Biological, biochemical, and molecular parameters of Helisoma duryi snails exposed to the pesticides Malathion and Deltamethrin

Bakry, Fayez A.; Hasheesh, Wafaa S.; Hamdi, Salwa

doi:10.1016/j.pestbp.2011.08.004

Cited by 25 publications

(17 citation statements)

References 34 publications

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“…These differences indicated that the tested pesticides caused intensive molluscicidal effects that induced fractionation of the native protein. This report was previously recorded by Bakry et al (2011) who found that deltamethrin and malathion had qualitative and quantitative effect on the protein patterns of Helisoma duryi snails. Furthermore, treated groups with the present pesticides showed less number of protein bands indicating that the pesticides were thought to induce damage for these snails.…”

Section: Discussionsupporting

confidence: 64%

“…Pesticides are ubiquitous contaminants of the environment and have been found in samples from air, soil, water, and human and animal tissues all over the world. These cover a wide range of compounds used in pest control, such as fungicides, herbicides, molluscicides, insecticides, rodenticides and others (Bakry et al, 2011;Nasri et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides diazinon and profenofos

Bakry¹

2013

Afr. J. Pharm. Pharmacol.

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The use of pesticides is widespread in agricultural activities. These pesticides may contaminate the irrigation and drainage systems during agricultural activities and pests' control and then negatively affect the biotic and abiotic component of the polluted water courses. The present study aimed to evaluate the effect of the pesticides diazinon and profenofos on some biological activities of Biomphalaria alexandrina snails such as fatty acid profile, some antioxidant enzymes like thioredoxin reductase (TrxR), sorbitol dehydrogenase (SDH), superoxide dismutase (SOD), catalase (CAT) as well as glutathione reductase (GR) and lipid peroxidation (LP) and protein patterns in snails' tissues exposed for 4 weeks to LC 10 of diazinon and profenofos. The results showed that the two pesticides caused considerable reduction in survival rates and egg production of treated snails. Identification of fatty acids composition in snails' tissues treated with diazinon and profenofos pesticides was carried out using gas liquid chromatography (GLC). The results declared alteration in fatty acid profile, fluctuation in percent of long chain and short chain fatty acid contributions either saturated or unsaturated ones and a decrease in total lipid content in tissues of snails treated with these pesticides. The data demonstrate that, there was a significant inhibition in the activities of tissues SOD, CAT, GR, TrxR and SDH in tissues of treated snails while a significant elevation was detected in lipid peroxidation as compared to the normal control. On the other hand, the electrophoretic pattern of total protein showed differences in number and molecular weights of protein bands due to snails' treatment. It was concluded that the residues of diazinon and profenofos pesticides in aquatic environments have toxic effects on B. alexandrina snails.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides diazinon and profenofos

Bakry¹

2013

Afr. J. Pharm. Pharmacol.

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“…Larvae show substantially increased fructose (5.7-fold at 12 hours), indicating stimulation of glycolysis by permethrin. Decreased lactate in both the larvae and adult is consistent with the inhibition of lactate dehydrogenase which also occurs in snails exposed to pyrethroids (Bakry et al, 2011).…”

Section: Energy Metabolismsupporting

confidence: 68%

“…In larvae there is an accumulation of ornithine and urea (Table S3) potentially due to inhibition of ornithine aminotransferase which is a known secondary target of pyrethroids (Bakry et al, 2011). Free amino acids produce ammonia under physiological conditions by deamination (Stadtman, 1993) which has to be detoxified by the urea cycle.…”

Section: Nitrogen Metabolismmentioning

confidence: 99%

Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival

Brinzer

Henderson

Marchiondo

et al. 2015

Insect Biochemistry and Molecular Biology

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Insecticides and associated synergists are rapidly losing efficacy in target insect pest populations making the discovery of alternatives a priority. To discover novel targets for permethrin synergists, metabolomics was performed on permethrin-treated Drosophila melanogaster. Changes were observed in several metabolic pathways including those for amino acids, glycogen, glycolysis, energy, nitrogen, NAD + , purine, pyrimidine, lipids and carnitine.Markers for acidosis, ammonia stress, oxidative stress and detoxification responses were also observed. Many of these changes had not been previously characterized after permethrin exposure. From the altered pathways, tryptophan catabolism was selected for further investigation. The knockdown of some tryptophan catabolism genes (vermilion, cinnabar and CG6950) in the whole fly and in specific tissues including fat body, midgut and Malpighian tubules using targeted RNAi resulted in altered survival phenotypes against acute topical permethrin exposure. The knockdown of vermilion, cinnabar and CG6950 in the whole fly also altered survival phenotypes against chronic oral permethrin, fenvalerate, DDT, chlorpyriphos and hydramethylnon exposure. Thus tryptophan catabolism has a previously uncharacterized role in defence against insecticides, and shows that metabolomics is a powerful tool for target identification in pesticide research.

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“…The persistence in the environment of some pesticides may contaminate any of the terrestrial or aquatic species (Russo and Lagadic, 2004;Bakry et al, 2011). The improper use of chemicals to kill fish is a common practice in the present day world especially in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Sublethal Concentrations of Glyphosate and Paraquat Herbicide in the African Catfish Clarias gariepinus

Ayanda¹

2018

IJAB

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Biological, biochemical, and molecular parameters of Helisoma duryi snails exposed to the pesticides Malathion and Deltamethrin

Cited by 25 publications

References 34 publications

Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides diazinon and profenofos

Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides diazinon and profenofos

Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival

Toxicity of Sublethal Concentrations of Glyphosate and Paraquat Herbicide in the African Catfish Clarias gariepinus

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