Biological characteristics and virulence of Helicobacter pylori

Исаева, Г. Ш.; Валиева, Р И

doi:10.36488/cmac.2018.1.14-23

Cited by 13 publications

(6 citation statements)

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“…The formation of a peptic defect is not only the result of local damage to the DMM against an imbalance of aggression and the protection of HP microbial contamination, but also a consequence of a breakdown in adaptation, an imbalance in the immune system. DU in most patients is associated with intestinal dysbiosis, microbial antigens of which can cause sensitization and exacerbate the immune deficiency in DUD patients [1,2]. Healing of the peptic defect was achieved in a shorter time with successful eradication of HP (in the 1st group -for 24.8 ± ± 1.2 days with an eradication efficiency of 59%; in the 2 nd group -for 17.3 ± 0.46 days with an effectiveness eradication 86%).…”

Section: Materials and Methods 52 Patients With Dumentioning

confidence: 99%

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Disorders of Immune Reactions and Their Immunorehabilitation in Patients with Duodenal Ulcer

Suleyman Fayzullayevich

2023

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The immunoreactivity was analyzed in 52 patients with duodenal ulcer (DU) and 36 healthy persons. The suppression of T-system and its subsets, a tension of humoral link of immunity was observed in patient.The use traditional method of treatmend was not made a result to disorder of second immunodificiens in patients with DU.The usage of Thymoptinum, the dose of which was 1.0 mg -1.2 mg (in one course) at second group patients (n = 24) with DU cured immune disorder, increased cell immunity, and had immunocorrесtion and eradication features.

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Section: Materials and Methods 52 Patients With Dumentioning

confidence: 99%

“…According to world statistics its prevalence among the adult population of all countries reaches from 7 to 10%. The etiology of DU associated with Helicobacter pylori (HP infection) is associated with contamination of the mucous membrane (MM) of the gastroduodenal zone -GDZ (gastric MM -GMM and DMM) with these cytotoxic strains of these bacteria [1][2][3][4].…”

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Disorders of Immune Reactions and Their Immunorehabilitation in Patients with Duodenal Ulcer

Suleyman Fayzullayevich

2023

ELBLS

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“…К наиболее известным адгезинам относят babA (Lewis blood group antigen-binding adhesion) и sabA (sialic Lewis Xantigen-binding adhesion). Эти адгезины распознают специфические углеводные фрагменты желудочного эпителия, что способствует инфекции и воспалительным процессам в желудочно-кишечном тракте [6]. Адгезия H. pylori к эпителиальным клеткам способствует прогрессированию воспаления в слизистой желудка, продукции аутоантител и разрушению париетальных клеток.…”

Section: Introductionunclassified

Helicobacter pylori genotypes in patients with stable angina combined with chronic gastritis

Приходько

Симонова

2021

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Research objective. То study the genotypes of Helicobacter pylori and their antibiotic sensitivity in patients with stable angina in combination with chronic gastritis. Material and methods. 46 patients with stable angina with a combination of chronic H. pylori-associated gastritis were included in the open prospective clinical study. To diagnose H. pylori, serological method of detection of antibodies in blood serum was used, PCR - diagnosis of H. pylori genes. Antibiotic sensitivity of H. pylori strains was studied by serial dilution method. Results. In the patients (n = 46) stable angina in combination with chronic gastritis in the endoscopic study by the EGDS method, gastrobioptates were obtained and further investigated. Chronic neatrophic gastritis was diagnosed in 54.3% of patients, atrophic gastritis - in 45.7%. It was found that the genotypes of H. pylori VacA had 8.7% of patients, CagA - 34.7%, HopQ - 13.1%, Oip - 30.4% of patients. Only 13.1% of patients had non-toxic genotypes. The absence of antibiotic resistance of the first line of erication therapy - clarithromycin and amoxicillin - was revealed. 45.7% of patients showed resistance, 39.1% showed weak sensitivity of H. pylori isolates to metronidazole. Conclusions. In patients with stable angina with a combination of chronic gastritis, H. pylori strains with toxigenic genotypes: CagA, Oip, Vac A, HopQ predominate. Resistance of H. pylori isolates to metronidazole was determined in 45.7% of patients.

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“…However, there was no such dependence on the inhabitants of East Asia [40]. Most authors argue that there is a close correlation [9,10,11,14,24,26], others believe that CagA-positive / negative strains of H.pylori are not related to the development of severe gastroduodenal pathology and do not find any significant differences in the activity of inflammation and colonization in different types of H. pylori infection [4,13,19].…”

Section: Introductionmentioning

confidence: 99%

The role of the CagA gene in the occurrence of the inflammatory response of the gastric mucosa in patients with chronic Helicobacter pylori-associated gastritis

Vernigorodskiy

Sukhan

2018

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Currently, Helicobacter pylori infection (H. pylori) is recognized as one of the most important risk factors for gastrocarcinogenesis. It is known that this infection does not directly cause neoplastic changes in the gastric mucosa, and this is due to a number of consecutive events due to the long persistence of the pathogen in the human body. The initial stage of this cascade, of course, is the inflammatory response, due to the body’s ability to adapt to extraneous infection, which is the inevitable result of the interaction of H. pylori with cells of the gastric epithelium. This direct damaging effect is enhanced by the production of vacuolating cytotoxin and the release of products of the cytotoxin-associated CagA gene, which, at a pathomorphological level, is manifested by inflammatory infiltration of the gastric mucosa (GM) to some extent. On the relationship between the degree of contamination and the activity of the inflammation of the GM in people infected with the CagA strain, today there are different, often conflicting opinions, which is why in this work we set the goal of establishing the relationship between the nature of the inflammatory response and the presence of the CagA gene in H. pylori- infected patients. The purpose of the study is to determinate the relationship between the nature of the inflammatory response and the genetic features of the H. pylori strain (CagA genotype).We examined 365 patients, among whom 40 people were included in the control group (18 women and 22 men, whose average age was 45,33±15,46 and 42,82±12,31, respectively) without any gastroenterological pathology in the anamnesis , patients with chronic non-atrophic gastritis (188 people) and chronic atrophic gastritis (137 people). A close relationship was established between the presence of the CagA gene, activity and the degree of contamination for chronic non-atrophic gastritis: for a low degree of contamination, Fisher’s exact test was = 0.002, p<0.05, for a moderate degree - 0.012, p<0.05, for a high degree - 0,012, p<0.05. Accordingly, in chronic atrophic gastritis: for a low degree of contamination Fisher’s exact test = 0.011, p<0.05, for a moderate degree - 0.003, p<0.05, for a high degree - 0.001, p<0.05. There is also a close relationship between the degree of contamination and the activity of chronic gastritis: in patients with a high degree of contamination, CG activity was determined, as a rule, for stage 2-3. In our study, the inflammatory response depended on the presence or absence of the H. pylori strain in the patient, which contains the CagA genotype, which, in our opinion, plays a key role in triggering a cascade of inflammatory changes in the GM and progression of chronic gastritis.

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Biological characteristics and virulence of Helicobacter pylori

Cited by 13 publications

References 103 publications

Disorders of Immune Reactions and Their Immunorehabilitation in Patients with Duodenal Ulcer

Disorders of Immune Reactions and Their Immunorehabilitation in Patients with Duodenal Ulcer

Helicobacter pylori genotypes in patients with stable angina combined with chronic gastritis

The role of the CagA gene in the occurrence of the inflammatory response of the gastric mucosa in patients with chronic Helicobacter pylori-associated gastritis

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