Biological causes of prosthetic joint failure

Revell, Peter A.

doi:10.1016/b978-0-12-821082-6.00018-2

Cited by 2 publications

(2 citation statements)

References 304 publications

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“…The biomaterials surface‐to‐volume ratio is found to influence the composition of the FBR. Larger surface‐to‐volume ratios (e.g., fabrics and microspheres) have larger numbers of macrophages and Langhans giant cells 62 . The process of repair at implant site depends on the capacity of the existent cells and the persistence of the ECM framework 53 .…”

Section: Bioadhesives Host Responsesmentioning

confidence: 99%

“…Larger surface-to-volume ratios (e.g., fabrics and microspheres) have larger numbers of macrophages and Langhans giant cells. 62 The process of repair at implant site depends on the capacity of the existent cells and the persistence of the ECM framework. 53 Myofibroblasts and fibrocytes play an important role in the formation of collagenous fibers, a principal component of the fibrous capsule.…”

Section: Good Adhesion Strengthmentioning

confidence: 99%

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Composition, host responses and clinical applications of bioadhesives

et al. 2022

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Bioadhesives are medical devices used to join or seal tissues that have been injured or incised. They have been classified into tissue adhesives, sealants, and hemostatic agents. Bioadhesives such as FloSeal ® , CoSeal ® , BioGlue ® , Evicel ® , Tisseel ® , Progel™ PALS, and TissuGlu ® have been commercialized and used in clinical setting. They can be formulated with natural or synthetic components or a combination of both including albumin, glutaraldehyde, chitosan, cyanoacrylate, fibrin and thrombin, gelatin, polyethylene glycol (PEG), along with urethanes. Each formulation has intrinsic properties and has been developed and validated for a specific application. This review article briefs the mechanisms by which bioadhesives forms adhesion to tissues and highlights the correlation between bioadhesives composition and their potential host responses. Furthermore, clinical applications of bioadhesives and their applicationdriven requirements are outlined.

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Section: Bioadhesives Host Responsesmentioning

confidence: 99%

Section: Good Adhesion Strengthmentioning

confidence: 99%

Composition, host responses and clinical applications of bioadhesives

et al. 2022

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Analysis of the Multiwalled Carbon Nanotubes Reinforced Polymethyl Methacrylate Bone Cement’s Characteristics and In Vitro Bioactivity to Prolong Its Functionality in Orthopedic Application

Kumar

Shanmugapriya

Arun

et al. 2023

Advances in Polymer Technology

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Polymethyl methacrylate (PMMA) bone cement is being used to fill voids that are created due to vertebral compression fractures. It is also a grouting medium in orthopedic joint replacement surgeries as they possess fast primary fixation to the bone. Considering the cement properties and in vitro bioactivity of bone cement is essential for cemented hip and knee joint replacement surgeries. In this study, commercial Simplex P bone cement (SPBC) is modified with carboxyl- (-COOH-) functionalized multiwalled carbon nanotubes (MWCNTs) to overcome high polymerization temperature, volumetric shrinkage, surface wettability, and in vitro bioactivity. A geometric dilution method is used to incorporate MWCNTs with the PMMA powder, which is in unequal proportions. The PMMA/MWCNT nanocomposite with different concentrations of reinforcements, such as 0.1, 0.3, 0.5, and 0.7 weight percentages, is prepared for the investigation. It was observed that the MWCNTs had a beneficial impact on PMMA bone cement (PMMA-BC) by enhancing its setting time (2.94%↑) and surface wettability (23.58%↑). Also, diminished polymerization temperature (29%↓) and volumetric shrinkage (40.9%↓) are observed for an optimum concentration of 0.7 wt. %. The bioactivity of the cement surface is validated by the in vitro bioactivity observed in simulated body fluid (SBF) through the development of primary and secondary apatite. It is concluded that the synthesized PMMA/MWCNT nanocomposites are found to have enhanced cement properties compared to PMMA-BC.

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Biological causes of prosthetic joint failure

Cited by 2 publications

References 304 publications

Composition, host responses and clinical applications of bioadhesives

Composition, host responses and clinical applications of bioadhesives

Analysis of the Multiwalled Carbon Nanotubes Reinforced Polymethyl Methacrylate Bone Cement’s Characteristics and In Vitro Bioactivity to Prolong Its Functionality in Orthopedic Application

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