tumor models. Conclusion: These results demonstrated that LBT-OA-PEG-NE is an attractive parenteral formulation for cancer therapy.

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“…Most importantly, OA is available for clinical parenteral usage. 35 In this study, a negatively charged carboxyl group of OA ( Figure 1C) attached with the protonized tertiary nitrogen of VCR to form an ion-pair complex, and its long carbon chain could offer the VCR more hydrophobicity.…”

Section: Preparation Of Vcr-oa Ion-pair Complexmentioning

confidence: 74%

A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies

Zhang¹,

Zheng²,

Peng³

et al. 2013

IJN

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Background: Vincristine (VCR), which is a widely used antineoplastic drug, was integrated with a submicron-emulsion drug-delivery system to enhance the anticancer effect. Methods: After the formation of a VCR-oleic acid ion-pair complex (VCR-OA), the VCR-OAloaded submicron emulsion (VCR-OA-SME), prepared by classical high-pressure homogenization, was characterized and its in vitro anticancer effects were evaluated. Results: The submicron-emulsion formulation exhibited a homogeneous round shape. The mean particle size, zeta potential, and encapsulation efficiency were 157.6 ± 12.6 nm, −26.5 ± 5.0 mV and 78.64% ± 3.44%, respectively. An in vitro release study of the VCR-OA-SME revealed that 12.4% of the VCR was released within the first 2 hours (initial burst-release phase) and the rest of the drug was detected in the subsequent sustained-release phase. Compared with VCR solution, the pharmacokinetic study of VCR-OA-SME showed relatively longer mean residence time (mean residence time [0-∞] increased from 187.19 to 227.56 minutes), higher maximum concentration (from 252.13 ng/mL to 533.34 ng/mL), and greater area under the curve (area under the curve [0-∞] from 11,417.77 µg/L/minute to 17,164.34 µg/L/minute. Moreover, the VCR-OA-SME exhibited higher cytotoxicity (P , 0.05) on tumor cells by inducing cell arrest in the G 2 /M phase or even apoptosis (P , 0.05). Conclusion:The VCR-OA-SME formulation in our study displayed great potential for an anticancer effect for VCR.

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Biological benefits of an oleic acid–rich lipid emulsion for parenteral nutrition

Cited by 18 publications

References 47 publications

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies

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Biological benefits of an oleic acid–rich lipid emulsion for parenteral nutrition

Cited by 18 publications

References 47 publications

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Nanoemulsion loaded with lycobetaine&ndash;oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

A novel submicron emulsion system loaded with vincristine&ndash;oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies

Contact Info

Product

Resources

About

Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity

A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies